Recent progress in nanomaterial-based sensing of airborne viral and bacterial pathogens

Bhardwaj, Sanjeev K.; Bhardwaj, Neha; Kumar, Vanish; Bhatt, Deepanshu; Azzouz, Abdelmonaim; Bhaumik, Jayeeta; Kim, Ki‐Hyun; Deep, Akash

doi:10.1016/j.envint.2020.106183

Cited by 50 publications

(26 citation statements)

References 124 publications

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“…The signal generated from analytes in fluorescence detection is read using a microscope, camera, laser, or charged-coupled device. On the other hand, colorimetric methods have an advantage that the signal can be read by the naked eye without the necessity of requiring bulky instruments [ 82 ]. In recent years, alternative readout formats such as distance, text, and time have been used with PADs [ 83 ].…”

Section: Detection and Signal Read-out Methodsmentioning

confidence: 99%

Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

Özer

Henry

2021

TrAC Trends in Analytical Chemistry

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The importance of user-friendly, inexpensive, sensitive, and selective detection of viruses has been highlighted again due to the recent Coronavirus disease 2019 (COVID-19) pandemic. Among the analytical tools, paper-based devices (PADs) have become a leading alternative for point-of-care (POC) testing. In this review, we discuss the recent development strategies and applications in nucleic acid-based, antibody/antigen-based and other affinity-based PADs using optical and electrochemical detection methods for sensing viruses. In addition, advantages and drawbacks of presented PADs are identified. Current state and insights towards future perspectives are presented regarding developing POC diagnosis platform for COVID-19. This review considers state-of-the-art technologies for further development and improvement in PADs performance for virus detection.

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Section: Detection and Signal Read-out Methodsmentioning

confidence: 99%

Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

Özer

Henry

2021

TrAC Trends in Analytical Chemistry

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“…Then, the cDNA is amplified using conventional PCR. This process is complicated and time consuming for RNA viruses because it requires the additional step of cDNA template synthesis using RT-PCR ( Bhardwaj et al, 2021 ). The qPCR is similar to conventional (qualitative) PCR but requires a nonspecific dye, such as SYBR® green dye, for real-time quantification of the dsDNA PCR product ( Gupta, 2019 ).…”

Section: Virus Measurementsmentioning

confidence: 99%

“…Especially, paper-based analytical devices such as VFA ( Bhardwaj et al, 2020 ) and LFA ( Lee et al, 2020 ) integrated with air samplers can be used as an inexpensive portable platform for monitoring airborne viruses because of their low cost, porous structure, high surface-to-volume ratios, portability, and capillary action. Nanomaterials such as carbon nanotubes and graphene are highly desirable to be incorporated in these sensors for enhancing the sensitivity of biosensors, and stable and reproducible film deposition would be critical for long-term monitoring systems ( Bhardwaj et al, 2021 ). These nanomaterials demonstrate high surface-to-volume ratios and high electron transfer characteristics, which may be ideal for electrical and electrochemical biosensors.…”

Section: Conclusion and Future Prospectmentioning

confidence: 99%

Recent advancements in the measurement of pathogenic airborne viruses

Bhardwaj

Hong

Jang

et al. 2021

Journal of Hazardous Materials

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Air-transmissible pathogenic viruses, such as influenza viruses and coronaviruses, are some of the most fatal strains and spread rapidly by air, necessitating quick and stable measurements from sample air volumes to prevent further spread of diseases and to take appropriate steps rapidly. Measurements of airborne viruses generally require their collection into liquids or onto solid surfaces, with subsequent hydrosolization and then analysis using the growth method, nucleic-acid-based techniques, or immunoassays. Measurements can also be performed in real time without sampling, where species-specific determination is generally disabled. In this review, we introduce some recent advancements in the measurement of pathogenic airborne viruses. Air sampling and measurement technologies for viral aerosols are reviewed, with special focus on the effects of air sampling on damage to the sampled viruses and their measurements. Measurement of pathogenic airborne viruses is an interdisciplinary research area that requires understanding of both aerosol technology and biotechnology to effectively address the issues. Hence, this review is expected to provide some useful guidelines regarding appropriate air sampling and virus detection methods for particular applications.

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“…This makes nanomaterial-based sensors a better candidate for rapid and dependable detection of viral particles [26] . Many nanomaterials with transducing functions have been studied in recent decades, and several matrices for different sensors have been developed [42] . Nanomaterials like graphene, quantum dots, gold and silver nanoparticles have been explored to create sensors to detect viral particles.…”

Section: Types Of Sensors For Respiratory Viral Detectionmentioning

confidence: 99%

Nanomaterials-Based Sensors for Respiratory Viral Detection: A Review

et al. 2021

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Contagious diseases are the principal cause of mortality, particularly respiratory viruses, a real menace for public health and economic development worldwide. Therefore, timely diagnosis and treatments are the only lifesaving strategy to overcome any epidemic and particularly the ongoing prevailing pandemic COVID-19 caused by SARS-CoV-2. A rapid identification, point of care, portable, highly sensitive, stable, and inexpensive device is the needed which is exceptionally satisfied by sensors. Consequently, the researchers have directed their attention to employing sensors targeting multiple analyses of pathogenic detections across the world. Nanostructured materials (nanoparticles, nanowires, nanobundles, etc.), owing to their unique characteristics such as large surface-to-volume ratio and nanoscale interactions, are widely employed to fabricate facile sensors to meet all the immediate emerging challenges and threats. This review is anticipated to foster researchers in developing advanced nanomaterials-based sensors for the increasing number of COVID-19 cases across the globe. The mechanism of respiratory viral detection by nanomaterials-based sensors has been reported. Moreover, the advantages, disadvantages, and their comparison with conventional sensors are summarized. Furthermore, we have highlighted the challenges and future potential of these sensors for achieving efficient and rapid detection.

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Recent progress in nanomaterial-based sensing of airborne viral and bacterial pathogens

Cited by 50 publications

References 124 publications

Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

Recent advancements in the measurement of pathogenic airborne viruses

Nanomaterials-Based Sensors for Respiratory Viral Detection: A Review

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