Recent progress in nanomedicine-mediated cytosolic delivery

Son, Hangyu; Shin, Jeongsu; Park, Joonhyuck

doi:10.1039/d2ra07111h

Cited by 15 publications

(5 citation statements)

References 71 publications

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“…The ability of the DT3-CDs (or other CDs) to be cytosolic could make them useful for drug delivery, especially since many delivery systems have limited access to the cytosol where the drugs are needed for their mechanism of action. 46,47…”

Section: Discussionmentioning

confidence: 99%

Shining a light on cells: amine-passivated fluorescent carbon dots as bioimaging nanoprobes

Clermont-Paquette,

Larocque,

Piekny

et al. 2024

Mater. Adv.

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Section: Discussionmentioning

confidence: 99%

Shining a light on cells: amine-passivated fluorescent carbon dots as bioimaging nanoprobes

Clermont-Paquette,

Larocque,

Piekny

et al. 2024

Mater. Adv.

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“…In addition, how to control the precision of the required stimulus is also a problem that needs to be solved. Except for endosomal escape and stimulus-sensitive delivery, cytosolic delivery strategies of drugs also include penetrating peptides and fusogenic liposomes ( Son et al, 2023 ) ( Figure 4 ), such as penetrating peptides modified on nano-delivery vectors, which can be delivered into cytoplasm in a variety of ways. These cytosolic delivery strategies have been approved or used in the clinic.…”

Section: Current Strategies For Improving the Properties Of Nanotechn...mentioning

confidence: 99%

The improving strategies and applications of nanotechnology-based drugs in hepatocellular carcinoma treatment

Ren,

Su,

Shi

et al. 2023

Front. Bioeng. Biotechnol.

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Hepatocellular carcinoma (HCC) is one of the leading causes of tumor-related death worldwide. Conventional treatments for HCC include drugs, radiation, and surgery. Despite the unremitting efforts of researchers, the curative effect of HCC has been greatly improved, but because HCC is often found in the middle and late stages, the curative effect is still not satisfactory, and the 5-year survival rate is still low. Nanomedicine is a potential subject, which has been applied to the treatment of HCC and has achieved promising results. Here, we summarized the factors affecting the efficacy of drugs in HCC treatment and the strategies for improving the efficacy of nanotechnology-based drugs in HCC, reviewed the recent applications’ progress on nanotechnology-based drugs in HCC treatment, and discussed the future perspectives and challenges of nanotechnology-based drugs in HCC treatment.

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“…Researchers successfully used liposomes to deliver therapeutic proteins such as antibodies, cytokines, and enzymes into mammalian cells. The phospholipid bilayer could retain the biological activity of proteins in the cavity, which could shield the damage to the extracellular matrix and endo/lysosomes in the cell to proteins [ 98 , 99 , 100 ]. These liposomes enter the cell through the endocytosis-mediated pathway.…”

Section: Nanocarriers-mediated Protein Deliverymentioning

confidence: 99%

Recent Progress of Rational Modified Nanocarriers for Cytosolic Protein Delivery

Sun

et al. 2023

Pharmaceutics

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Therapeutic proteins garnered significant attention in the field of disease treatment. In comparison to small molecule drugs, protein therapies offer distinct advantages, including high potency, specificity, low toxicity, and reduced carcinogenicity, even at minimal concentrations. However, the full potential of protein therapy is limited by inherent challenges such as large molecular size, delicate tertiary structure, and poor membrane penetration, resulting in inefficient intracellular delivery into target cells. To address these challenges and enhance the clinical applications of protein therapies, various protein-loaded nanocarriers with tailored modifications were developed, including liposomes, exosomes, polymeric nanoparticles, and nanomotors. Despite these advancements, many of these strategies encounter significant issues such as entrapment within endosomes, leading to low therapeutic efficiency. In this review, we extensively discussed diverse strategies for the rational design of nanocarriers, aiming to overcome these limitations. Additionally, we presented a forward-looking viewpoint on the innovative generation of delivery systems specifically tailored for protein-based therapies. Our intention was to offer theoretical and technical support for the development and enhancement of nanocarriers capable of facilitating cytosolic protein delivery.

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Recent progress in nanomedicine-mediated cytosolic delivery

Abstract: For biomedical applications, various delivery methods have been studied, including penetrating peptides, stimuli-sensitive chemistry, endosomal escape, and fusogenic liposome for enhancing the cytosolic delivery efficiency of biomolecules.

Cited by 15 publications

References 71 publications

Shining a light on cells: amine-passivated fluorescent carbon dots as bioimaging nanoprobes

Shining a light on cells: amine-passivated fluorescent carbon dots as bioimaging nanoprobes

The improving strategies and applications of nanotechnology-based drugs in hepatocellular carcinoma treatment

Recent Progress of Rational Modified Nanocarriers for Cytosolic Protein Delivery

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