Recent Progress in Radiofrequency Ablation Therapy for Hepatocellular Carcinoma

Ikeda, Kenji; Osaki, Yukio; Nakanishi, Hiroyuki; Nasu, Akihiro; Kawamura, Yusuke; Jyoko, Koji; Sano, Tsuyoshi; Sunagozaka, Hajime; Uchino, Katsuyoshi; Minami, Yasunori; Saito, Yu; Nagai, Kazumasa; Inokuchi, Ryota; Kokubu, Shigehiro; Kudo, Masatoshi

doi:10.1159/000368148

Cited by 26 publications

(23 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In conventional RFA of other organs such as the liver, the active tip of the electrode is fixed to the center of the target tumor, which is ablated by the conducted heat; the ablation zone resulting from the fixed electrode technique is round in shape (23). However, as thyroid nodules are often ellipsoidal exophytic from the thyroid gland, they are difficult to ablate using the fixed technique.…”

Section: Basic Techniques Of Thyroid Rfamentioning

confidence: 99%

See 1 more Smart Citation

Thyroid Radiofrequency Ablation: Updates on Innovative Devices and Techniques

et al. 2017

View full text Add to dashboard Cite

Radiofrequency ablation (RFA) is a well-known, effective, and safe method for treating benign thyroid nodules and recurrent thyroid cancers. Thyroid-dedicated devices and basic techniques for thyroid RFA were introduced by the Korean Society of Thyroid Radiology (KSThR) in 2012. Thyroid RFA has now been adopted worldwide, with subsequent advances in devices and techniques. To optimize the treatment efficacy and patient safety, understanding the basic and advanced RFA techniques and selecting the optimal treatment strategy are critical. The goal of this review is to therefore provide updates and analysis of current devices and advanced techniques for RFA treatment of benign thyroid nodules and recurrent thyroid cancers.

show abstract

Section: Basic Techniques Of Thyroid Rfamentioning

confidence: 99%

“…Bipolar RFA has been used in liver, kidney, and muscle treatments (23). Unlike monopolar electrodes, use of bipolar electrodes simplifies the procedure, as grounding pads are not required.…”

Section: Updates Of Thyroid Rfamentioning

confidence: 99%

Thyroid Radiofrequency Ablation: Updates on Innovative Devices and Techniques

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This approach often can be applied through open surgical, laparoscopic, or percutaneous techniques. RFA can target the tumor within the parenchyma through image guidance and spare the normal surrounding liver [8]. Treatment outcomes indicate that RFA is a safe and efficient method of tumor ablation with low morbidity and mortality rates, and maximal perseveration of normal liver parenchyma [9].…”

Section: Introductionmentioning

confidence: 99%

Potential of Radiofrequency Ablation in Combination with Immunotherapy in the Treatment of Hepatocellular Carcinoma

Staveley-O’Carroll

Kimchi

2016

J Clin Trials

View full text Add to dashboard Cite

Radiofrequency ablation (RFA) is an important treatment option for patients with early hepatocellular carcinoma (HCC). RFA offers a reliable, reproducible modality to effectively treat hepatic lesions with minimal collateral damage to the surrounding hepatic parenchyma. In addition to traditional open operative techniques, RFA can be performed percutaneously or laparoscopically to minimize the physiologic insult to the patient. Due to the concomitant hepatic damage and dysfunction that often is present in patients with HCC these factors make RFA a frequently utilized therapeutic option. However, RFA is most efficacious in treating smaller tumors (≤ 2 cm), particularly when an ablation margin of ≥ 4–5 mm can be obtained. RFA has diminishing utility in larger tumors, resulting in reduced three and five year overall survival rates when compared to surgical resection. Multimodal approaches to include RFA with other standard and investigational approaches have become a subject of recent interest. RFA capably produces cellular destruction causing liberation of a substantial amount of antigens, many of which are tumor-specific providing a favorable environment for immune recognition. We propose that utilizing an immunotherapeutic approach in conjunction with RFA is the next logical step in the treatment of HCC. In this review, we summarize how RFA modulates antitumor immunity and works in concert with immunotherapy in the treatment of HCC. The information provided is expected to help the future design of novel RFA-integrated immunotherapies which are able to generate durable and powerful antitumor immune response to achieve optimal tumor control.

show abstract

“…No ground pad is required, so it does not cause thermal injury to the skin [9], and the system can also be used safely in patients with cardiac pacemakers [18]. One of the greatest advantages of the multipolar system is its ability to achieve a large ablative area in a short period of time as planned, because it is not prone to a vascular heat sink effect that would result in unexpected reduction of the ablative area [19,20].…”

Section: Discussionmentioning

confidence: 99%

Short-Term Results of Laparoscopic Radiofrequency Ablation Using a Multipolar System for Localized Hepatocellular Carcinoma

et al. 2016

View full text Add to dashboard Cite

Background and Aim: Multipolar radiofrequency ablation (RFA) is feasible for the treatment of hepatocellular carcinoma (HCC) for which a large ablative area is planned, and it imposes a light physical burden on patients. Multipolar RFA via the percutaneous approach is performed in the majority of cases, but the efficacy of multipolar RFA with a laparoscopic approach has rarely been studied. This study aimed to evaluate the efficacy and safety of multipolar laparoscopic RFA (LRA) for localized HCC over the short term. Methods: From January 2014 to January 2016, 77 consecutive patients with 130 HCCs treated by multipolar LRA were assessed. One to three bipolar needle applicators were inserted under laparoscopic ultrasonography guidance, regardless of tumor location. We intended to achieve parallel insertions and no-touch ablation as much as possible. Results: The median size of the main tumor was 22 mm (range, 10-42 mm). The median follow-up time was 13.6 months (range, 3.1-24.8 months). In all cases, a sufficient ablative area was obtained as planned, without thermal injury of adjacent organs. During the follow-up period, all patients were alive with no local tumor progression, while intrahepatic recurrence distant from the primary site occurred in 7 patients. The 2-year local tumor progression-free survival rate and overall cancer-free survival rate were 100 and 81.6%, respectively. There were no procedural major complications caused prolonging the hospitalization, and all patients were discharged without subjective symptoms 4-7 days after LRA. Conclusions: Multipolar LRA was efficacious in the treatment of localized HCCs by safely achieving a good ablative area.

show abstract

Recent Progress in Radiofrequency Ablation Therapy for Hepatocellular Carcinoma

Cited by 26 publications

References 9 publications

Thyroid Radiofrequency Ablation: Updates on Innovative Devices and Techniques

Thyroid Radiofrequency Ablation: Updates on Innovative Devices and Techniques

Potential of Radiofrequency Ablation in Combination with Immunotherapy in the Treatment of Hepatocellular Carcinoma

Short-Term Results of Laparoscopic Radiofrequency Ablation Using a Multipolar System for Localized Hepatocellular Carcinoma

Contact Info

Product

Resources

About