Recent Progress in Solid‐Phase Total Synthesis of Naturally Occurring Small Peptides

Abstract

Many naturally occurring small peptides have significant therapeutic properties. Total synthesis of these peptides is not only helpful in the identification of their structures and providing methods to synthesize their analogues, but also contributes to their biosynthetic studies. As solid‐phase synthesis simplifies the tedious and time‐consuming isolation of intermediates, it has been widely applied in peptide synthesis. This review has highlighted the recent progress in solid‐phase total synthesis of both linear and cyclic naturally occurring small peptides from 2014 to July 2021.

Total syntheses of surugamides and thioamycolamides toward understanding their biosynthesis

“…The linear Fig. 1 Proposed structures of surugamides A-E (1-5) and structures of surugamide F (6) peptide 7 was then synthesized by the solid-phase peptide synthesis [12].…”

“…The cyclization site was definitively determined from the genome analysis. The linear peptide 7 was then synthesized by the solid-phase peptide synthesis [ 12 ].

Fig.

…”

Unveiling the Configurational Landscape of Carbamate: Paving the Way for Designing Functional Sequence-Defined Polymers

“…The primary amino acid sequence determines how a protein folds into the desired structure to perform its function. The protein folding and hierarchical self-assembly of biopolymers are achieved through the precise control of primary sequences. , Therefore, significant efforts have been devoted to understand how the structures are controlled in nature and to achieve de novo design of new functional materials through the primary sequence control. , With the development of sequence-defined peptide synthesis methods, − the field of peptide- and protein-based functional nanomaterials has flourished to obtain sophisticated structures and fine-tuning functions. ,− …”

Unveiling the Configurational Landscape of Carbamate: Paving the Way for Designing Functional Sequence-Defined Polymers

“…1,2 Therefore, significant efforts have been devoted to understand how the structures are controlled in nature and to achieve de novo design of new functional materials through the primary sequence control. 3,4 With the development of sequence-defined peptide synthesis methods, [5][6][7][8][9] the field of peptide-and protein-based functional nanomaterials has flourished to obtain sophisticated structures and fine-tuning functions. 1,[10][11][12] Although polypeptides are a promising class of materials, several challenges remain.…”