2024
DOI: 10.1002/smo.20240030
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Recent progress in stimuli‐activable metallo‐prodrugs for cancer therapy

Jinzhe Liang,
Fangmian Wei,
Hui Chao

Abstract: The clinical approval of platinum‐based drugs has prompted the development of novel metallo‐complexes during the last several decades, while severe problems, especially for poor water solubility, drug resistance and toxicity in patients, greatly hindered the clinical trials and curative efficacy. To address these issues, the concept of metallo‐prodrugs has been proposed for oncology. Some stimuli‐activable metallo‐prodrugs provide new insights for designing and preparing site‐specific prodrugs with maximized t… Show more

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