Recent Progress in Stimuli-Induced Morphology Transformations of Block Copolymer Assemblies

Zeng, Haoxiang; Roberts, Derrick A.

doi:10.1071/ch21200

Cited by 4 publications

(5 citation statements)

References 81 publications

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“…[3][4][5][6] In particular, block copolymers (BCPs) are capable of creating a diverse array of nanostructures. [7][8][9] BCPs consist of two or more covalently-linked segments, whose chemical incompatibility results in microphase separation. Furthermore, driven by a difference in solubility, they are capable of forming a variety of supramolecular nanostructures in solution.…”

Section: Introductionmentioning

confidence: 99%

Photoresponsive block copolymer nanostructures through implementation of arylazopyrazoles

Ziegler,

Schlichter,

Post

et al. 2024

Preprint

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Responsive nanomaterials that can undergo reversible changes in morphology are interesting for the development of functional materials that interact with and respond to their environment. Amphiphilic block copolymers are well known for their ability to create a wide range of supramolecular nanostructures in solution. Arylazopyrazoles (AAPs) are versatile molecular photoswitches, which change their configuration and hydrophobicity via irradiation with UV light (365 nm, Z isomer, less hydrophobic) and green light (520 nm, E isomer, more hydrophobic). In this work, photoswitchable block copolymers containing arylazopyrazole tetraethylene glycol methacrylate (AAPMA) and oligo(ethylene glycol) methacrylate (OEGMA) forming amphiphilic POEGMA b PAAPMA with varying block lengths are prepared by RAFT polymerization. The photochemical properties of AAP persist in the polymers. Due to their amphiphilic structure, the polymers self-assemble into supramolecular morphologies in water. Remarkably, photoisomerization results in a reversible change in the self-assembly behavior. Specifically, spherical and cylindrical micelles are observed for POEGMA33-b-PAAPMA47 when illuminated under green or UV light during assembly. Furthermore, the morphology of assembled structures can be reversibly switched by subsequent irradiation with UV and green light.

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Section: Introductionmentioning

confidence: 99%

Photoresponsive block copolymer nanostructures through implementation of arylazopyrazoles

Ziegler,

Schlichter,

Post

et al. 2024

Preprint

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“…[51] With indepth studies, PISA has become a hot research area in the field of polymer science, attracting a lot of attention. Recently, a series of excellent reviews summarized the progress of PISA from implement technique, [52][53][54][55][56][57] materials characteris tics, [44,[58][59][60][61][62][63][64][65][66] impact factors, [67][68][69][70][71][72][73][74] to application areas, [43,75,76] which highlight the advantages of PISA in fabricating polymerbased nanostructures. However, the important class of biomaterials is underrepresented yet as only few overviews about the generation of PBBNs via the PISA technique have been published.…”

Section: Introductionmentioning

confidence: 99%

Polymerization‐Induced Self‐Assembly: An Emerging Tool for Generating Polymer‐Based Biohybrid Nanostructures

Qiu

Han

Xing

et al. 2023

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The combination of biomolecules and synthetic polymers provides an easy access to utilize advantages from both the synthetic world and nature. This is not only important for the development of novel innovative materials, but also promotes the application of biomolecules in various fields including medicine, catalysis, and water treatment, etc. Due to the rapid progress in synthesis strategies for polymer nanomaterials and deepened understanding of biomolecules’ structures and functions, the construction of advanced polymer‐based biohybrid nanostructures (PBBNs) becomes prospective and attainable. Polymerization‐induced self‐assembly (PISA), as an efficient and versatile technique in obtaining polymeric nano‐objects at high concentrations, has demonstrated to be an attractive alternative to existing self‐assembly procedures. Those advantages induce the focus on the fabrication of PBBNs via the PISA technique. In this review, current preparation strategies are illustrated based on the PISA technique for achieving various PBBNs, including grafting‐from and grafting‐through methods, as well as encapsulation of biomolecules during and subsequent to the PISA process. Finally, advantages and drawbacks are discussed in the fabrication of PBBNs via the PISA technique and obstacles are identified that need to be overcome to enable commercial application.

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“…With increasing demands on block copolymer assemblies to perform specific functions such as transformations in morphology , or triggered release of molecules, , there has been growing interest in the incorporation of stimuli-responsive polymers into block copolymers and their assemblies. For example, polymer blocks can be reversibly switched between hydrophilic and hydrophobic states through changes in pH, , temperature, , or CO 2 concentration. , Chemical degradation induced by stimuli such as light , or acid , can also be used to degrade individual blocks or the linkages between blocks.…”

Section: Introductionmentioning

confidence: 99%

“…5 Furthermore, there has been substantial interest in the development and study of block copolymers in solution for nanomedicine. 6 With increasing demands on block copolymer assemblies to perform specific functions such as transformations in morphology 7,8 or triggered release of molecules, 9,10 there has been growing interest in the incorporation of stimuliresponsive polymers into block copolymers and their assemblies. For example, polymer blocks can be reversibly switched between hydrophilic and hydrophobic states through changes in pH, 11,12 temperature, 13,14 or CO 2 concentration.…”

Section: ■ Introductionmentioning

confidence: 99%

Self-immolative Amphiphilic Diblock Copolymers with Individually Triggerable Blocks

Liang

Gillies

2022

ACS Polym. Au

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Self-immolative polymers are a growing class of degradable polymers that undergo end-to-end depolymerization after the stimuli-responsive cleavage of an end-cap or backbone unit. Their incorporation into amphiphilic block copolymers can lead to functions such as the disintegration of copolymer nanoassemblies when depolymerization is triggered. However, diblock copolymers have not yet been developed where both blocks are self-immolative. Described here is the synthesis, self-assembly, and triggered depolymerization of self-immolative block copolymers with individually triggerable hydrophilic and hydrophobic blocks. Neutral and cationic hydrophilic polyglyxoylamides (PGAm) with acid-responsive end caps were synthesized and coupled to an ultraviolet (UV) light-triggerable poly(ethyl glyoxylate) (PEtG) hydrophobic block. The resulting block copolymers self-assembled to form nanoparticles in aqueous solution, and their depolymerization in response to acid and UV light was studied by techniques including light scattering, NMR spectroscopy, and electron microscopy. Acid led to selective depolymerization of the PGAm blocks, leading to aggregation, while UV light led to selective depolymerization of the PEtG block, leading to disassembly. This self-immolative block copolymer system provides an enhanced level of control over smart copolymer assemblies and their degradation.

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Recent Progress in Stimuli-Induced Morphology Transformations of Block Copolymer Assemblies

Cited by 4 publications

References 81 publications

Photoresponsive block copolymer nanostructures through implementation of arylazopyrazoles

Photoresponsive block copolymer nanostructures through implementation of arylazopyrazoles

Polymerization‐Induced Self‐Assembly: An Emerging Tool for Generating Polymer‐Based Biohybrid Nanostructures

Self-immolative Amphiphilic Diblock Copolymers with Individually Triggerable Blocks

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