Recent progress in stimuli-responsive polymeric micelles for targeted delivery of functional nanoparticles

Cao, Zhonglin; Zuo, Xiaoling; Liu, Xiaochen; Xu, Gaixia; Yong, Ken-Tye

doi:10.1016/j.cis.2024.103206

Advances in Colloid and Interface Science

2024

DOI: 10.1016/j.cis.2024.103206

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Recent progress in stimuli-responsive polymeric micelles for targeted delivery of functional nanoparticles

Zhonglin Cao,

Xiaoling Zuo,

Xiaochen Liu

et al.

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Cited by 5 publications

References 172 publications

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Acta Pharmaceutica Sinica B

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Solubilization techniques used for poorly water-soluble drugs

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Advanced Application of Polymer Nanocarriers in Delivery of Active Ingredients from Traditional Chinese Medicines

Zhai,

Niu,

et al. 2024

Molecules

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Active ingredients from Traditional Chinese Medicines (TCMs) have been a cornerstone of healthcare for millennia, offering a rich source of bioactive compounds with therapeutic potential. However, the clinical application of TCMs is often limited by challenges such as poor solubility, low bioavailability, and variable pharmacokinetics. To address these issues, the development of advanced polymer nanocarriers has emerged as a promising strategy for the delivery of TCMs. This review focuses on the introduction of common active ingredients from TCMs and the recent advancements in the design and application of polymer nanocarriers for enhancing the efficacy and safety of TCMs. We begin by discussing the unique properties of TCMs and the inherent challenges associated with their delivery. We then delve into the types of polymeric nanocarriers, including polymer micelles, polymer vesicles, polymer hydrogels, and polymer drug conjugates, highlighting their application in the delivery of active ingredients from TCMs. The main body of the review presents a comprehensive analysis of the state-of-the-art nanocarrier systems and introduces the impact of these nanocarriers on the solubility, stability, and bioavailability of TCM components. On the basis of this, we provide an outlook on the future directions of polymer nanocarriers in TCM delivery. This review underscores the transformative potential of polymer nanocarriers in revolutionizing TCM delivery, offering a pathway to harness the full therapeutic potential of TCMs while ensuring safety and efficacy in a modern medical context.

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Recent progress in stimuli-responsive polymeric micelles for targeted delivery of functional nanoparticles

Cited by 5 publications

References 172 publications

Solubilization techniques used for poorly water-soluble drugs

Solubilization techniques used for poorly water-soluble drugs

ROS sensitive micelles of carbon dioxide based amphiphilic polymer for delivery of avermectin

Advanced Application of Polymer Nanocarriers in Delivery of Active Ingredients from Traditional Chinese Medicines

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