“…(1) The development of robust models of irradiation hardening and transition temperature shift (TTS) in RPV steels based on the evolution of several predominant defect types in irradiated RPV steels, including precipitates (e.g., Cu rich for high Cu steel, Mn-Ni rich in low-Cu steels at high fluences), stable matrix defects, and unstable matrix defects (UMDsvacancy agglomerates, partially affiliated with Cu and/or other alloys) [34][35][36][37][38]44,48,50,51,[74][75][76][77][78] (2) The evolution of the Cu-Ni-Mn precipitate population by radiation-enhanced diffusion processes and the employment of rate theory models calibrated with extensive data to predict that evolution [27][28][29]31,32,35] (3) The role of Cu, Mn, Ni in mitigating the damage microstructure [31][32][33][34][35]45,50,71,73,74] -for instance: a. a threshold level of bulk Cu before the onset of hardening;…”