Recent progress in surface-enhanced Raman spectroscopy-based biosensors for the detection of extracellular vesicles

Zheng, Hong; Ding, Qin; Li, Chen; Chen, Wei; Chen, Xiaoqiang; Lin, Qin; Wang, Desheng; Weng, Youliang; Lin, Duo

doi:10.1039/d2ay01339h

Cited by 8 publications

(1 citation statement)

References 60 publications

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“…In agreement with the functions of tumor cells, CAFs frequently play a role in the TME by secreting EVs with the purpose of building a bridge between CAFs and distant metastatic organs. As a type of substance for communications and transmission in organisms [58][59][60], EVs exert fundamental effects on governing the biological processes of PMN formation mediated through CAFs. For instance, a study using salivary adenoid cystic carcinoma (SACC) model elucidated that the EVs derived from CAFs were capable of propelling the PMN formation in the lung tissues of SACC model, and the EVs derived from CAFs presented a stronger phenotype to give rise to matrix remodeling in the distant metastatic organs in comparison to EVs from SACC.…”

Section: Mechanisms Of Cafs Regulating Pmn Formationmentioning

confidence: 99%

Fibroblasts: invigorated targets in pre-metastatic niche formation

Han,

Qian,

Song

et al. 2024

Int. J. Biol. Sci.

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At present, tumor metastasis still remains the leading contributor to high recurrence and mortality in cancer patients. There have been no clinically effective therapeutic strategies for treating patients with metastatic cancer. In recent years, a growing body of evidence has shown that the pre-metastatic niche (PMN) plays a crucial role in driving tumor metastasis. Nevertheless, a clear and detailed understanding of the formation of PMN is still lacking given the fact that PMN formation involves in a wealth of complicated communications and underlying mechanisms between primary tumors and metastatic target organs. Despite that the roles of numerous components including tumor exosomes and extracellular vesicles in influencing the evolution of PMN have been well documented, the involvement of cancer-associated fibroblasts (CAFs) in the tumor microenvironment for controlling PMN formation is frequently overlooked. It has been increasingly recognized that fibroblasts trigger the formation of PMN by virtue of modulating exosomes, metabolism and so on. In this review, we mainly summarize the underlying mechanisms of fibroblasts from diverse origins in exerting impacts on PMN evolution, and further highlight the prospective strategies for targeting fibroblasts to prevent PMN formation.

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Section: Mechanisms Of Cafs Regulating Pmn Formationmentioning

confidence: 99%