Recent progress in the application of N-halo reagents in the synthesis of heterocyclic compounds

Convenient One-Pot Synthesis of Sulfonamides from Thiols and Disulfides Using 1,3-Dichloro-5,5-dimethylhydantoin (DCH)

“…Herein, as part of our ongoing study on the application of N-halo reagents in organic synthesis, [13][14][15][16][17] we would like to present the direct convenient one-pot synthesis of sulfonamides from thiols and disulfides using 1,3-dichloro-5,5-dimethylhydantoin (DCH) under mild conditions (Scheme 1).…”

Kinetics and Mechanism of Micellar Catalyzed Oxidation of Dextrose by N-Bromosuccinimide in H2SO4 Medium

“…It was found that the value of rate constant decreases with increasing concentration of H 2 SO 4 acid as it is shown in Figure 4, Table 2. 2 ]. Mercuric acetate was added to the reaction mixture as scavenger to eliminate Br − formed in the reaction which could have produced Br 2 in the reaction.…”

“…The versatile nature of N-halomides due to their ability to produce halonium cations, hypohalite species, and nitrogen anion, which act as both bases and nucleophiles [1]. N-haloamides, well known as N-bromosuccinimide, is a very important member of this class of compounds and has received a considerable attention as an oxidizing agent for a wide range of functional groups in both acidic and alkaline media [2][3][4].…”

Facile and efficient approach for the synthesis of spirocyclopropylbarbiturates and 3-substituted-1,1,2,2-tetracyanocyclopropanes using N-halosulfonamides

“…In this regard, a large number of compounds called N -halo reagents have been widely used in organic transformations and in the chemistry of natural compounds [25]. Some halogenating agents require special equipment and techniques because of their explosive, toxic, unstable, and hygroscopic qualities but N -halo sulfonamides are easy to handle and only half of their halogens are consumed, as in the case of elemental halogen [26].…”