Recent progress in the development of small-molecule double-locked logic gate fluorescence probes

Zhang, Xiaoting; Xiu, Tiancong; Wang, Hui; Wang, Hongtong; Li, Ping; Tang, Bo

doi:10.1039/d3cc03492e

Chem. Commun.

2023

DOI: 10.1039/d3cc03492e

|View full text |Cite

Recent progress in the development of small-molecule double-locked logic gate fluorescence probes

Xiaoting Zhang,

Tiancong Xiu,

Hui Wang

et al.

Abstract: Recent progress in the development of small-molecule double-locked logic gate fluorescence probes.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article6

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 14 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AND molecular logic gate fluorescent probes, receiving two or more biomarkers but only giving a single signal output, provide a capable strategy for constructing PA probes to achieve precise imaging of deep-seated tumors. − As a consideration of this, AND-gate PA probes have recently been developed for precise in vivo imaging of localized disease markers. − For instance, Zhang and co-workers reported a nitric oxide (NO) and acidity dual-stimuli responsive theranostic nanoprobe to improve the specificity of cancer theranostics . Zhang et al proposed a double-locked PA probe that could noninvasively and accurately image CTB within lipid-laden plaques to evaluate plaque vulnerability characteristics .…”

mentioning

confidence: 99%

An AND-Gate Photoacoustic Probe for Cys and H₂S Precise Photoacoustic Sensing in Localized Tumors

Li,

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

Photoacoustic (PA) tomography has shown many promising aspects in noninvasive and precise imaging of deep-localized biomarkers. However, these traditional single-locked PA probes always face challenges in precise PA imaging with high specificity. Here, we report a novel AND-gate photoacoustic probe, BAE, to improve tumor imaging accuracy via the combination of two tumor-associated biomarkers, cysteine (Cys) and hydrogen sulfide (H 2 S). Only when Cys and H 2 S are concurrently introduced into the detection system does the absorption of BAE red-shift from the initial 680 to 810 nm, thereby showing a 5.29-fold enhancement in its PA signal at 810 nm. The good specificity of BAE is proven, since an obvious PA signal could be observed only in the solution containing both Cys and H 2 S and was not affected by other reactive sulfur species. After being taken up by tumors with the assistance of a nanomicelle, the AND-gate PA probe BAE was applied for dynamic real-time monitoring of Cys and H 2 S in vivo, achieving precise identification of tumors. This AND-gate PA probe provides a potential technical tool for precise sensing analysis of deep-seated diseases.

show abstract

mentioning

confidence: 99%

An AND-Gate Photoacoustic Probe for Cys and H₂S Precise Photoacoustic Sensing in Localized Tumors

Li,

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

show abstract

Dual‐Locked Fluorescent Probes Activated by Aminopeptidase N and the Tumor Redox Environment for High‐Precision Imaging of Tumor Boundaries

Shen,

Li,

Zhou

et al. 2024

Angewandte Chemie

View full text Add to dashboard Cite

Clear delineation of tumor margins is essential for accurate resection and decreased recurrence rate in the clinic. Fluorescence imaging is emerging as a promising alternative to traditional visual inspection by surgeons for intraoperative imaging. However, traditional probes lack accuracy in tumor diagnosis, making it difficult to depict tumor boundaries accurately. Herein, we proposed an offensive and defensive integration (ODI) strategy based on the “attack systems (invasive peptidase) and defense systems (reductive microenvironment)” of multi‐dimensional tumor characteristics to design activatable fluorescent probes for imaging tumor boundaries precisely. Screened out from a series of ODI strategy‐based probes, ANQ performed better than traditional probes based on tumor unilateral correlation by distinguishing between tumor cells and normal cells and minimizing false‐positive signals from living metabolic organs. To further improve the signal‐to‐background ratio in vivo, derivatized FANQ, was prepared and successfully applied to distinguish orthotopic hepatocellular carcinoma tissues from adjacent tissues in mice models and clinical samples. This work highlights an innovative strategy to develop activatable probes for rapid diagnosis of tumors and high‐precision imaging of tumor boundaries, providing more efficient tools for future clinical applications in intraoperative assisted resection.

show abstract

Dual‐Locked Fluorescent Probes Activated by Aminopeptidase N and the Tumor Redox Environment for High‐Precision Imaging of Tumor Boundaries

Shen,

Li,

Zhou

et al. 2024

Angew Chem Int Ed

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Recent progress in the development of small-molecule double-locked logic gate fluorescence probes

Abstract: Recent progress in the development of small-molecule double-locked logic gate fluorescence probes.

Cited by 14 publications

References 52 publications

An AND-Gate Photoacoustic Probe for Cys and H₂S Precise Photoacoustic Sensing in Localized Tumors

An AND-Gate Photoacoustic Probe for Cys and H₂S Precise Photoacoustic Sensing in Localized Tumors

Dual‐Locked Fluorescent Probes Activated by Aminopeptidase N and the Tumor Redox Environment for High‐Precision Imaging of Tumor Boundaries

Dual‐Locked Fluorescent Probes Activated by Aminopeptidase N and the Tumor Redox Environment for High‐Precision Imaging of Tumor Boundaries

Contact Info

Product

Resources

About

Recent progress in the development of small-molecule double-locked logic gate fluorescence probes

Abstract: Recent progress in the development of small-molecule double-locked logic gate fluorescence probes.

Cited by 14 publications

References 52 publications

An AND-Gate Photoacoustic Probe for Cys and H2S Precise Photoacoustic Sensing in Localized Tumors

An AND-Gate Photoacoustic Probe for Cys and H2S Precise Photoacoustic Sensing in Localized Tumors

Dual‐Locked Fluorescent Probes Activated by Aminopeptidase N and the Tumor Redox Environment for High‐Precision Imaging of Tumor Boundaries

Dual‐Locked Fluorescent Probes Activated by Aminopeptidase N and the Tumor Redox Environment for High‐Precision Imaging of Tumor Boundaries

Contact Info

Product

Resources

About

An AND-Gate Photoacoustic Probe for Cys and H₂S Precise Photoacoustic Sensing in Localized Tumors

An AND-Gate Photoacoustic Probe for Cys and H₂S Precise Photoacoustic Sensing in Localized Tumors