Recent progress in the development of coumarin derivatives as potent anti‐HIV agents

Abstract

Numerous plant-derived compounds have been evaluated for inhibitory effects against HIV replication, and some coumarins have been found to inhibit different stages in the HIV replication cycle. This review article describes recent progress in the discovery, structure modification, and structure-activity relationship studies of potent anti-HIV coumarin derivatives. A dicamphanoyl-khellactone (DCK) analog, which was discovered and developed in our laboratory, and calanolide A are currently in preclinical studies and clinical trials, respectively.

Chemical Diversity in Nature Produces Potent Drugs of Various Ailments; Natural Products

“…It has also been reported to have glycosidase inhibitory activity [37]. Coriandrin isolated from the coriander Coriandrum sativum, possessed anti-HIV and other anti-viral activities [38]. …”

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

“…Benzopyrones are an important class of oxygenated heterocycles, widely distributed in plants, including edible vegetables and fruits [79] and many of them have broad and interesting ranges of biological activities [80][81][82][83]. The two more important benzopyrone derivatives are the chromones and coumarins.…”

Is Chronic Combination Therapy of HAART and α-ZAM, Herbal Preparation for HIV Infection Safe?

“…Coumarin derived herbal remedies decreased drug resistance resulting from HIV mutation associated with non-nucleoside analogue-nevirapine [19,20] . Some herbal remedies have also shown to decreased toxicity associated with HAART.…”