Recent progress in the effect of ferroptosis of HSCs on the development of liver fibrosis

Tang, Rui; Luo, Jing; Zhu, Xiaoxia; Miao, Pengyu; Tang, Hong; Jian, Yue; Ruan, Sibei; Ling, Feng; Tang, Mingxi

doi:10.3389/fmolb.2023.1258870

Cited by 5 publications

(2 citation statements)

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“…Ferroptosis induces programmed cell death by catalyzing the lipid peroxidation of unsaturated fatty acids highly expressed on the cell membrane, under the action of divalent iron or ester oxygenase ( 73 ). Lipid metabolism disorder is closely related to ferroptosis.…”

Section: Hbxip and Tumorsmentioning

confidence: 99%

Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Cheng,

Guo,

Zou

et al. 2024

Mol Med Rep

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Hepatitis B X-interacting protein (HBXIP) is a membrane protein located on the lysosomal surface and encoded by the Lamtor gene. It is expressed by a wide range of tumor types, including breast cancer, esophageal squamous cell carcinoma and hepatocellular carcinoma, and its expression is associated with certain clinicopathological characteristics. In the past decade, research on the oncogenic mechanisms of HBXIP has increased and the function of HBXIP in normal cells has been gradually elucidated. In the present review, the following was discussed: The normal physiological role of the HBXIP carcinogenic mechanism; the clinical significance of high levels of HBXIP expression in different tumors; HBXIP regulation of transcription, post-transcription and post-translation processes in tumors; the role of HBXIP in improving the antioxidant capacity of tumor cells; the inhibition of ferroptosis of tumor cells and regulating the metabolic reprogramming of tumor cells; and the role of HBXIP in promoting the malignant progression of tumors. In conclusion, the present review summarized the existing knowledge of HBXIP, established its carcinogenic mechanism and discussed future related research on HBXIP.

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Section: Hbxip and Tumorsmentioning

confidence: 99%

Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Cheng,

Guo,

Zou

et al. 2024

Mol Med Rep

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“…In summary, abnormal lipid metabolism in liver cancer not only affects the biological behavior of tumor cells, but also further promotes the development of liver cancer by affecting the tumor microenvironment[ 110 ]. Therefore, a thorough understanding of the role and mechanism of lipid metabolism in liver cancer is of great significance for the discovery of new therapeutic targets and strategies.…”

Section: The Significance Of Lipid Peroxidation and Abnormal Metaboli...mentioning

confidence: 99%

Research progress of ferroptosis regulating lipid peroxidation and metabolism in occurrence and development of primary liver cancer

Shu,

Lao,

Qiu

2024

World J Gastrointest Oncol

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As a highly aggressive tumor, the pathophysiological mechanism of primary liver cancer has attracted much attention. In recent years, factors such as ferroptosis regulation, lipid peroxidation and metabolic abnormalities have emerged in the study of liver cancer, providing a new perspective for understanding the development of liver cancer. Ferroptosis regulation, lipid peroxidation and metabolic abnormalities play important roles in the occurrence and development of liver cancer. The regulation of ferroptosis is involved in apoptosis and necrosis, affecting cell survival and death. Lipid peroxidation promotes oxidative damage and promotes the invasion of liver cancer cells. Metabolic abnormalities, especially the disorders of glucose and lipid metabolism, directly affect the proliferation and growth of liver cancer cells. Studies of ferroptosis regulation and lipid peroxidation may help to discover new therapeutic targets and improve therapeutic outcomes. The understanding of metabolic abnormalities can provide new ideas for the prevention of liver cancer, and reduce the risk of disease by adjusting the metabolic process. This review focuses on the key roles of ferroptosis regulation, lipid peroxidation and metabolic abnormalities in this process.

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