Recent progress in the field of glycoconjugates

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

“…The synthesis of long peptides with more than 50 residues is difficult by stepwise synthesis, due to the incomplete couplings and epimerisation. This leads to the formation of side products and a low yield of final product 30. Therefore, convergent (fragment-condensation) methods including on-resin linked glycopeptide and Lansbury aspartylation are applied as alternatives to overcome this problem.…”

Enzymatic synthesis and self-assembly of glycolipids: robust self-healing and wound closure performance of assembled soft materials

“…29 Nevertheless, the use of harsh reaction conditions, metal catalysts, formation of undesired products and intense purication steps limit the commercial value of glycolipids. [30][31][32] The present study details a facile method for the generation of glycolipids from inexpensive commercially available raw materials derived from renewable resources using an enzyme as a catalyst. Generally, enzyme-triggered reactions are desirable for the precise synthesis of glycolipids under mild reaction conditions, with control in stereo-and regioselectivities, structure, substrate and functional groups.…”

Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives

“…8 Various glycosides can be found in natural resources, mainly in the form of glycoconjugates, such as glycopeptides, glycolipids, and nucleic acids, where the saccharide moiety plays important role for their biological activity. 9 Considering that sugar moieties with polyhydroxyl groups have been extensively employed in drug design with the view to improve water solubility and to increase the interaction between receptors and guests for molecular recognition, 10,11 various novel monosaccharide-derived 1,2,3-triazoles were synthesized and their inhibiting activities for glycosidases, such as α-glucosidase, isomaltase, amyloglucosidase and β-glucosidase, 12 sweet almond β-glucosidase and yeast α-glucosidase, 13 or a-glucosidase (Saccharomyces cerevisiae), β-glucosidase (almonds), α-galactosidase (green coffee beans), β-galactosidase (Aspergillus oryzae), α-mannosidase (Canavalia ensiformis), β-mannosidase (snail acetone powder), and β-N-acetylglucosaminidase, 14 were tested. Others were tested against fucosidases, 15 trans-sialidase, 16 glycogen phosphorylase, 17 etc.…”