Recent Progress in Utilizing Upconversion Nanoparticles with Switchable Emission for Programmed Therapy

Zhang, Zhen; Liu, Yilin; Chen, Yongming

doi:10.1002/adtp.202100172

Cited by 6 publications

(4 citation statements)

References 97 publications

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“…Traditional UCNPs with fixed emissions pose limitations in performing multiple tasks, while utilizing UCNPs with orthogonal emissive emissions (OUCNPs) makes it possible to independently control the photoactivation of different functions by simply adjusting the external excitation light. This capability allows for precise temporal control and targeting of multiple specific biological processes (Boyer et al, 2010;Wang et al, 2014;Wang et al, 2015b;Huang et al, 2018;Zheng et al, 2018;Zhang et al, 2021b;Zhang and Zhang, 2021). So far, the synthesis of OUCNPs is complicated and tedious because different lanthanides need to be incorporated into the different shells (Boyer et al, 2010;Lai et al, 2014;Wang et al, 2015b;Li et al, 2016;Dong et al, 2017;Mei et al, 2019;Lei et al, 2020).…”

Section: Programmable Therapeuticsmentioning

confidence: 99%

Advancements in microemulsion-based fabrication of upconversion-mediated multifunctional materials

Zhang,

Mei,

Zhang

2024

Front. Photon.

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Upconversion nanoparticles (UCNPs) have experienced significant advancements, finding applications in diverse fields over the past decade. The growing demand for UCNP-based nanoplatforms with multifunctionality to address complex scenarios has led to the emergence of the microemulsion confined self-assembly method, which allows for the integration of different UCNPs or UCNPs with additional functional materials within a single entity, resulting in a nanoplatform that possesses a wide range of properties suitable for specific applications. This comprehensive review aimed to summarize recent developments in the design of UCNP assemblies using the microemulsion confined self-assembly method, which focused on exploring their applications in critical areas such as color encoding, bioimaging, and programmable therapeutics. Furthermore, the review acknowledged the existing limitations associated with the microemulsion confined self-assembly method and provided an in-depth discussion of potential solutions to overcome these challenges, aiming to foster further progress and innovation in the design and application of UCNP assemblies.

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Section: Programmable Therapeuticsmentioning

confidence: 99%

Advancements in microemulsion-based fabrication of upconversion-mediated multifunctional materials

Zhang,

Mei,

Zhang

2024

Front. Photon.

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“…Over the past decades, UCNP-based nanoplatform for PDT has achieved great success both in vitro and in vivo. [10][11][12][13][14][15][16][17][18][19][20][21] Theory for practical cancer treatment PDT calls for not only for suitable light source to excite PSs but also enough ROS production to ensure high treatment efficacy. So far until now, the fully developed and widely applied PSs, such as methylene blue, zinc phthalocyanine, and chlorine e6 (Ce6), which belong to type-II (energy transfer types) PSs, and oxygen are necessary during their ROS production process.…”

Section: Introductionmentioning

confidence: 99%

Type‐I‐Organic‐Photosensitizer‐Functionalized Upconversion Nanoparticles for Enhanced Photodynamic Therapy

Liu,

Wang,

et al. 2024

Advanced Therapeutics

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Photodynamic therapy (PDT) has achieved great progress in cancer treatment because it generates reactive oxygen species (ROS) in a non‐invasive manner. Nonetheless, the majority of light‐sensitive photosensitizers (PSs) are only sensitive to UV or visible light, suffering limitations such as phototoxicity (UV) and low tissue penetration capabilities (UV/visible). What is more, another impact factor, namely the hypoxic environment within a tumor always inhibits the production of ROS for treatment efficacy. To overcome these problems, herein, one new type‐I PSs containing selenium (Se6) was designed. Benefiting from the dual heavy atom effects of selenium and bromine, Se6 could produce short‐lived hydroxyl (•OH) and long‐lived superoxide anion (O2•−) under both normoxic and hypoxic conditions, which is superior to commonly used oxygen‐dependent type‐II PSs, such as Ce6, ZnPc. Combining Se6 and upconversion nanoparticles (UCNPs) with the ability to upconvert NIR light to UV/visible light could greatly overcome the tissue penetration depth, phototoxicity, and oxygen‐dependent limitation of the PDT process, which demonstrates a significant performance in vivo to achieve better therapy efficiency.This article is protected by copyright. All rights reserved

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“…Currently, optical imaging plays a vital role in the biomedical field, and up to now, many optical agents such as quantum dots, organic dyes, , and upconversion nanoparticles − have been applied to optical imaging and imaging-guided surgery. However, the imaging acquisition process is accompanied by an external light excitation at the same time, causing strong tissue autofluorescence, which consequently affects the imaging quantity and sensitivity, especially for in vivo imaging .…”

Section: Introductionmentioning

confidence: 99%

Microemulsion-Based Fabrication of Organic Nanocrystals for Persistent Phosphorescence Bioimaging

Zhou

Shen

Wang

et al. 2023

ACS Appl. Nano Mater.

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Persistent phosphorescence eliminates the need for light excitation and thus avoids the issue of autofluorescence, holding great promise in various fields. To achieve bright phosphorescence emission, many methods were developed to confine most organic persistent phosphorescent materials in a rigid environment aiming to quench nonradiative relaxation pathways; among them, the nanocrystal method is a good candidate which can rigidify the molecules as well as offer the desirable water dispersity and size for further bioapplications. However, the current efficient preparation of phosphorescent nanocrystals still remains challenging. This study reports an efficient microemulsion-based method for the fabrication of phosphorescent nanocrystals with a desired diameter in the nanosize range (below 200 nm), a high phosphorescence quantum yield of about 6.5%, and ultralong persistent phosphorescence to the timescale after the removal of the external light source, making it easy for the commercial imaging system to detect, which is suitable for practical bioimaging. Furthermore, the synthesized nanocrystals with biocompatibility were utilized directly for in vitro imaging, showing effective cellular uptake and bright phosphorescence emission, which provides a reasonable strategy to develop a phosphorescent nanocrystal for application.

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Recent Progress in Utilizing Upconversion Nanoparticles with Switchable Emission for Programmed Therapy

Cited by 6 publications

References 97 publications

Advancements in microemulsion-based fabrication of upconversion-mediated multifunctional materials

Advancements in microemulsion-based fabrication of upconversion-mediated multifunctional materials

Type‐I‐Organic‐Photosensitizer‐Functionalized Upconversion Nanoparticles for Enhanced Photodynamic Therapy

Microemulsion-Based Fabrication of Organic Nanocrystals for Persistent Phosphorescence Bioimaging

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