Recent progress of Ammonium chloride as catalyst in organic synthesis

Pal, Rammohan

doi:10.9790/5736-0428699

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…The N1-methyl/ethyl-2-nitroaniline 2a-b was synthesized by using 2-fluronitrobenzene 1, methylamine/ethylamine and DMF as solvent in microwave [22]. The nitro group of phenyl ring 2a-b was further reduced to amino group in presence zinc and ammonium chloride to give 3a-b [23].Compounds 3a-b/4a-b and lactic/mandelic acid 5a-b dissolved in methanol and reflux in microwave to give 6a-f.Then activation of carboxylic functional group of 6a-f was carried out by using thionyl…”

Section: Resultsmentioning

confidence: 99%

Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives.

Kankate¹,

Gide²,

Belsare³

2014

Orient J Chem

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Benzimidazole and piperazines are the important pharmacophores in the structures of many antifungal compounds. Further, the phenylmethanone are also a unique class of compounds whose antifungal profile is not much exploited. So to exploit their antifungal potential we have selected these three combinations and framed the novel parent structure for our research work. In this study a novel series of benzimidazoles derivatives was synthesized by microwave irradiation and characterized by 1 H NMR, 13 C NMR, Infra Red (IR), and Mass Spectroscopy (MS), and by elemental analysis. The screening of compound for in vitro (turbidimetric method) antifungal activity against C.albicans revealed activity in many of the compounds as comparable to that of ketoconazole.

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Section: Resultsmentioning

confidence: 99%

Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives.

Kankate¹,

Gide²,

Belsare³

2014

Orient J Chem

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ChemInform Abstract: Recent Progress of Ammonium Chloride as Catalyst in Organic Synthesis

Pal

2014

ChemInform

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NH₄Cl/Zn powder: An efficient, chemoselective reducing catalyst for the microwave‐assisted synthesis of 2,3‐disubstituted quinolines via tandem Knoevenagel condensation

Syed

Asiri

Shaheen³

2020

Journal of Heterocyclic Chem

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An efficient, a hitherto unreported, sustainable, and environmentally friendly microwave‐assisted synthesis of 2,3‐disubstituted quinolines by reductive cyclization of 2‐nitrobenzaldehydes and various active methylene compounds via tandem Knoevenagel condensation promoted by an efficient eco‐friendly, chemoselective reducing catalyst ammonium chloride (NH4Cl) and zinc powder was developed. This present methodology is a mild, green, efficient, and environmentally benign process as it eliminates the harsh reaction conditions, non‐volatile solvents, relatively expensive reagents, high catalyst loading, and also provides a number of other benefits like fast synthesis, simple reaction set‐up, and good to the excellent yield of the products.

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Recent progress of Ammonium chloride as catalyst in organic synthesis

Cited by 4 publications

References 14 publications

Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives.

Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives.

ChemInform Abstract: Recent Progress of Ammonium Chloride as Catalyst in Organic Synthesis

NH₄Cl/Zn powder: An efficient, chemoselective reducing catalyst for the microwave‐assisted synthesis of 2,3‐disubstituted quinolines via tandem Knoevenagel condensation

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Recent progress of Ammonium chloride as catalyst in organic synthesis

Cited by 4 publications

References 14 publications

Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives.

Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives.

ChemInform Abstract: Recent Progress of Ammonium Chloride as Catalyst in Organic Synthesis

NH4Cl/Zn powder: An efficient, chemoselective reducing catalyst for the microwave‐assisted synthesis of 2,3‐disubstituted quinolines via tandem Knoevenagel condensation

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Product

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NH₄Cl/Zn powder: An efficient, chemoselective reducing catalyst for the microwave‐assisted synthesis of 2,3‐disubstituted quinolines via tandem Knoevenagel condensation