Recent progress of antibacterial natural products: Future antibiotics candidates

Dai, Jiangkun; Han, Rui; Xu, Yujie; Li, Na; Wang, Junru; Dan, Wenjia

doi:10.1016/j.bioorg.2020.103922

Cited by 65 publications

(29 citation statements)

References 173 publications

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“…Antibacterial activity is one of the most common health benefits of naturally occurring products. A series of natural antibacterial compounds such as alkaloids, coumarins, terpenoids, steroids, phenolics and flavonoids have been subjected to in‐depth study 91 . Ethanol extract from E. dulcis corm peel exerts higher inhibitory effects against Staphylococcus aureus and Escherichia coli than the counterpart derived from corm pulp, 16 which has been further confirmed by Zhan et al .…”

Section: Health Benefitsmentioning

confidence: 82%

Eleocharis dulcis corm: phytochemicals, health benefits, processing and food products

Zhang

et al. 2021

J Sci Food Agric

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Eleocharis dulcis, an aquatic plant belonging to Cyperaceae family, is indigenous to Asia, and also occurs in tropical Africa and Australia. The edible corm part of E. dulcis is a commonly consumed aquatic vegetable with a planting area of 44.46 × 103 hm2 in China. This work aims to explore the potential of E. dulcis corm for use as a new food source for sufficient nutrients and health benefits by reviewing its nutrients, phytochemicals, functions, processing and food products. Eleocharis dulcis corm contains starches, dietary fibers, non‐starch polysaccharides, proteins, amino acids, phenolics, sterols, puchiin, saponins, minerals and vitamins. Among them, phenolics including flavonoids and quinones could be the major bioconstituents that largely contribute to antioxidant, anti‐inflammatory, antibacterial, antitumor, hepatoprotective, neuroprotective and hypolipidemic functions. Peel wastes of E. dulcis corm tend to be enriched in phenolics to a much higher extent than the edible pulp. Fresh‐cut E. dulcis corm can be consumed as a ready‐to‐eat food or processed into juice for beverage production, and anti‐browning processing is a key to prolonging shelf life. Present food products of E. dulcis corm are centered on various fruit and vegetable beverages, and suffer from single categories and inadequate development. In brief, underutilized E. dulcis corm possesses great potential for use as a new food source for sufficient nutrients and health benefits. © 2021 Society of Chemical Industry.

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Section: Health Benefitsmentioning

confidence: 82%

Eleocharis dulcis corm: phytochemicals, health benefits, processing and food products

Zhang

et al. 2021

J Sci Food Agric

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“…Phenols are organic compounds that contain at least one phenolic group and an aromatic ring attached to a hydroxyl group. Various biological activities, such as antioxidant, antibacterial, and antifungal, have been attributed to these specialized compounds ( Li et al., 2016 ; Liu et al., 2016 ; Dai et al., 2020 ). The antimicrobial activity of phenolic compounds has been related to their ability to denature proteins and modify extracellular pH and hydrophobicity, considering them as surfactants ( Büsra Konuk and Ergüden, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

“…Natural extracts are traditional components in drug development with a special use as natural preservatives that have raised as an alternative for antibiotic treatments. Some of their health-promoting properties are attributed to the presence of compounds with antimicrobial activities ( Wei et al., 2013 ; Dai et al., 2020 ). The use of natural plant-derived antimicrobials can be highly effective in reducing the antibiotic dependence, minimizing the possibility of pathogen resistance to these components, and representing an alternative to cope with this global problem.…”

Section: Introductionmentioning

confidence: 99%

Jacaranda flower (Jacaranda mimosifolia) as an alternative for antioxidant and antimicrobial use

Aguirre‐Becerra

Pineda-Nieto

García‐Trejo

et al. 2020

Heliyon

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Antimicrobial resistance to antibiotics is a serious health problem worldwide, for this reason, the search for natural agents with antimicrobial power against pathogenic microorganisms is of current importance. The objective of this work was to evaluate the antioxidant capacity (ABTS+ and DPPH), antimicrobial activity, and polyphenol compounds of methanolic and aqueous extracts of Jacaranda mimosifolia flowers. The antimicrobial activity against Bacillus cereus ATCC 10876 , Bacillus subtilis ATCC 6633 , Enterococcus faecalis ATCC 51299 , Escherichia coli ATCC 25922 , Listeria monocytogenes ATCC 19115 , Pseudomonas aeruginosa ATCC 27853 , Salmonella typhimurium ATCC 14028, Staphylococcus aureus ATCC 25923, and Streptococcus mutans ATCC 25175, was determined using the Kirby Bauer technique. The results of polyphenolic compounds showed a high amount of total flavonoids in the methanolic and aqueous extracts (503.3 ± 86.5 and 245. 7 ± 27.8 mg Rutin Equivalents/g DW, respectively). Quercetin, gallic acid, caffeic acid, and rutin were identified by the HPLC-DAD technique, while in the GC-MS analysis, esters, fatty acids, organic compounds, as well as monosaccharides were identified. Higher antioxidant capacity was detected by the ABTS technique (94.9% and 62.6%) compared to DPPH values (52.5% and 52.7 %) for methanolic and aqueous extracts, respectively. The methanolic extract showed a greater inhibitory effect on gram-positive bacteria, with a predominant higher inhibition percentage on Listeria monocytogenes and Streptococcus mutans (86% for both). In conclusion, Jacaranda flower extracts could be a natural antimicrobial and antioxidant alternative due to the considerable amount of polyphenolic compounds, and serve as a sustainable alternative for the isolation of active ingredients that could help in agriculture, aquaculture, livestock, pharmaceutics, and other industrial sectors, to remediate problems such as oxidative stress and antimicrobial abuse.

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“…With the progress of science in the modern world and especially since the discovery of penicillin in 1928 by Fleming [ 1 ], it seemed that the use of natural products was no longer an essential need. However, as a result of the antibiotic resistance crisis and the general population seeking natural treatments, research on natural products and notoriously on essential oils is back on the rise [ 2 , 3 , 4 , 5 ]. Essential oils are generally composed of hundreds of secondary metabolites that confer a multitude of biological activities [ 3 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones

et al. 2021

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The increasing bacterial resistance to antibiotics is a worldwide concern. Essential oils are known to possess remarkable antibacterial properties, but their high chemical variability complicates their development into new antibacterial agents. Therefore, the main purpose of this study was to standardize their chemical composition. Several commercial essential oils of ajowan (Trachyspermum ammi L.) and thyme (chemotype thymol) (Thymus vulgaris L.) were bought on the market. GC–MS analysis revealed that thyme essential oils have a chemical composition far more consistent than ajowan essential oils. Sometimes thymol was not even the major compound. The most abundant compounds and the homemade mixtures were tested against two Staphylococcus aureus strains. The antibacterial property of β-caryophyllene presented no direct activity against S. aureus LMG 15975, but in association with thymol or carvacrol at equal percentages an MIC of 125 μg/mL was observed. The mixture of those three compounds at equivalent percentages also decreased by 16-fold the MIC of the penicillin V. Against S. aureus LMG 21674, β-caryophyllene presented an MIC of 31.3 μg/mL and decreased by 267-fold the MIC of the penicillin V. These observations led us to question the benefits of using a complex chemical mixture instead of one active compound to fight bacterial resistance.

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Recent progress of antibacterial natural products: Future antibiotics candidates

Cited by 65 publications

References 173 publications

Eleocharis dulcis corm: phytochemicals, health benefits, processing and food products

Eleocharis dulcis corm: phytochemicals, health benefits, processing and food products

Jacaranda flower (Jacaranda mimosifolia) as an alternative for antioxidant and antimicrobial use

Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones

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