Recent progress of organic fluorescent molecules for bioimaging applications: cancer-relevant biomarkers

Abstract

The work reports the progress of small-fluorescent molecules for bioimaging applications to cancer-relevant biomarkers H+, NO, H2S and reactive oxygen species (H2O2, HClO, O2˙−, 1O2 and ˙OH) over the past six years.

Synthesis, Fluorescence, and Bioactivity of Novel Isatin Derivatives

“…Our group had been focusing on the development of PTP modulators for decades, and developed several fluorescent SHP1 inhibitors as tools to investigate the SHP1 biological function in the complex and dynamic intracellular environment. − Thus, to enrich the diversity of SHP1 fluorescent inhibitor skeletons, all the synthesized isatin compounds were further evaluated against SHP1 PTP by using a broad-spectrum phosphatase inhibitor, NSC87877, as a positive control for SHP1 PTP . Among compounds 3a–3f , compounds with an electron-donor group (−NH 2 , −OMe) and an alkyl group (-methyl, -ethyl, -propyl) on the phenyl ring showed weaker inhibitory activities than the corresponding compound 3a .…”