Recent progress on magnetic nanoparticles for magnetic hyperthermia

Kafrouni, Lina; Savadogo, O.

doi:10.1007/s40204-016-0054-6

Cited by 131 publications

(74 citation statements)

References 97 publications

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“…However, the particle separation by a magnet is not affected. Negligible remanent magnetization and coercivity suggested that IO is a mixture of superparamagnetic and ferrimagnetic particles (>12.5 nm) (Kafrouni and Savadogo, 2016). Saturation magnetization of the IO nanoparticles was lower than that of bulk IO (M s = 76 and 92 A·m 2 /kg for γ-Fe 2 O 3 and Fe 3 O 4 , respectively) (Berkowitz et al, 1968), but sufficient enough to provide excellent manipulation by a magnetic field.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Temperature-Sensitive Solid-Lipid Particles for Targeting and Killing Tumor Cells

et al. 2020

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Magnetic and temperature-sensitive solid lipid particles (mag. SLPs) were prepared in the presence of oleic acid-coated iron oxide (IO-OA) nanoparticles with 1-tetradecanol and poly(ethylene oxide)-block-poly(ε-caprolactone) as lipid and stabilizing surfactant-like agents, respectively. The particles, typically ∼850 nm in hydrodynamic size, showed heat dissipation under the applied alternating magnetic field. Cytotoxic activity of the mag.SLPs, non-magnetic SLPs, and iron oxide nanoparticles was compared concerning the mammalian cancer cell lines and their drug-resistant counterparts using trypan blue exclusion test and MTT assay. The mag.SLPs exhibited dose-dependent cytotoxicity against human leukemia cell lines growing in suspension (Jurkat and HL-60/wt), as well as the doxorubicin (Dox)-and vincristine-resistant HL-60 sublines. The mag.SLPs showed higher cytotoxicity toward drug-resistant sublines as compared to Dox. The human glioblastoma cell line U251 growing in a monolayer culture was also sensitive to mag.SLPs cytotoxicity. Staining of U251 cells with the fluorescent dyes Hoechst 33342 and propidium iodide (PI) revealed that mag.SLPs treatment resulted in an increased number of cells with condensed chromatin and/or fragmented nuclei as well as with blebbing of the plasma membranes. While the Hoechst 33342 staining of cell suggested the pro-apoptotic activity of the particles, the PI staining indicated the pro-necrotic changes in the target cells. These conclusions were confirmed by Western blot analysis of apoptosis-related proteins, study of DNA fragmentation (DNA laddering due to the inter-nucleosomal cleavage and DNA comets due to single strand breaks), as well as by FACS analysis of the patterns of cell cycle distribution (pre-G1 phase) and Annexin V/PI staining of the treated Jurkat cells. The induction of apoptosis or necrosis by the particles used to treat Jurkat cells depended on the dose of the particles. Production of the reactive oxygen species (ROS) was proposed as a potential mechanism of mag.SLPs-induced cytotoxicity. Accordingly, hydrogen peroxide and superoxide radical Ś więtek et al.Magnetic Solid-Lipid Particles levels in mag.SLPs-treated Jurkat leukemic cells were increased by ∼20-40 and ∼70%, respectively. In contrast, the non-magnetic SLPs and neat iron oxides did not influence ROS levels significantly. Thus, the developed mag.SLPs can be used for effective killing of human tumor cells, including drug-resistant ones.

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Section: Discussionmentioning

confidence: 99%

Magnetic Temperature-Sensitive Solid-Lipid Particles for Targeting and Killing Tumor Cells

et al. 2020

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“…In addition, by properly modifying their surface or using them to form magnetically responsive microspheres, the half‐life period could be noticeably elongated. Meanwhile, the uptake by macrophage cells could be greatly reduced and the accurate regional targeting could also be achieved, making the ferromagnetic particles applicable to MRI, target drug delivery, and hyperthermia . Moreover, magnetic levitation and other novel ideas have been put forward, aiming at building 3D cellular patterns in vitro and engineering complicated tissues .…”

Section: Ferrofluid‐based Detection Diagnosis and Therapymentioning

confidence: 99%

“…Meanwhile, the uptake by macrophage cells could be greatly reduced and the accurate regional targeting could also be achieved, making the ferromagnetic particles applicable to MRI, [179,180] target drug delivery, [29,[181][182][183][184] and hyperthermia. [34,185,186] Moreover, magnetic levitation and other novel ideas have been put forward, aiming at building 3D cellular patterns in vitro and engineering complicated tissues. [187][188][189] With these improvements, ferromagnetic particles are believed to be increasingly important in biomedical researches and clinical treatments.…”

Section: Ferrofluid-based Detection Diagnosis and Therapymentioning

confidence: 99%

Flexible Ferrofluids: Design and Applications

et al. 2019

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Ferrofluids, also known as ferromagnetic particle suspensions, are materials with an excellent magnetic response, which have attracted increasing interest in both industrial production and scientific research areas. Because of their outstanding features, such as rapid magnetic reaction, flexible flowability, as well as tunable optical and thermal properties, ferrofluids have found applications in various fields, including material science, physics, chemistry, biology, medicine, and engineering. Here, a comprehensive, in‐depth insight into the diverse applications of ferrofluids from material fabrication, droplet manipulation, and biomedicine to energy and machinery is provided. Design of ferrofluid‐related devices, recent developments, as well as present challenges and future prospects are also outlined.

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“…They include magnetite (Fe 3 O 4 ) and maghemite (γ-Fe 2 O 3 ) nanoparticles [6]. Magnetic nanoparticles play a big role in cancer detection [7][8][9], drug delivery [2,3], as well as hyperthermia treatment [10][11][12]. During the last decade, bi-magnetic core/shell nanoparticles featuring an iron core and an iron oxide (Fe 3 O 4 ) shell have become widely used [13][14][15][16][17][18][19], due to their superior magnetic properties [20,21].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanomaterials for Magnetically-Aided Drug Delivery and Hyperthermia

2019

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Magnetic nanoparticles have continuously gained importance for the purpose of magnetically-aided drug-delivery, magnetofection, and hyperthermia. We have summarized significant experimental approaches, as well as their advantages and disadvantages with respect to future clinical translation. This field is alive and well and promises meaningful contributions to the development of novel cancer therapies.

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Recent progress on magnetic nanoparticles for magnetic hyperthermia

Cited by 131 publications

References 97 publications

Magnetic Temperature-Sensitive Solid-Lipid Particles for Targeting and Killing Tumor Cells

Magnetic Temperature-Sensitive Solid-Lipid Particles for Targeting and Killing Tumor Cells

Flexible Ferrofluids: Design and Applications

Magnetic Nanomaterials for Magnetically-Aided Drug Delivery and Hyperthermia

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