Recent Progress on Mg- and Zn-Based Alloys for Biodegradable Vascular Stent Applications

Abstract

Currently, biodegradable metals for implantation applications are widely investigated to replace biodegradable polymeric implantations, which may cause inflammatory or adverse local tissue reactions. Amongst these metals, magnesium (Mg) and zinc (Zn) alloys with good biocompatibility, mechanical properties, and corrosion resistance are being widely investigated. In this review, the criteria for biodegradable vascular stents, and the advantages and limitations of biodegradable Mg and Zn vascular stents, are summarized and evaluated. By summarizing and discussing recent research on Mg- and Zn-based alloys used as biodegradable vascular stents, this review considered many alloys that can potentially serve as biodegradable vascular stents and suggests future research directions for the development of Mg- and Zn-based alloys as biodegradable metal stents.

A review on magnesium alloys for biomedical applications

“…Mg as a vascular stent is beneficial to regulate heart rhythm, improve blood flow, inhibit platelet activation, and prevent vasoconstriction ( Banjanin and Belojevic, 2018 ). Moreover, Mg-based vascular stent can widen the narrowed arteries and maintain them until the vessel completes remodeling, then gradually degrades and is replaced by neovascular tissue ( Liu et al, 2019b ).…”

Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

“…84,95 Zinc has been alloyed with Mg, Ca, and Sr (and other elements) to create biometals with the objective to tailor the mechanical and degradation properties. 24,95,109,110 For instance, Mg−Zn−Ca alloys (with the nominal composition Mg−4Zn−0.1Ca) were developed with promising values for the tensile strength (380 MPa), endurance limit (120 MPa), and optimal values of low strength. 92 Additionally, studies of quaternary Mg−Ca−Mn−Zn alloys having enhanced corrosion resistance compared to binary Mg−Ca alloys have been reported.…”

“…However, during the corrosion period three layers were formed composed of calcium/phosphorus, zinc oxide, and zinc carbonate; the degradation products were similar to those of the Mg-based alloys. 110 4.4. Memory Alloys.…”

Tailoring of Biodegradable Magnesium Alloy Surface with Schiff Base Coating via Electrostatic Spraying for Better Corrosion Resistance

“…In recent years, Mg alloy has attracted much attention in the field of biomedical materials due to its good biocompatibility and biodegradability, but its poor corrosion resistance is the main limiting factor for its clinical application. The biomedical Mg alloys have a strong tendency of local corrosion in the in vivo environment, which will seriously affect their mechanical properties and cannot give full play to their expected biological functions [8][9][10][11][12][13][14]. The application of a corrosion inhibitor is a common and efficient method to prevent and reduce the corrosion of metal materials.…”