Recent research advances in polysaccharides from Undaria pinnatifida: Isolation, structures, bioactivities, and applications

Zeng, Jiuseng; Luan, Fei; Hu, Jingwen; Liu, Yao; Zhang, Xiumeng; Qin, Tiantian; Zhang, Xia; Liu, Rong; Zeng, Nan

doi:10.1016/j.ijbiomac.2022.02.138

Cited by 31 publications

(15 citation statements)

References 124 publications

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“…14 Undaria pinnatifida (U. pinnatifida) is a brown alga of the class Phaeophyta, order Laminariales, family Alariaceae, and genus Undaria. 15 It is characterized as a temperate annual species, and the general morphology of U. pinnatifida is characterized by a yellowish-brown hue, possessing a smooth texture. It has a prominent thallus structure composed of a substantial algal body, featuring wide and flat fronds.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, several promising novel therapies may offer more effective or safe treatment options for patients with AR 14 . Undaria pinnatifida ( U. pinnatifida ) is a brown alga of the class Phaeophyta, order Laminariales, family Alariaceae, and genus Undaria 15 . It is characterized as a temperate annual species, and the general morphology of U. pinnatifida is characterized by a yellowish‐brown hue, possessing a smooth texture.…”

Section: Introductionmentioning

confidence: 99%

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Undaria pinnatifida ameliorates nasal inflammation by inhibiting eosinophil and mast cell activation and modulating the NF‐κB/MAPKs signaling pathway

Yu,

Fan,

Nguyen

et al. 2024

Immunity Inflam & Disease

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BackgroundAllergic rhinitis (AR) is the most prevalent form of atopic disease. Undaria pinnatifida has potent antioxidative, antidiabetic, and anti‐inflammatory properties.AimsWe investigated the immunomodulatory effect of Undaria pinnatifida extract (UPE) on allergic inflammation in an AR mouse model.Materials & MethodsMice were sensitized and intranasally challenged with ovalbumin (OVA), and the Th1/Th2 and Th17/Treg‐related cytokines and histopathology were exanimated after UPE treatments. Enzyme‐linked immunosorbent assay was performed using serum samples and NALF to detect OVA‐specific immunoglobulins and inflammatory cytokines. Mitogen‐activated protein kinases (MAPKs) were measured by western blotting analysis, and an in vitro study measured mast cell activation induced by compound 48/80.ResultsAfter UPE treatment, nasal and lung allergy symptoms, nasal mucosal swelling, and goblet cell hyperplasia were ameliorated. Oral UPE regulated the balance of Th1/Th2 and Th17/Treg cell differentiation in AR mice in a dose‐dependent manner. In addition, UPE attenuated the migration of eosinophils and mast cells to the nasal mucosa by suppressing nuclear factor kappa B (NF‐κB)/MAPKs. The levels of anti‐OVA IgE and IgG1 were also decreased.DiscussionUPE inhibited inflammation by regulating the NF‐κB/MAPKs signaling pathway and supressing the activation of critical immune cells such as eosinophils and mast cells.ConclusionUPE may have therapeutic potential for AR.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Undaria pinnatifida ameliorates nasal inflammation by inhibiting eosinophil and mast cell activation and modulating the NF‐κB/MAPKs signaling pathway

Yu,

Fan,

Nguyen

et al. 2024

Immunity Inflam & Disease

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“…Undaria pinnatifida is a kind of brown seaweed which has been widely cultivated in Asian countries, including China, Korea, Japan and Indonesia [3]. Traditionally, U. pinnatifida are used as food directly, or as raw materials for the extractions of polysaccharides and proteins [4,5], but the utilization efficiency still remains low [6].…”

Section: Introductionmentioning

confidence: 99%

“…The AOSs produced by alginate lyase had a double bond between C4 and C5 at the non-reducing end, which showed higher biological activities [2]. According to the protein sequence similarity, alginate lyases are distributed in the polysaccharide lyase (PL) families 5,6,7,8,14,15,17,18,31,32,34,36,39 and 41 in the Carbohydrate-Active Enzymes (CAZy) database (http://www.cazy.org/, accessed on 16 March 2022). Recently, cold-active alginate lyases such as TsAly6A from Thalassomonas sp.…”

Section: Introductionmentioning

confidence: 99%

Releasing Bioactive Compounds from Brown Seaweed with Novel Cold-Adapted Alginate Lyase and Alcalase

Jiang

Yan

et al. 2023

Marine Drugs

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Seaweeds are considered to be third-generation renewable biomasses, the comprehensive utilization of which has drawn increasing attention in recent years. A novel cold-active alginate lyase (VfAly7) was identified from Vibrio fortis and biochemically characterized for brown seaweed utilization. The alginate lyase gene was high-level expressed in Pichia pastoris, with an enzyme yield of 560 U/mL and a protein content of 9.8 mg/mL by high-cell density fermentation. The recombinant enzyme was most active at 30 °C and pH 7.5, respectively. VfAly7 was a bifunctional alginate lyase with both poly-guluronate and poly-mannuronate hydrolysis activities. On the basis of VfAly7, a bioconversion strategy for the utilization of brown seaweed (Undaria pinnatifida) was developed. The obtained AOSs showed stronger prebiotic activity towards tested probiotics when compared to that of commercial fructooligosaccharides (FOSs), while the obtained protein hydrolysates displayed strong xanthine oxidase inhibitory activity with IC50 of 3.3 mg/mL. This study provided a novel alginate lyase tool as well as a biotransformation route for the utilization of seaweeds.

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“…Finally, many researchers have reported that Undaria pinnatifida has several beneficial effects, including antioxidant, anti-cancerous, anti-hypercholesterolemia, and antihypertension properties, which may be correlated with the various bioactive compounds contained by it, such as carotenoids, fucoxanthin, fatty acids, and phytosterols (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). Fucoxanthin is a marine carotenoid that is abundant in edible brown algae, contributes over 10% of the estimated total production of natural carotenoids, and shows strong antioxidant, anticancer, antihypertensive, anti-obesity, and anti-inflammatory effects (30)(31)(32)(33)(34)(35)(36)(37).…”

Section: Introductionmentioning

confidence: 99%

Optimization of fucoxanthin extraction obtained from natural by-products from Undaria pinnatifida stem using supercritical CO2 extraction method

et al. 2022

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In the recent years, edible brown seaweed, Undaria pinnatifida, has presented beneficial effects, which may be correlated with this species containing major bioactive compounds, such as carotenoids, fatty acids, and phytosterols. Marine carotenoid fucoxanthin is abundantly present in edible Undaria pinnatifida and features strong bioactive activities. The stem of Undaria pinnatifida is very hard to gnaw off and cannot be swallowed; therefore, it is usually discarded as waste, making it an environmental issue. Hence, making full use of the waste stem of Undaria pinnatifida is an urgent motivation. The present study aims to explore the optimal preparation technology of fucoxanthin from Undaria pinnatifida stems using supercritical carbon dioxide methods and provides approaches for the extraction and preparation of bioactive compounds from a waste seaweed part. With the comprehensive optimization conditions applied in this study, the experimental yield of fucoxanthin agreed closely with the predicted value by > 99.3%. The potential of α-amylase and glucoamylase to inhibit bioactive compounds was evaluated. The results demonstrated that the inhibition activity (IC50 value) of α-amylase (0.1857 ± 0.0198 μg/ml) and glucoamylase (0.1577 ± 0.0186 μg/ml) varied with extraction conditions due to the different contents of bioactive components in the extract, especially fucoxanthin (22.09 ± 0.69 mg/g extract). Therefore, this study confirmed supercritical fluid extraction technology to be a useful sample preparation method, which can effectively be used to prepare fucoxanthin from waste marine resources. This method can potentially be applied in functional food and related industries.

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Recent research advances in polysaccharides from Undaria pinnatifida: Isolation, structures, bioactivities, and applications

Cited by 31 publications

References 124 publications

Undaria pinnatifida ameliorates nasal inflammation by inhibiting eosinophil and mast cell activation and modulating the NF‐κB/MAPKs signaling pathway

Undaria pinnatifida ameliorates nasal inflammation by inhibiting eosinophil and mast cell activation and modulating the NF‐κB/MAPKs signaling pathway

Releasing Bioactive Compounds from Brown Seaweed with Novel Cold-Adapted Alginate Lyase and Alcalase

Optimization of fucoxanthin extraction obtained from natural by-products from Undaria pinnatifida stem using supercritical CO2 extraction method

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