Recent Research in the Field of 5-Hydroxytryptamine and Related Indolealkylamines

Erspamer, V.

doi:10.1007/978-3-0348-7041-2_3

Cited by 58 publications

(32 citation statements)

References 772 publications

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“…In the present study we have examined the effects on 5-HT uptake into synaptosomes from rat hypothalamic homogenates of several molecular modifications of the imipramine molecule. The hypothalamus of the rat brain is known to have a high concentration of 5-HT (Erspamer, 1966).…”

Section: Introductionmentioning

confidence: 99%

Structure‐activity Relations for the Inhibition of 5‐hydroxytryptamine Uptake by Tricyclic Antidepressants Into Synaptosomes From Serotonergic Neurones in Rat Brain Homogenates

Horn

Trace

1974

British J Pharmacology

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The inhibitory effects of various analogues of imipramine on [3H]‐5‐hydroxytryptamine (5‐HT) uptake into homogenates of rat hypothalamus were examined. For structures with a three carbon side chain the tertiary amine derivative was more potent than the compound with a secondary amine function. Potency was reduced by increasing or decreasing the length of the three carbon side chain by one carbon atom. Substitution of a methyl group in the α or β position in the side chain reduced potency. Replacement of the dimethylene bridge in imipramine by a sulphur atom or substitution of a C=C double bond for the exocyclic N‐C bond of imipramine both led to a fall in potency. 3‐Chlorimipramine was the most potent inhibitor of [3H]‐5‐hydroxytryptamine uptake of the compounds tested.

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Section: Introductionmentioning

confidence: 99%

Structure‐activity Relations for the Inhibition of 5‐hydroxytryptamine Uptake by Tricyclic Antidepressants Into Synaptosomes From Serotonergic Neurones in Rat Brain Homogenates

Horn

Trace

1974

British J Pharmacology

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“…Moreover, 5-HT, like histamine, has a widespread distribution in the tissues {Dixon, 1959;Uvnas, 1964;Erspamer, 1966). It is a vasoactive sub stance which, especially in the rat, increases vascular permeability {Spector and Willoughby, 1964).…”

Section: Abstract Histamine 5-hydroxytryptamine (5-ht) Methergoline mentioning

confidence: 99%

Action of 5-Hydroxytryptamine, Histamine and Methergoline on Phagocytosis

Cassone¹,

Fundarò²,

Molinengo³

1974

Pharmacology

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Polymorphonuclear leukocytes of guinea pig were used to study the action of 5-hydroxytryptamine, histamine and methergoline on phagocytosis. Phagocytosis was reduced by 5-HT; this effect was only in part antagonized by histamine: the antagonism was not competitive. Methergoline at concentration higher than 1·10^–6 reduced phagocytosis: this effect was not modified by histamine. At doses lower than 1 10^–6 methergoline competitively antagonized the depression of phagocytosis caused by 5-HT.

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“…With peripheral administration of 5-HT its ubiquitous presence in the body, especially in the digestive tract, should be considered; for example, in the intestine it is synthesized in ribosomes and stored in secretion granules of enterochromaffin cells (N emoto et al 1983). Here more than 90 % of 5-HT contained in the body are localized (Erspamer 1961in Pilot et al 1983). …”

Section: Discussionmentioning

confidence: 99%

Effects of Serotonin on the Food Intake in Chickens in the Early Post-hatching Period

Baranyiová¹

1990

Acta Vet. Brno

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Recent Research in the Field of 5-Hydroxytryptamine and Related Indolealkylamines

Cited by 58 publications

References 772 publications

Structure‐activity Relations for the Inhibition of 5‐hydroxytryptamine Uptake by Tricyclic Antidepressants Into Synaptosomes From Serotonergic Neurones in Rat Brain Homogenates

Structure‐activity Relations for the Inhibition of 5‐hydroxytryptamine Uptake by Tricyclic Antidepressants Into Synaptosomes From Serotonergic Neurones in Rat Brain Homogenates

Action of 5-Hydroxytryptamine, Histamine and Methergoline on Phagocytosis

Effects of Serotonin on the Food Intake in Chickens in the Early Post-hatching Period

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