Recent research progress on polyphosphazene-based drug delivery systems

Ni, Zhipeng; Yu, Haipeng; Wang, Li; Shen, Di; Elshaarani, Tarig; Fahad, Shah; Khan, Amin; Haq, Fazal; Teng, L.

doi:10.1039/c9tb02517k

Cited by 42 publications

(38 citation statements)

References 108 publications

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“…Hence, polyphosphazenes can possess immobilization capabilities and tend to degrade to release the immobilized molecules, which can have therapeutic effects (Figure 2; Ni et al, 2020;Ogueri et al, 2020a;Strasser & Teasdale, 2020).…”

Section: B I Omed I C Al a S Pec Ts And Implic Ationsmentioning

confidence: 99%

“…Among all the practical implications of polyphosphazene technology, their applications in biomedicine may be the most significant contributions to polymer science (Baillargeon & Mequanint, 2014; Ogueri et al, 2019; Ogueri, Jafari, et al, 2019). The biomedical research on polyphosphazenes has garnered relatively considerable interest, especially in bone regenerative engineering and drug delivery (Allcock, 2016; Allcock & Morozowich, 2012; Baillargeon & Mequanint, 2014; Ni et al, 2020; Ogueri et al, 2019). One of the most intriguing parts of macromolecular substitution reaction is its variability that allows the incorporation of several biologically relevant groups onto the skeletal backbone of polyphosphazenes (Ogueri et al, 2020a).…”

Section: Biomedical Aspects and Implicationsmentioning

confidence: 99%

“…One of the most intriguing parts of macromolecular substitution reaction is its variability that allows the incorporation of several biologically relevant groups onto the skeletal backbone of polyphosphazenes (Ogueri et al, 2020a). Hence, polyphosphazenes can possess immobilization capabilities and tend to degrade to release the immobilized molecules, which can have therapeutic effects (Figure 2; Ni et al, 2020; Ogueri et al, 2020a; Strasser & Teasdale, 2020).…”

Section: Biomedical Aspects and Implicationsmentioning

confidence: 99%

“…Also, degradable polyphosphazenes have shown promise in their applications as carriers for the controlled release of bioactive and therapeutic molecules (Ogueri et al, 2020a; Salinas et al, 2020; Strasser & Teasdale, 2020). The process of tissue regeneration and the release of immobilized molecules can be controlled and regulated by modulating the degradation of polyphosphazenes (Ni et al, 2020; Ogueri, Allcock, et al, 2019; Ogueri et al, 2020a). The adjustment of the polyphosphazene materials’ degradation pattern can be managed by using the hydrophilic–lipophilic balance of the substituent groups (Allcock & Morozowich, 2012; Ogueri et al, 2020a).…”

Section: Introductionmentioning

confidence: 99%

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Biomedical applications of polyphosphazenes

Ogueri

Ude

et al. 2020

Med Devices & Sens

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Although numerous conventional organic polymers have been utilized in biomedical applications, a few numbers of them have had expected and desired success for essential medical use such as scaffolding materials for regenerative engineering, controlled drug delivery systems, and surgical sutures (Ogueri, Jafari, Ivirico, & Laurencin, 2019). This is because most organic polymers (with few exceptions) lack the design flexibility and property tunability as materials scientist and engineers often focus on harnessing and optimizing the physicochemical properties of polymers during design, scale-up, and commercialization (Ogueri, Ivirico, Nair, Allcock,

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Section: B I Omed I C Al a S Pec Ts And Implic Ationsmentioning

confidence: 99%

Section: Biomedical Aspects and Implicationsmentioning

confidence: 99%

Section: Biomedical Aspects and Implicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biomedical applications of polyphosphazenes

Ogueri

Ude

et al. 2020

Med Devices & Sens

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“…Their unique macromolecular structure consists of an alternating phosphorus and nitrogen backbone and organic side groups, which provides for hydrolytic degradability under physiological conditions [30] and enables self-assembly with macromolecular drugs, including proteins, and some biological targets through non-covalent interactions [27,[31][32][33][34]. PZ polymers have been formulated mostly as vaccine adjuvants [35] or in supramolecular assemblies including micelles, nanoparticles, hydrogels etc., hence they are flexible systems with multiple applications accorded by adjusting the side groups for different applications [36].…”

Section: Introductionmentioning

confidence: 99%

Intracellular Delivery of Active Proteins by Polyphosphazene Polymers

et al. 2021

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Achieving intracellular delivery of protein therapeutics within cells remains a significant challenge. Although custom formulations are available for some protein therapeutics, the development of non-toxic delivery systems that can incorporate a variety of active protein cargo and maintain their stability, is a topic of great relevance. This study utilized ionic polyphosphazenes (PZ) that can assemble into supramolecular complexes through non-covalent interactions with different types of protein cargo. We tested a PEGylated graft copolymer (PZ-PEG) and a pyrrolidone containing linear derivative (PZ-PYR) for their ability to intracellularly deliver FITC-avidin, a model protein. In endothelial cells, PZ-PYR/protein exhibited both faster internalization and higher uptake levels than PZ-PEG/protein, while in cancer cells both polymers achieved similar uptake levels over time, although the internalization rate was slower for PZ-PYR/protein. Uptake was mediated by endocytosis through multiple mechanisms, PZ-PEG/avidin colocalized more profusely with endo-lysosomes, and PZ-PYR/avidin achieved greater cytosolic delivery. Consequently, a PZ-PYR-delivered anti-F-actin antibody was able to bind to cytosolic actin filaments without needing cell permeabilization. Similarly, a cell-impermeable Bax-BH3 peptide known to induce apoptosis, decreased cell viability when complexed with PZ-PYR, demonstrating endo-lysosomal escape. These biodegradable PZs were non-toxic to cells and represent a promising platform for drug delivery of protein therapeutics.

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Antimicrobial, Antioxidant, and Anti‐Inflammatory Nanoplatform for Effective Management of Infected Wounds

Su,

Chen,

Jing

et al. 2023

Adv Healthcare Materials

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Burn wound healing continues to pose significant challenges due to excessive inflammation, the risk of infection, and impaired tissue regeneration. In this regard, an antibacterial, antioxidant, and anti‐inflammatory nanocomposite (called HPA) that combines a nanosystem using hexachlorocyclotriphosphazene and the natural polyphenol of Phloretin with silver nanoparticles (AgNPs) is developed. HPA effectively disperses AgNPs to mitigate any toxicity caused by aggregation while also showing the pharmacological activities of Phloretin. During the initial stage of wound healing, HPA rapidly releases silver ions from its surface to suppress bacterial activity. Moreover, these nanoparticles are pH‐sensitive and degrade efficiently in the acidic infection microenvironment, gradually releasing Phloretin. This sustained release of Phloretin helps scavenge overexpressed reactive oxygen species in the infected microenvironment area, thus reducing the upregulation of pro‐inflammatory cytokines. The antibacterial activity, free radical clearance, and regulation of inflammatory factors of HPA through in vitro experiments are validated. Additionally, its effects using an infectious burn mouse model in vivo are evaluated. HPA is found to promote collagen deposition and epithelialization in the wound area. With its synergistic antibacterial, antioxidant, and anti‐inflammatory activities, as well as favorable biocompatibilities, HPA shows great promise as a safe and effective multifunctional nanoplatform for burn injury wound dressings.

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Recent research progress on polyphosphazene-based drug delivery systems

Abstract: In recent years, synthetic polymer materials have become a research hotspot in the field of drug delivery. Polyphosphazenes are one of the most promising biomedical materials for the future due to their controllable degradation properties and structural flexibility.

Cited by 42 publications

References 108 publications

Biomedical applications of polyphosphazenes

Biomedical applications of polyphosphazenes

Intracellular Delivery of Active Proteins by Polyphosphazene Polymers

Antimicrobial, Antioxidant, and Anti‐Inflammatory Nanoplatform for Effective Management of Infected Wounds

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