Recent Research Trends on Bismuth Compounds in Cancer Chemoand Radiotherapy

Abstract

The application of coordination chemistry in the light of nanotechnology is a rapidly developing research field in medicine. Bismuth complexes have been widely and willingly used in biomedicine with satisfactory therapeutic effects, mostly in Helicobacter pylori eradication, but also as potential anti-microbial and anti-leishmanial agents. Additionally, in recent years, an application of bismuth-based compounds as potent anticancer drugs has also been studied extensively. Therefore, in this review, we want to highlight a number current problems connected with: (1) characterization of bismuth complexes based on thiosemicarbazone, hydrazone, and dithiocarbamate classes of ligands as potential chemotherapeutics, (2) pioneering research on application of bismuth-based nanoparticles and nanodots for radiosensitization, and (3) research challenges in using bismuth radionuclides in targeted radioimmunotherapy.

Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans

“…Bismuth compounds have been used in medicine for more than two centuries [4]. Bismuth subsalicylate has been utilized to treat diarrhea-related ailments since the 1900s [5], and most recently, bismuth compounds have been used in computed tomography imaging and anti-cancer therapy [6,7]. In the U.S., around 30% of the bismuth compounds are used for cosmetic and pharmaceutical applications [4].…”

Sensing Zn2+ in Aqueous Solution with a Fluorescent Scorpiand Macrocyclic Ligand Decorated with an Anthracene Bearing Tail

“…Scorpiand type aza-macrocyclic ligands, that is aza-macrocyclic ligands with coordinating tails [1], and their metal complexes have attracted considerable interest thanks to the numerous uses they have been tested for, including but not limited to various biomedical applications [2,3] (MRI contrast agents [4,5], radioisotopes complexation and radiolabelling [6][7][8][9], radiotherapy [10][11][12][13][14], chelation therapy [15][16][17], antiproliferative treatments [18][19][20][21], enzyme mimicking [22][23][24][25][26][27][28][29]), catalysis [30][31][32][33][34][35][36] and chemosensing [37][38][39][40][41][42][43].…”

Toxicity, morphological and structural properties of chitosan‐coated Bi 2 O 3 –Bi(OH) 3 nanoparticles prepared via DC arc discharge in liquid: a potential nanoparticle‐based CT contrast agent

“…Besides, instability of bismuth nanoparticles in inorganic liquid mediums like water, leads to shape bismuth oxide. Therefore, bismuth compound nanoparticles usage increased dramatically [12, 25]. In this regard, most studies have been carried out on bismuth sulphide [16, 22].…”