2012
DOI: 10.2174/092986712803414213
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Recent Researches in Triazole Compounds as Medicinal Drugs

Abstract: Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole ring are readily able to bind with a variety of enzymes and receptors in biological system via diverse non-covalent interactions, and thus display versatile biological activities. The related researches in triazole-based derivatives as medicinal drugs have been an extremely active topic, and numerous excellent achievements have been acquired. Noticeably, a large number of triazole compounds as clinical drugs or candidates ha… Show more

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Cited by 517 publications
(110 citation statements)
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“…Refluxing equimolar amounts of N 1 -arylamidrazones 1a-f with diethyl azodicarboxylate (2) in dry EtOH, catalyzed by a few drops of triethylamine, led to the formation of 4-aryl-5-methyl-3-phenyl-1,2,4-triazoles 3a-f in 68-75% yields and 4-aryl-3,5-diphenyl-1,2,4-triazoles 4a-f in 13-20% yields, together with traces of diethyl hydrazine-1,2-dicarboxylate (5) (Scheme 1). The products were separated by preparative TLC; compounds 4 tended to co-elute with additional 5, which was removed by recrystallization.…”
Section: Resultsmentioning
confidence: 99%
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“…Refluxing equimolar amounts of N 1 -arylamidrazones 1a-f with diethyl azodicarboxylate (2) in dry EtOH, catalyzed by a few drops of triethylamine, led to the formation of 4-aryl-5-methyl-3-phenyl-1,2,4-triazoles 3a-f in 68-75% yields and 4-aryl-3,5-diphenyl-1,2,4-triazoles 4a-f in 13-20% yields, together with traces of diethyl hydrazine-1,2-dicarboxylate (5) (Scheme 1). The products were separated by preparative TLC; compounds 4 tended to co-elute with additional 5, which was removed by recrystallization.…”
Section: Resultsmentioning
confidence: 99%
“…Therefore, triazoles display widespread biological activities. Hence, many triazole derivatives serve as medicinal drugs [2]. Triazoles also have antifungal activities [3].…”
Section: Introductionmentioning
confidence: 99%
“…Thus, the incorporation of 1,2,3-triazolyl cores into the scaffolds of bioactive molecules is interesting [16,18].…”
Section: Introductionmentioning
confidence: 99%
“…More and more triazole derivatives, with strong pharmacological activity, low toxicity, less adverse effects, fewer multi-drug resistances, high bioavailability, good pharmacokinetics property and drug-targeting, diversity of drug administration, broad spectrum, better curative effect etc., A large number of triazole compounds as clinical drugs or candidates have been frequently employed for the treatment of various types of diseases, Triazole compounds as medicinal drugs, including antifungal, anticancer, antibacterial, antitubercular, antiviral, anti-inflammatory and analgesic,anticonvulsant, antiparasitic, antidiabetic, anti-obesitic, antihista-minic, anti-neuropathic, antihypertensive as well as other biological activities Wang, 2012 andKhabnadideh et al, 2012). In fact several benzotriazoles have shown potential biological activities such as antimycobacterial (Sanna et al, 2002), antitumor (Handratta et al, 2005) and anti-inflammatory (Dawood et al, 2006) activities.…”
Section: Introductionmentioning
confidence: 99%