Recent results of therapy for scirrhous gastric cancer

Ikeguchi, Masahide; Miyake, Takanori; Matsunaga, Tomoyuki; Yamamoto, Manabu; Fukumoto, Yoshihiro; Yamada, Yosinori; Fukuda, Kenji; Saito, Hiroaki; Tatebe, Shigeru; Tsujitani, Shunichi

doi:10.1007/s00595-008-3860-1

Cited by 44 publications

(50 citation statements)

References 37 publications

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“…LSGC, localized type IV scirrhous gastric cancer; LP, linitis plastica; OGC, other types of advanced gastric cancer. and strong chemotherapy, including S-1, may be a more favorable option than aggressive surgery or palliative gastrectomy (2,3,13,16). In the present study, peritoneal cytology was an independent prognostic factor in SGC.…”

Section: A B C Discussionsupporting

confidence: 47%

“…Despite recent advances in the diagnosis and treatment of gastric cancer, the majority of cases of SGC are not detected at an early stage since tumor cells migrate throughout the submucosa without severely affecting the mucosal lining of the stomach. This causes difficulty in detecting cancer cells by gastrointestinal series or endoscopy (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Biological significance of localized Type IV scirrhous gastric cancer

et al. 2011

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Abstract. The prognosis of type IV scirrhous gastric cancer (SGC) is extremely poor. Linitis plastica (LP), the so-called 'leather bottle stomach', is believed to be a typical case of SGC, which is usually diagnosed as a far-advanced gastric cancer. The pathogenesis of this disease remains unclear. Although typical SGC often invades the entire stomach, atypical cases show SGC localized to one region of the stomach. The aim of the present study was to investigate localized SGC (LSGC) and its biological significance. A total of 509 patients with advanced gastric cancer who underwent gastrectomy were evaluated. These patients were divided into three groups as follows: 19 patients with type IV scirrhous lesions invading the whole stomach (defined as LP), 60 patients with type IV scirrhous lesions localized in less than two thirds of the stomach (defined as LSGC) and the remaining 430 patients with all other types of gastric cancer (OGC), and then clinicopathologically compared. Results showed that LP had deeper invasion (p=0.006), more frequent peritoneal dissemination including positive cytology (p=0.01 and p=0.018) and lower curability (p=0.03) compared with LSGC, whereas LSGC showed a higher malignant potential in a number of clinicopathological factors compared with OGC. Univariate analysis showed that survival in patients with LP was significantly poorer than in those with LSGC (p=0.002) whose survival was, in turn, inferior to those with OGC. By contrast, LSGC was not a prognostic factor in SGC according to the multivariate analysis. The findings of this study suggested that the malignant status of LSGC differs from that of LP, and that curative gastrectomy is effective in improving the outcome for LSGC but not for LP, as LSGC may represent the prelinitis condition. IntroductionType IV scirrhous gastric cancer (SGC) is characterized by diffuse infiltration and proliferation of poorly differentiated gastric cancer cells accompanied by marked stromal fibrosis (1). Linitis plastica (LP), also known as leather bottle stomach, is believed to be a typical case of SGC, usually involving the whole stomach and characterized by a grossly thickened wall. Despite recent advances in the diagnosis and treatment of gastric cancer, the majority of cases of SGC are not detected at an early stage since tumor cells migrate throughout the submucosa without severely affecting the mucosal lining of the stomach. This causes difficulty in detecting cancer cells by gastrointestinal series or endoscopy (2-5).In LP, the cancer is poorly differentiated and originates in the gastric fundic gland area as a small IIc lesion, which shows extensive submucosal invasion without obvious concavities or recesses and a leather bottle-like appearance with giant folded walls. These walls are occasionally accompanied by peritoneal dissemination, considerable lymph node metastasis and direct invasion into the surrounding organs (6-8). Therefore, LP is recognized as a far-advanced gastric cancer in most cases, or as an early cancer that is accidentally ...

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Section: A B C Discussionsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Biological significance of localized Type IV scirrhous gastric cancer

et al. 2011

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“…1b). Scirrhous carcinomas account for about 10% of all gastric carcinomas, and carry a worse prognosis than other types of gastric carcinoma, reflecting their rapid proliferation of cancer cells [3][4][5]. The common features of scirrhous gastric cancer include rapidly progressive invasion, and a high frequency of metastasis to the peritoneum [6].…”

Section: Introductionmentioning

confidence: 99%

Cancer–Stromal Interactions in Scirrhous Gastric Carcinoma

Yashiro

Hirakawa

2010

Cancer Microenvironment

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Fibroblasts play an important role in the progression, growth and spread of gastric cancers. Cancer-stroma interactions have been especially evident in the scirrhous type of gastric carcinoma. Fibroblasts are associated with the cancer progression at the primary and metastatic site. The proliferative and invasive ability of scirrhous gastric cancer cells are closely associated with the growth factors produced by organ-specific fibroblasts. Fibroblasts are therefore a key determinant in the malignant progression of gastric cancer and represent an important target for cancer therapies.

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“…New anti-cancer drugs are being used for advanced and recurrent gastric cancer in many institutions [1]. A recent paper has suggested that neoadjuvant chemotherapy, such as preoperative intraperitoneal chemotherapy (IPC) combined with systemic chemotherapy using S-1 and docetaxel may have a strong survival benefit for patients with scirrhous gastric cancer [2].…”

Section: Introductionmentioning

confidence: 99%

“…However, many questions remain unanswered, such as whether neoadjuvant chemotherapy is better than adjuvant chemotherapy, and whether IPC is better than systemic chemotherapy [2]. Moreover, there is as yet no effective treatment against peritoneal dissemination.…”

Section: Introductionmentioning

confidence: 99%

Comparison between the Gastric Cancer Cell Line MKN-45 and the High-Potential Peritoneal Dissemination Gastric Cancer Cell Line MKN-45P

et al. 2011

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Summary: Peritoneal metastasis is the most common form of recurrence in gastric cancer, and is associated with a poor prognosis. It is clear that many agents are involved at the various stages of this process, however, many aspects of the progression remain unclear. In the present study we compared the gastric cancer cell line MKN-45 with the high-potential peritoneal dissemination gastric cancer cell line MKN-45P, established from MKN-45. The supernatant of culture medium of MKN-45 cells or MKN-45P cells was collected, and the concentrations of interleukin-1β (IL-1β), IL-6, IL-8, hepatocyte growth factor (HGF), Transforming growth factor beta-β1 (TGF-β1), vascular endothelial growth factor (VEGF), matrix metalloproteinase-2 (MMP-2), MMP-9, and tissue inhibitor of metalloproteinase-1 (TIMP-1) proteins were measured using an enzyme-linked immuno sorbent assay (ELISA) method. Invasion, wound healing and adhesion assays were performed in vitro to examine interstitial invasion, migration and adhesion in the gastric cancer cell lines. Moreover, Western blotting was performed to determine the expression of cyclooxygenase-1 (COX-1) and COX-2 proteins in the culture media of the cell lines. The concentrations of IL-6, IL-8, VEGF and MMP-2 protein in the culture supernatant of MKN-45P were significantly higher than those of MKN-45. Percent adhesion of MKN-45P was significantly higher than that of MKN-45 in the fibronectin-coated group. There was no significant difference in invasion or migration between MKN-45 and MKN-45P. COX-1 and COX-2 proteins were observed in both cell lines. These results suggested that secretion of IL-6, IL-8, VEGF and MMP-2 from cancer cells, and adhesion of cancer cells to fibronectin, were related to the establishment of peritoneal dissemination.

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Recent results of therapy for scirrhous gastric cancer

Cited by 44 publications

References 37 publications

Biological significance of localized Type IV scirrhous gastric cancer

Biological significance of localized Type IV scirrhous gastric cancer

Cancer–Stromal Interactions in Scirrhous Gastric Carcinoma

Comparison between the Gastric Cancer Cell Line MKN-45 and the High-Potential Peritoneal Dissemination Gastric Cancer Cell Line MKN-45P

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