Recent status of sesaminol and its glucosides: Synthesis, metabolism, and biological activities

Li, Qizhang; Zuo, Zan-Wen; Liu, Yan

doi:10.1080/10408398.2022.2098248

Cited by 4 publications

(1 citation statement)

References 143 publications

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“…These lignans were reported to exhibit antioxidant and anticancer activities, neuroprotective properties, cholesterol-reducing effects, and anti-osteoarthritis [16][17][18][19][20][21][22][23]. Other derivatives of sesame (i.e., sesaminol, sesamolinol, and sesamol) were also found to possess pharmacological properties (e.g., anti-inflammatory, antioxidant, anti-aging, and anti-hepatotoxic activities), albeit small amounts [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Sesamin: A Promising Therapeutic Agent for Ameliorating Symptoms of Diabetes

Huang,

Chuang,

Rejano

et al. 2023

Molecules

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Diabetes is a chronic metabolic disease characterized by improperly regulating proteins, carbohydrates, and lipids due to insulin deficiency or resistance. The increasing prevalence of diabetes poses a tremendous socioeconomic burden worldwide, resulting in the rise of many studies on Chinese herbal medicines to discover the most effective cure for diabetes. Sesame seeds are among these Chinese herbal medicines that were found to contain various pharmacological activities, including antioxidant and anti-inflammatory properties, lowering cholesterol, improving liver function, blood pressure and sugar lowering, regulating lipid synthesis, and anticancer activities. These medicinal benefits are attributed to sesamin, which is the main lignan found in sesame seeds and oil. In this study, Wistar rat models were induced with type 2 diabetes using streptozotocin (STZ) and nicotinamide, and the effect of sesamin on the changes in body weight, blood sugar level, glycosylated hemoglobin (HbA1c), insulin levels, and the states of the pancreas and liver of the rats were evaluated. The results indicate a reduced blood glucose level, HbA1c, TG, and ALT and AST enzymes after sesamin treatment, while increased insulin level, SOD, CAT, and GPx activities were also observed. These findings prove sesamin’s efficacy in ameliorating the symptoms of diabetes through its potent pharmacological activities.

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