Recent Survey of Effective Doses of F-18 FDG Torso PET/CT in Korea and the Current Recommendations for CT Protocols of PET/CT

Chong, Ari; Park, Jung Mi; Pak, Kyoungjune; Kim, Yong-il; Kwon, Hyun Woo; Lee, Eun Seong; Nam, Ki Pyo; Lee, Ho‐Young; Lee, Hong Jae; Yoo, Ik Dong; Eo, Jae Seon; Kim, Ji Young; Yoon, Joon-Kee; Kim, Kyeong Min; Kim, Sang Woo; Kim, Taesung

doi:10.1007/s13139-020-00654-7

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Regarding the risks associated with the 18 F-FDG PET, recent multi-institutional research in Korea revealed that the effective radiation dose from a whole-body 18 F-FDG PET scan for a 70 kg adult is 10.93 ± 3.14 mSv. 42 Furthermore, this dose for 18 F-FDG PET scans that only image the brain is reduced, as compared to torso PET, resulting in an even lower effective radiation dose. The American Association of Physicists in Medicine has stated that the radiation exposure level from a single medical imaging procedure is considered very low or negligible if it is below 50 mSv.…”

Section: Discussionmentioning

confidence: 99%

The Usefulness of ¹⁸F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis

Na,

Kang,

Kim

et al. 2024

Dement Neurocogn Disord

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Background and Purpose Dementia subtypes, including Alzheimer’s dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of 18 F-Fluorodeoxyglucose Positron Emission Tomography ( 18 F-FDG PET) in differentiating these subtypes for precise treatment and management. Methods A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was conducted using databases like PubMed and Embase to identify studies on the diagnostic utility of 18 F-FDG PET in dementia. The search included studies up to November 16, 2022, focusing on peer-reviewed journals and applying the gold-standard clinical diagnosis for dementia subtypes. Results From 12,815 articles, 14 were selected for final analysis. For AD versus FTD, the sensitivity was 0.96 (95% confidence interval [CI], 0.88–0.98) and specificity was 0.84 (95% CI, 0.70–0.92). In the case of AD versus DLB, 18F-FDG PET showed a sensitivity of 0.93 (95% CI 0.88-0.98) and specificity of 0.92 (95% CI, 0.70–0.92). Lastly, when differentiating AD from non-AD dementias, the sensitivity was 0.86 (95% CI, 0.80–0.91) and the specificity was 0.88 (95% CI, 0.80–0.91). The studies mostly used case-control designs with visual and quantitative assessments. Conclusions 18 F-FDG PET exhibits high sensitivity and specificity in differentiating dementia subtypes, particularly AD, FTD, and DLB. This method, while not a standalone diagnostic tool, significantly enhances diagnostic accuracy in uncertain cases, complementing clinical assessments and structural imaging.

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Section: Discussionmentioning

confidence: 99%

The Usefulness of ¹⁸F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis

Na,

Kang,

Kim

et al. 2024

Dement Neurocogn Disord

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“…Moreover, the CT effective dose accounted for more than 43% of the total effective dose. Therefore, the promotion of programs able to reduce CT dose and the personalization of FDG injected dose should be the goals for decreasing unnecessary radiation exposure [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Algorithm for Reducing Overall Biological Detriment Caused by PET/CT: an Age-Based Study

Spadafora¹,

Sannino²,

Mansi

et al. 2023

Nucl Med Mol Imaging

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Purpose This study is to use a simple algorithm based on patient’s age to reduce the overall biological detriment associated with PET/CT. Materials and Methods A total of 421 consecutive patients (mean age 64 ± 14 years) undergoing PET for various clinical indications were enrolled. For each scan, effective dose (ED in mSv) and additional cancer risk (ACR) were computed both in a reference condition (REF) and after applying an original algorithm (ALGO). The ALGO modified the mean dose of FDG and the PET scan time parameters; indeed, a lower dose and a longer scan time were reported in the younger, while a higher dose and a shorter scan time in the older patients. Moreover, patients were classified by age bracket (18–29, 30–60, and 61–90 years). Results The ED was 4.57 ± 0.92 mSv in the REF condition. The ACR were 0.020 ± 0.016 and 0.0187 ± 0.013, respectively, in REF and ALGO. The ACR for the REF and ALGO conditions were significantly reduced in males and females, although it was more evident in the latter gender (all p < 0.0001). Finally, the ACR significantly reduced from the REF condition to ALGO in all three age brackets (all p < 0.0001). Conclusion Implementation of ALGO protocols in PET can reduce the overall ACR, mainly in young and female patients.

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A new upper limit for effective dose in patient administered with 18F-FDG for PET/CT whole-body imaging with diagnostic CT parameters

Velo¹,

Ismail²,

Mohandas³

et al. 2023

Journal of Medical Imaging and Radiation Sciences

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Recent Survey of Effective Doses of F-18 FDG Torso PET/CT in Korea and the Current Recommendations for CT Protocols of PET/CT

Cited by 4 publications

References 15 publications

The Usefulness of ¹⁸F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis

The Usefulness of ¹⁸F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis

Algorithm for Reducing Overall Biological Detriment Caused by PET/CT: an Age-Based Study

A new upper limit for effective dose in patient administered with 18F-FDG for PET/CT whole-body imaging with diagnostic CT parameters

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Recent Survey of Effective Doses of F-18 FDG Torso PET/CT in Korea and the Current Recommendations for CT Protocols of PET/CT

Cited by 4 publications

References 15 publications

The Usefulness of 18F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis

The Usefulness of 18F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis

Algorithm for Reducing Overall Biological Detriment Caused by PET/CT: an Age-Based Study

A new upper limit for effective dose in patient administered with 18F-FDG for PET/CT whole-body imaging with diagnostic CT parameters

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Product

Resources

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The Usefulness of ¹⁸F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis

The Usefulness of ¹⁸F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis