Recent theranostic applications of hydrogen peroxide-responsive nanomaterials for multiple diseases

Huang, Linjie; Su, Yina; Zhang, Dongdong; Zeng, Zheng; Hu, Xueqi; Hong, Shanni; Lin, Xiahui

doi:10.1039/d3ra05020c

Cited by 6 publications

(1 citation statement)

References 247 publications

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“…180 Recent research proposed that epidermal regeneration and bone reconstruction may have different design requirements. 181–184 For H 2 O 2 -supplying materials, the antitumor capacity was a non-specific effect that may injure the healthy cells. 185 Tissue regeneration raised a high request for these problems.…”

Section: Application Of H2o2-supplying Materials For Tumor Therapymentioning

confidence: 99%

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Zhang,

Li,

Tang

et al. 2024

Biomater. Sci.

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Section: Application Of H2o2-supplying Materials For Tumor Therapymentioning

confidence: 99%

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Zhang,

Li,

Tang

et al. 2024

Biomater. Sci.

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One‐Pot Synthesis of Nanoflower‐Like Zn₂SnS₄ as Nanozymes for Highly Sensitive Electrochemical Detection of H₂O₂ Released by Living Cells

Wen,

Ni,

Zeng

et al. 2024

Chemistry A European J

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The sensitive and reliable nanozyme‐based sensor enables the detection of low concentrations of H2O2 in biological microenvironments, it has potential applications as an in‐situ monitoring platform for cellular H2O2 release. The uniformly dispersed bimetallic sulfide (Zn2SnS4) nanoflowers were synthesized via a one‐pot hydrothermal method and the two kinds of metal ions can serve as morphology and structure directing agents for each other in the synthetic process. The nanoparticles were utilized as nanozyme materials to fabricate a novel electrochemical sensor, and it exhibits a distinct electrochemical response towards H2O2 with excellent stability and detection capability (with a minimum detection limit of 1.79 nM (S/N = 3)), the excellent characteristics facilitate the precise detection of low concentrations of H2O2 in biological microenvironments. Use the macrophages differentiated from leukemia THP‐1 cells as a representative sensing model, the sensor was successfully utilized for real‐time monitoring of the release of H2O2 induced by living cells, which has significant potential applications in clinical diagnosis and cancer treatment.

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Biochemical Signal‐Induced Supramolecular Hydrogelation for Structured Free‐Standing Soft Material Formation

Bharathidasan,

Salvi,

Bose

et al. 2024

Macromolecular Bioscience

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Cells coordinate their activity and regulate biological processes in response to chemical signals. Mimicking natural processes, control over the formation of artificial supramolecular materials is of high interest for their application in biology and medicine. Supramolecular material that can form in response to chemical signals is important for the development of autonomously responsive materials. Herein, a supramolecular hydrogel system is reported enabling in situ generation of hydrogelators in response to a specific chemical signal. Using self‐immolative chemistry, spatial control over the formation of supramolecular hydrogel material and structured free‐standing hydrogel objects via providing H2O2 locally is demonstrated. In addition, a hybrid system is developed enabling in situ generation of the H2O2 by the action of an enzyme and glucose, providing an extra handle for the development of an intelligent soft material. This generic design should enable the use of various (chemical)stimuli that can be obtained via coupling different stimuli and various chemical and/or biological markers and appears a versatile approach for the design of smart artificial soft materials that can find application in theranostic purposes.

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Recent theranostic applications of hydrogen peroxide-responsive nanomaterials for multiple diseases

Abstract: To better understand the functions and mechanisms of H2O2-responsive nanomaterials, key examples of their diagnosis and therapy strategies are introduced.

Cited by 6 publications

References 247 publications

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

One‐Pot Synthesis of Nanoflower‐Like Zn₂SnS₄ as Nanozymes for Highly Sensitive Electrochemical Detection of H₂O₂ Released by Living Cells

Biochemical Signal‐Induced Supramolecular Hydrogelation for Structured Free‐Standing Soft Material Formation

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Recent theranostic applications of hydrogen peroxide-responsive nanomaterials for multiple diseases

Abstract: To better understand the functions and mechanisms of H2O2-responsive nanomaterials, key examples of their diagnosis and therapy strategies are introduced.

Cited by 6 publications

References 247 publications

Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

One‐Pot Synthesis of Nanoflower‐Like Zn2SnS4 as Nanozymes for Highly Sensitive Electrochemical Detection of H2O2 Released by Living Cells

Biochemical Signal‐Induced Supramolecular Hydrogelation for Structured Free‐Standing Soft Material Formation

Contact Info

Product

Resources

About

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

One‐Pot Synthesis of Nanoflower‐Like Zn₂SnS₄ as Nanozymes for Highly Sensitive Electrochemical Detection of H₂O₂ Released by Living Cells