Recent Tobacco Smoking is Associated with Poor HIV Medical Outcomes Among HIV-Infected Individuals in New York

Hile, Stephen J.; Feldman, Matthew B.; Alexy, Emily; Irvine, Mary K.

doi:10.1007/s10461-015-1273-x

Cited by 55 publications

(37 citation statements)

References 47 publications

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“…Among PLWH, smoking is associated with increased risk for bacterial pneumonia, chronic obstructive pulmonary disease, CHD and its associated complications, and decreased bone mineral density (Cooperman, ; Lifson et al., ). Although evidence is mixed (Kabali et al., ; Marshall et al., ), smoking may also be associated with HIV disease progression (Hile et al., ). Smoking is more strongly associated with poor health outcomes among PLWH than among those without HIV (Crothers et al., , ) and is likely an important contributor to the substantial comorbidity experienced by PLWH (Marshall et al., ).…”

Section: Other Substance Usementioning

confidence: 99%

Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions

Williams

Hahn

Saitz

et al. 2016

Alcoholism Clin & Exp Res

237

201

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Alcohol use is common among people living with human immunodeficiency virus (HIV). In this narrative review, we describe literature regarding alcohol’s impact on transmission, care, co-infections and comorbidities that are common among people living with HIV (PLWH), as well as literature regarding interventions to address alcohol use and its influences among PLWH. This narrative review identifies alcohol use as a risk factor for HIV transmission, as well as a factor impacting the clinical manifestations and management of HIV. Alcohol use appears to have additive and potentially synergistic effects on common HIV-related comorbidities. We find that interventions to modify drinking and improve HIV-related risks and outcomes have had limited success to date, and we recommend research in several areas. Consistent with Office of AIDS Research/National Institutes of Health priorities, we suggest research to better understand how and at what levels alcohol influences comorbid conditions among PLWH, to elucidate the mechanisms by which alcohol use is impacting comorbidities, and to understand whether decreases in alcohol use improve HIV-relevant outcomes. This should include studies regarding whether state-of-the-art medications used to treat common co-infections are safe for PLWH who drink alcohol. We recommend that future research among PLWH include validated self-report measures of alcohol use and/or biological measurements, ideally both. Additionally, subgroup variation in associations should be identified to ensure that the risks of particularly vulnerable populations are understood. This body of research should serve as a foundation for a next generation of intervention studies to address alcohol use from transmission to treatment of HIV. Intervention studies should inform implementation efforts to improve provision of alcohol-related interventions and treatments for PLWH in healthcare settings. By making further progress on understanding how alcohol use affects PLWH in the era of HIV as a chronic condition, this research should inform how we can mitigate transmission, achieve viral suppression, avoid exacerbating common comorbidities of HIV and alcohol use and make progress toward the 90-90-90 goals for engagement in the HIV treatment cascade.

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Section: Other Substance Usementioning

confidence: 99%

Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions

Williams

Hahn

Saitz

et al. 2016

Alcoholism Clin & Exp Res

237

201

View full text Add to dashboard Cite

show abstract

“…Tobacco-related illnesses, including cardiovascular disease and cancer, are now the leading causes of non HIV-related deaths among PLHIV [4, 5]. Cigarette smoking also places PLHIV at increased risk of unsuppressed viral load, low CD4 count, serious HIV-related co-morbidities and premature death [6, 7]. Despite the overwhelming burden of tobacco use, there is a lack of research demonstrating efficacious approaches to treating nicotine dependence in this population [8].…”

Section: Introductionmentioning

confidence: 99%

Combining Text Messaging and Telephone Counseling to Increase Varenicline Adherence and Smoking Abstinence Among Cigarette Smokers Living with HIV: A Randomized Controlled Study

et al. 2016

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Smoking represents an important health risk for people living with HIV (PLHIV). Low adherence to smoking cessation pharmacotherapy may limit treatment effectiveness. In this study, 158 participants recruited from three HIV care centers in New York City were randomized to receive 12-weeks of varenicline (Chantix) either alone as standard care (SC) or in combination with text message (TM) support or TM plus cell phone-delivered adherence-focused motivational and behavioral therapy (ABT). Generalized linear mixed-effect models found a significant decline in varenicline adherence from week 1–12 across treatment groups. At 12-weeks, the probability of smoking abstinence was significantly higher in SC+TM+ABT than in SC. The study demonstrates the feasibility of delivering adherence-focused interventions to PLHIV who smoke. Findings suggest intensive behavioral support is an important component of an effective smoking cessation intervention for this population, and a focus on improving adherence self-efficacy may lead to more consistent adherence and higher smoking abstinence.

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“…Tobacco use is known to be disproportionately high among PLHIV [17,18], such that advancements in anti-retroviral therapy have unfortunately been met with smoking as a significant contributor to early mortality [19] and non-AIDS-defining cancer mortality [20]. In a study of over 14,000 PLHIV in New York City, smokers were more likely to have unsuppressed viral load and low CD4 cell counts (<200 cells/mm) compared to non-smokers [21]. …”

Section: Introductionmentioning

confidence: 99%

Smoking Predicts Food Insecurity Severity among Persons Living with HIV

et al. 2018

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Food insecurity is a key social and health issue among persons living with HIV (PLHIV). Food insecurity oftentimes co-occurs with substance use, but little is known about the relationship between tobacco use and food insecurity particularly among PLHIV. In this study, we prospectively examined the association of cigarette smoking with food insecurity in a cohort of 108 individuals seeking vocational rehabilitation services. Over the 12-month study period, smokers at baseline reported consistently higher levels of food insecurity compared to non-smokers. Smoking remained an independent risk factor for greater food insecurity, controlling for sociodemographic characteristics and known confounders (e.g., substance use, depression). Food insecurity is a key structural and socioeconomic barrier that may partially explain HIV-related health disparities observed among smokers. Further research is needed to characterize the bio-behavioral mechanisms linking smoking and food insecurity as well as test whether smoking cessation can reduce food insecurity in PLHIV who smoke.

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Recent Tobacco Smoking is Associated with Poor HIV Medical Outcomes Among HIV-Infected Individuals in New York

Cited by 55 publications

References 47 publications

Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions

Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions

Combining Text Messaging and Telephone Counseling to Increase Varenicline Adherence and Smoking Abstinence Among Cigarette Smokers Living with HIV: A Randomized Controlled Study

Smoking Predicts Food Insecurity Severity among Persons Living with HIV

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