Recent trends and impact of localized surface plasmon resonance (LSPR) and surface-enhanced Raman spectroscopy (SERS) in modern analysis

Nanda, Bibhu Prasad; Rani, Priyanka; Paul, Priyanka; Aman,; Ganti, Subrahmanya S.; Bhatia, Rohit

doi:10.1016/j.jpha.2024.02.013

Cited by 20 publications

(2 citation statements)

References 129 publications

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“…[70] FO rival the sensitivity, specificity, and accuracy of prism-based SPR sensors with the advantages of low cost and small size necessary to develop POC tools. [133][134][135] When the light enters the center of the FO and propagates, the F I G U R E 6 (a) Magnetic bead-based dual aptamer fluorescence sandwich analysis. [35] Copyright 2024, Elsevier.…”

Section: Fo Probementioning

confidence: 99%

Biosensing materials for monoclonal antibody detection: An overview

Zhang,

Fan,

Chai

et al. 2024

Responsive Materials

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Considering the continuous advances in the synthesis and clinical applications of monoclonal antibodies (mAbs), precision therapies that employ mAbs are essential. In recent years, extensive efforts have been invested in developing novel strategies or technologies for detection of mAbs. Given the availability of advanced biosensing materials, various assemblies of multifunctional materials can be prepared by intelligent design when evaluating targets for mAbs. This article provides an overview of the recent advances and functional applications of biosensing materials for mAb detection. Subsequently, we present the approaches by which mAb receptors are combined with materials to construct stimulus‐responsive analytical platforms that evaluate the contents and activities of mAbs in biological systems, enabling real‐time monitoring and diagnosis that could facilitate administration of mAbs during treatment. Furthermore, the review examines various applications of biosensing for mAb detection and implications in real‐world contexts; it also discusses ongoing challenges and future prospects.

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Section: Fo Probementioning

confidence: 99%

Biosensing materials for monoclonal antibody detection: An overview

Zhang,

Fan,

Chai

et al. 2024

Responsive Materials

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“…The fluorophore labeling and the specific interaction of biological molecules may influence the actual distance and affect the accuracy of the sensors. LSPR and SERS methods are very sensitive, but they come with a more complex construction pathway [84]. The integration of fiber optic probes and fluorescence chips with the method mentioned above would significantly enhance the accuracy of AFP detection.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma

Ramachandran,

Abul Rub,

Hajja

et al. 2024

Biosensors

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Hepatocellular carcinoma (HCC) is currently one of the most prevalent cancers worldwide. Associated risk factors include, but are not limited to, cirrhosis and underlying liver diseases, including chronic hepatitis B or C infections, excessive alcohol consumption, nonalcoholic fatty liver disease (NAFLD), and exposure to chemical carcinogens. It is crucial to detect this disease early on before it metastasizes to adjoining parts of the body, worsening the prognosis. Serum biomarkers have proven to be a more accurate diagnostic tool compared to imaging. Among various markers such as nucleic acids, circulating genetic material, proteins, enzymes, and other metabolites, alpha-fetoprotein (AFP) is a protein marker primarily used to diagnose HCC. However, current methods need a large sample and carry a high cost, among other challenges, which can be improved using biosensing technology. Early and accurate detection of AFP can prevent severe progression of the disease and ensure better management of HCC patients. This review sheds light on HCC development in the human body. Afterward, we outline various types of biosensors (optical, electrochemical, and mass-based), as well as the most relevant studies of biosensing modalities for non-invasive monitoring of AFP. The review also explains these sensing platforms, detection substrates, surface modification agents, and fluorescent probes used to develop such biosensors. Finally, the challenges and future trends in routine clinical analysis are discussed to motivate further developments.

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