Recent trends in acute myocardial infarction among the young

Wu, Winona; Berman, Aaron D.; Biery, David; Blankstein, Ron

doi:10.1097/hco.0000000000000781

Cited by 38 publications

(27 citation statements)

References 43 publications

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“…However, some populations experience this disease prematurely [ 2 ]. In the last few decades, different studies have shown an increased incidence of CAD in very young people [ 3 , 4 , 5 ], mainly in Asian populations [ 6 ]. Even though they are relatively few in number, these young patients with CAD represent a significant economic and health care burden for society, thus becoming chronic patients [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up

Juan-Salvadores

Díaz

Carreño

et al. 2022

JCDD

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Coronary artery disease (CAD) is a common chronic condition in the elderly. However, the earlier CAD begins, the stronger its impact on lifestyle and costs of health and social care. The present study analyzes clinical and angiographic features and the outcome of very young patients undergoing coronary angiography due to suspected CAD, including a nested case-control study of ≤40-year-old patients referred for coronary angiography. Patients were divided into two groups: cases with significant angiographic stenosis, and controls with non-significant stenosis. Of the 19,321 coronary angiographies performed in our center in a period of 10 years, 504 (2.6%) were in patients ≤40 years. The most common cardiovascular risk factors for significant CAD were smoking (OR 2.96; 95% CI 1.65–5.37), dyslipidemia (OR 2.18; 95% CI 1.27–3.82), and family history of CAD (OR 1.95; 95% CI 1.05–3.75). The incidence of major adverse cardiovascular events (MACE) at follow-up was significantly higher in the cases compared to controls (HR 2.71; 95% CI 1.44–5.11). Three conventional coronary risk factors were directly related to the early signs of CAD. MACE in the long-term follow-up is associated to dyslipidaemia and hypertriglyceridemia. Focusing efforts for the adequate control of CAD in young patients is a priority given the high socio-medical cost that this disease entails to society.

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Section: Introductionmentioning

confidence: 99%

Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up

Juan-Salvadores

Díaz

Carreño

et al. 2022

JCDD

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“…Several unconventional risk factors such as lipoprotein (a), inflammation, and genetic variations were also found, which may also explain some of the reasons for the early occurrence of MI. 19,20 Our data showed that almost 40% of patients<50 years with a high level of LDL-C over 120mg/dl. Besides, nearly half of these young adults with coronary heart disease are obese.…”

Section: Dovepressmentioning

confidence: 73%

Acute Myocardial Infarction in Young Men Under 50 Years of Age: Clinical Characteristics, Treatment, and Long-Term Prognosis

Gao¹,

Wang²,

Shen³

et al. 2021

IJGM

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The prevalence of acute myocardial infarction (AMI) is increasing in young adults, especially in men. This study aims to compare the characteristics and explore the association between age and clinical outcomes in male adults who first experienced AMI. Methods: A total of 2737 male patients with AMI were divided into three groups by age: <50, 50-65, and ≥65 years. Clinical characteristics and long-term results (all-cause and cardiac deaths, nonfatal MI, revascularization, nonfatal stroke, cardiac rehospitalization) were identified across different age subgroups. The association between age and the outcomes was assessed by Cox proportional hazard models. Results: This population was followed up for a median of 36.7 months. Patients <50 years had a lower prevalence of diabetes (19.4%) and previous stroke (1.8%), while they were more often to be smokers (77.1%), obese (26%), dyslipidemia (74.7%), and with the singlevessel disease (16.2%). The risk of cardiovascular and all-cause death in patients ≥65 years was higher than patients <50 years, which was noticed through competing risk regression analysis after adjusting for confounding factors (adjusted HR 3.24; 95% CI 2.26-4.22, p=0.020 for cardiovascular death, adjusted HR 4.17; 95% CI 1.91-9.10, p<0.001 for allcause death). Conclusion:In conclusion, although men who suffered from first AMI under the age of 50 had lower mortality, they had a higher burden of modifiable traditional risk factors. The management of modifiable lifestyles should be addressed to all young AMI patients.

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“…In our study, the mean age of admitted NSTEMI patients was 37.34 ± 6.19 years and among them male predominance was prevalent (72.8%, N = 234). Multiple studies have confirmed male as a risk factor of coronary artery disease hence the increased burden of males diagnosed with NSTEMI is already well established 13,14 and is attributed to the protective effects of estrogens in preventing atherosclerosis and prevalence of smoking which was much more common amongst male that has been clearly demonstrated in various epidemiological studies. Although, mean age of these patients are quite younger as most of the studies have documented STEMI in young population rather than NSTEMI that is why data on young population admitted with NSTEMI is limited.…”

Section: Discussionmentioning

confidence: 94%

Frequency of Cardiogenic Shock in Patients Presenting With Nstemi and Younger Than 45 Years of Age

Kazi

Nazia

et al. 2021

Pak Heart J

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Objective: The objective of this study was to assess the frequency of cardiogenic shock in patients of younger than 45 years of age presenting with NSTEMI. Methodology: A hospital based Cross sectional study has been conducted in a tertiary hospital of Isra University Hospital, Hyderabad in the Department of Cardiology. This study was started in September 2017 and completed on March 2019 and recruited a total of 321 patients NSTEMI patients having age less than 45 years of either gender to determine the burden of cardiogenic shock during hospitalization. Baseline and clinical data were recorded in a pre-structured questionnaire and analyzed using Statistical Package for the Social Sciences (SPSS) version 21.0. Results: Out of total 321 patients the mean age of admitted NSTEMI patients was 37.34 ± 6.19 years and among them male predominance was prevalent (72.8%, N = 234). The overall burden of cardiogenic shock in our study subjects was 19(5.9%). Male gender, cigarette smoking, diabetes mellitus, chronic kidney disease, and increased mean duration of hospital stay were significantly associated with cardiogenic shock in patients admitted with NSTEMI as compared to patients admitted without cardiogenic shock (p<0.05). Conclusion: Our study shows that overall burden of cardiogenic shock is higher in patients with younger age group when they are diabetic, had underlying chronic kidney disease, and increased duration of hospital stay.

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Recent trends in acute myocardial infarction among the young

Cited by 38 publications

References 43 publications

Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up

Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up

Acute Myocardial Infarction in Young Men Under 50 Years of Age: Clinical Characteristics, Treatment, and Long-Term Prognosis

Frequency of Cardiogenic Shock in Patients Presenting With Nstemi and Younger Than 45 Years of Age

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