Recent Trends in Biomimetic NADH Regeneration

Quinto, Tommaso; Köhler, Valentin; Ward, Thomas R.

doi:10.1007/s11244-013-0187-y

Cited by 85 publications

(73 citation statements)

References 55 publications

(67 reference statements)

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“…Glassy‐carbon working and counter electrodes were used along with a Ag/AgCl reference electrode. At a scan rate of 100 mV s −1 , the cyclic voltammograms of the compounds exhibited a reduction signal at −1.1 to −1.6 V (Figure S21), which is characteristic of reduction of the nicotinamide moiety …”

Section: Resultsmentioning

confidence: 99%

Synthesis and Biochemical Evaluation of Nicotinamide Derivatives as NADH Analogue Coenzymes in Ene Reductase

et al. 2019

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Nicotinamide and pyridine‐containing conjugates have attracted a lot of attention in research as they have found use in a wide range of applications including as redox flow batteries and calcium channel blockers, in biocatalysis, and in metabolism. The interesting redox character of the compounds’ pyridine/dihydropyridine system allows them to possess very similar characteristics to the natural chiral redox agents NAD+/NADH, even mimicking their functions. There has been considerable interest in designing and synthesizing NAD+/NADH mimetics with similar redox properties. In this research, three nicotinamide conjugates were designed, synthesized, and characterized. Molecular structures obtained through X‐ray crystallography were obtained for two of the conjugates, thereby providing more detail on the bonding and structure of the compounds. The compounds were then further evaluated for biochemical properties, and it was found that one of the conjugates possessed similar functions and characteristics to the natural NADH. This compound was evaluated in the active enzyme, enoate reductase; like NADH, it was shown to help reduce the C=C double bond of three substrates and even outperformed the natural coenzyme. Kinetic data are reported.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Biochemical Evaluation of Nicotinamide Derivatives as NADH Analogue Coenzymes in Ene Reductase

et al. 2019

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“…[116] Cannella et al schlugen den Einsatz von chlorophyllartigen Pigmenten (z. Indirekte Photoaktivierung von Redoxenzymen [6,11,119,120] Die biokatalytische Oxidation von Substraten durch oxidierte Kofaktoren [z. [117] Nach 10-minütiger Bestrahlung mit Sonnenlicht lag die TOFd es Chlorophyllin/ LPMO-Hybridsystems in der Oxidation von mit Phosphorsäure gequollener Zellulose bei 1.98 10 3 h À1 und damit um zwei Grçßenordnungen hçher als zuvor erreichte Werte.…”

Section: Nitrogenasenunclassified

Photobiokatalyse: Aktivierung von Redoxenzymen durch direkten oder indirekten Transfer photoinduzierter Elektronen

et al. 2018

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Biokatalytische Umsetzungen rücken aufgrund der Vielfältigkeit der Enzyme, ihrer hohen katalytischen Aktivität und Spezifität und der milden Reaktionsbedingungen zunehmend in den Fokus einer “grünen” Synthesechemie. Der Ansatz, Sonnenenergie durch Kombination von Photokatalyse und Biokatalyse für die chemische Synthese nutzbar zu machen, bietet eine Möglichkeit, diesen “grünen” Prozess noch nachhaltiger zu gestalten. Oxidoreduktasen katalysieren die Umsetzung verschiedener Substrate durch den Austausch von Elektronen am aktiven Zentrum des Enzyms, meist mithilfe von Elektronenmediatoren. Aktuelle Fortschritte auf diesem Gebiet zeigen, dass photoinduzierter Elektronentransfer unter Einsatz organischer (oder anorganischer) Photosensibilisatoren ein breites Spektrum von Redoxenzymen aktivieren kann, welche in Folge wichtige Brennstoffe liefern (z. B. H2‐Bildung, CO2‐Reduktion) oder synthetisch relevante Reduktionen vermitteln (z. B. asymmetrische Reduktionen, Oxygenierungen, Hydroxylierungen, Epoxidierungen, Bayer‐Villiger‐Oxidation). Dieser Aufsatz gibt einen Überblick über aktuelle Entwicklungen auf dem Gebiet der Photoaktivierung von Redoxenzymen mittels direkter oder indirekter Übertragung photoinduzierter Elektronen.

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“…The Table 3 provides an overview of target molecules that could potentially be detected by bio-catalytic photo-organic sensors. Valuable targets for optical monitoring in microfluidic devices or LOC-applications include fluorescent cosubstrates such as adenosine triphosphate (ATP) [54], nicotinamide adenine dinucleotide (NADH) [55][56][57][58][59] and flavin adenine dinucleotide (FAD) [60]. These substances can be used to either monitor activities of various enzymes, e.g., oxygenases or dehydrogenases, which are widely applied in biotechnology.…”

Section: Potential Of Bio-catalytic Organic Sensorsmentioning

confidence: 99%

Exploiting the Potential of OLED-Based Photo-Organic Sensors for Biotechnological Applications

Krujatz¹,

Or²,

Fehse³

et al. 2016

Chem Sci J

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Recent Trends in Biomimetic NADH Regeneration

Cited by 85 publications

References 55 publications

Synthesis and Biochemical Evaluation of Nicotinamide Derivatives as NADH Analogue Coenzymes in Ene Reductase

Synthesis and Biochemical Evaluation of Nicotinamide Derivatives as NADH Analogue Coenzymes in Ene Reductase

Photobiokatalyse: Aktivierung von Redoxenzymen durch direkten oder indirekten Transfer photoinduzierter Elektronen

Exploiting the Potential of OLED-Based Photo-Organic Sensors for Biotechnological Applications

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