Recent trends in molecular epidemiology of Hepatitis C virus in Mardan, KPK Pakistan

Wahid, Braira; Waqar, Muhammad; Rasool, Nouman; Rehman, Zobaria; Saeed, Jamaluddin; Wasim, Muhammad; Khan, Muhammad Arif; Ali, Amjad; Rafique, Shazia; Sajjad, .; Idrees, Muhammad

doi:10.1016/j.meegid.2018.09.003

Cited by 7 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of HBV DNA was found higher in males as compared to females. This is in line with several other studies conducted in various areas of Pakistan as well as other countries which also showed that the prevalence of HBV is higher in males as compared to females (25,(27)(28)(29)(30). For this study, the patients were categorized in various age groups that are 1-20 years, 21-40 years, 41-60 years, and > 60 years, respectively.…”

Section: Discussionsupporting

confidence: 92%

Hepatitis B Virus (HBV) a Severe Health Problem in Mardan, Khyber Pakhtunkhwa: A Molecular Based Study

Khan¹,

Waqar

Rehman

et al. 2019

BSR

Self Cite

View full text Add to dashboard Cite

Hepatitis B is a severe health issue in both developed and developing countries that infects approximately 3.5 billion individuals globally. HBV infection is a more contagious disease than HCV and HIV infection. The current research work was conducted at D.H.Q hospital, Mardan Khyber Pakhtoon Khwa (KPK). Only HBsAg positive patients (n=750) were selected and for further confirmation of HBV DNA in all patients, Real Time PCR was performed. Out of a total of 750 patients, 34.6 % (n=260) patients were found to be HBV positive using Real Time PCR method. Prevalence of HBV DNA was high in male patients (p= 0.0151) as compared to female patients and also in patients of older age (>60 years). All patients were divided into three groups on the basis of viral load, that is, low viral load 100-10000 IU/ml, intermediate viral load 100,000-10,000,000 IU/ml, and high viral load >10,000,000 IU/ml. The study showed that 61.15% patients were placed in intermediate viral load category. All the HBV DNA positive patients were also screened for HBeAg and 31.53% were found reactive for HBeAg. This study provides a clear spectrum of molecular epidemiology of HBV in the Mardan region of KPK, Pakistan.

show abstract

Section: Discussionsupporting

confidence: 92%

Hepatitis B Virus (HBV) a Severe Health Problem in Mardan, Khyber Pakhtunkhwa: A Molecular Based Study

Khan¹,

Waqar

Rehman

et al. 2019

BSR

Self Cite

View full text Add to dashboard Cite

show abstract

“…In a study, anti-HCV prevalence was as follows: 1.0% for 20-29 years, 4.3% for 40-49 years, 1.6% for 50-59 years, and 0.9% for 60 years of age and above (26). Another study reported similar findings with higher HCV prevalence in those aged 40-49 years (28) while the lowest rate of HCV infection was observed in those above 60 and under 19 years of age. A study in Tokat region of our country showed an increasing age-specific prevalence starting from 40 years of age with rates reported as 4.2% for those aged 50-59 years, 3.4% for those aged 60-69 years, and 7.1% for those aged 70-79 years, which is the highest (11).…”

Section: Discussionmentioning

confidence: 76%

Chronic Hepatitis C Prevalence and Physician Awareness in Southeastern Turkey

Tunç¹

2019

vhd

View full text Add to dashboard Cite

Introduction Chronic hepatitis C (HCV) is a major global pathogen and the relevant public health problems are expected be increased in the upcoming years (1,2). Even though chronic HCV is endemic worldwide, its distribution considerably varies by geographic location (3). The highest prevalence rates are reported in Africa and Asia while the regions with low prevalence include the developed countries in North America, Northern and Western Europe, and Australia. Three percentage of world population is chronically infected with chronic HCV, representing an important cause of chronic liver diseases such as cirrhosis, liver fibrosis, hepatocellular

show abstract

“…Hepatitis C virus genotype 4a seems to be very rare in Pakistan. However, in 2018 Wahid et al (24) in Mardan and in 2010 Abdulkarim et al (25) in Lahore, reported genotype 4a in Pakistan. The rare occurrence of genotype 4a has been reported in neighboring countries like Iran, Iraq and UAE (26).…”

Section: Discussionmentioning

confidence: 97%

Molecular Epidemiology of Hepatitis C Virus Genotypes Among Chronically Infected Patients in Pakistan

Khan

Ali

Badshah

et al. 2019

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background:A number of studies on the distribution of hepatitis C virus (HCV) genotypes among the chronically HCV-infected people have reported different patterns from various geographical regions of Pakistan. A relatively large scale epidemiological study was needed in order to figure out the distribution pattern of HCV genotypes.Objectives: This research study was carried out to investigate the distribution pattern of hepatitis C virus genotypes in different geographical regions of Pakistan. Methods: In the current study, 5259 randomly selected patients with different genders, ethnicity, age groups, belonging to 24 geographical locations of Pakistan were included. Blood samples from patients with a positive history of active HCV infection were collected from various healthcare units from February 2016 to September 2018. Hepatitis C virus RNA was detected in serum samples by qualitative PCR and confirmed by real-time PCR. Hepatitis C virus genotyping analysis was performed by type specific PCR. Results: Our study revealed that out of 5259 HCV infected patients, HCV genotype 3a was the most frequent one (n = 4203, 79.9%) in all of the 24 regions of Pakistan, especially in Rawalpindi and Islamabad (Twin cities). Untypeable genotype (n = 415, 7.9%) was the second most frequent one after 3a followed by 3a3b co-infection (n = 355, 6.7%), 3b (n = 182, 3.5%), 2a (n = 92, 1.7%), 2b (n = 10, 0.2%), and 1b (n = 2, 0.03%). Interestingly, rarely detectable genotype 4 (n = 1, 0.01%) was also reported. The overall distribution pattern of HCV genotypes was the same in both the genders. Comparatively higher HCV chronic infection was reported among patientwith age group (41 -55). Conclusions: Currently the existing distribution pattern of HCV genotypes in Pakistan is similar to slight variations in some regions. Comparative analysis of the HCV genotype distribution indicated that the dynamics of HCV genotypes has changed in different areas with the emergence of a relatively uniform pattern across the country.

show abstract

Recent trends in molecular epidemiology of Hepatitis C virus in Mardan, KPK Pakistan

Cited by 7 publications

References 37 publications

Hepatitis B Virus (HBV) a Severe Health Problem in Mardan, Khyber Pakhtunkhwa: A Molecular Based Study

Hepatitis B Virus (HBV) a Severe Health Problem in Mardan, Khyber Pakhtunkhwa: A Molecular Based Study

Chronic Hepatitis C Prevalence and Physician Awareness in Southeastern Turkey

Molecular Epidemiology of Hepatitis C Virus Genotypes Among Chronically Infected Patients in Pakistan

Contact Info

Product

Resources

About