Recent Trends in Nanocarrier-Based Targeted Chemotherapy: Selective Delivery of Anticancer Drugs for Effective Lung, Colon, Cervical, and Breast Cancer Treatment

Abstract

<jats:p>Chemotherapy drugs are cytotoxic to tumor cells, but their lack of specificity leads to a range of side effects. The off-target effects of such drugs can be improved through the use of nanoparticles (NPs). Administered NPs show enhanced accumulation in tumor tissue near the blood vessels, enhancing both anticancer drug permeability and tumor retention. Several nanocarriers are now approved for clinical use in a range of cancer therapies, and many novel formulations are in the later stages of clinical trials. Here, we describe the advances in this area through the review of novel NP drug formulations developed over the last year. We focus specifically on lung, colon, cervical, and breast cancers and discuss the future of NPs as potential treatment options in these areas.</jats:p>

Targeted Drug Delivery — From Magic Bullet to Nanomedicine: Principles, Challenges, and Future Perspectives

“…Small nanocarriers with those tumor properties are believed to be suited for passive targeting of anticancer drugs, at relatively smaller dimensions than abnormal blood-vessel gaps, and can easily reach and selectively localize tumors. 22 However, recent studies have demonstrated that interendothelial gaps on tumors are not responsible for NP transport and accumulation into solid tumors. One study found that active processes take place for up to 97% of NP transport into tumors through endothelial cells.…”

Therapeutic Nanomaterials for Neurological Diseases and Cancer Therapy

“…But same as lipid-based nanomaterials, there are still many restrictions waiting to be overcome. Ideally, safe 6 Journal of Nanomaterials nanomaterials that could be loaded with various drugs and be able to target the specific cells in the brain remotely are highly expected.…”

“…In addition, specially designed nanomaterials can also improve the thrombolytic process of ischemic stroke and the effect of stem cell transplantation. Similarly, in cancer treatment, nanomaterials rely on their unique advantages to accurately target some biotoxic drugs to cancer tissues without causing damage to normal tissues [6].…”

DNA Based and Stimuli-Responsive Smart Nanocarrier for Diagnosis and Treatment of Cancer: Applications and Challenges

“…Nanoparticle based drug delivery systems are being extensively implemented in conventional approaches and combinational therapies of cancer treatment. These nanocarriers have shown improved efficacy, selectivity, stability, bio distribution, biocompatibility, and pharmacokinetics of anti-cancer drugs while overcoming the issues of multiple drug resistance and toxicity [ 13 , 14 ]. A variety of payloads, e.g., imaging agents, antibodies, photosensitizers, nucleic acids, and anti-cancer drugs can be loaded into these nanocarriers making them a versatile platform.…”