Recent Trends in Plant-Derived Antifungal Agents

Abstract

Recent years have witnessed emergence of resistance to azoles and other antifungal compounds. Moreover, the existing antifungal compounds for the contemporary clinicians are limited in numbers as opposed to available antibacterial compounds. Hence there is a real need to search for newer compounds with potential antifungal activity. In this review, the potential of medicinal plant species to yield newer antifungal agents would be illustrated with an emphasis on compounds discovered in recent years. Some of the issues pertinent to this area, including their botanical, medicinal, and available spectroscopic data, will briefly be reviewed and it is hoped that this would definitely stimulate for their discussions and researches on this important aspect including the mechanism of actions of these recently discovered compounds.

Hypofolins A – L, ent‐Labdane Diterpenoids from the Roots of Hypoestes phyllostachya ‘Pink Splash’

“…Hypofolins C (3) and D (4) both showed the same molecular formula, C 21 (11). The (E)-configuration of D 12 was confirmed by a ROESY correlation between H-C (14) and H-C (12). Therefore, compound 3 was identified as methyl (4R,12E)-2-oxo-ent-labda-8(17),12,14-trien-19-oate.…”

“…Species of the genus Hypoestes are used in fork medicine for the treatment of high blood pressure, cancer, infection vaginitis, and heart diseases, and as antipyretic and antiphlogistic agents . Phytochemically, plants of the genus Hypoestes are rich sources of diterpenoids, which display a variety of bioactivities including anti‐cancer, anti‐inflammatory, antifungal, antiparasitic, and cytotoxic activities . Especially, hypoestoxide, a novel verticillane diterpenoid isolated from Hypoestes rosea , has attracted much attention from biologists and has been reported to exhibit anti‐inflammatory and anti‐cancer activities …”

Recent Advances in the Chemistry of Bioactive Compounds from Plants and Soil Microbes: a Review

“…In its entirety therefore, the bioactive compounds have revolutionized the medicinal world. The antitumoral, antifungal, anticancer, antimalarial and antibacterial drugs have been known and discovered from medicinal plants in the past decades [59][60][61]. However, the fungal pathogens have grown resistance overtime against the antifungal drugs during the last 10-15 years.…”

Identification of Antifungal Compounds from Piper Plants Against Fusarium oxysporum: An Untargeted Metabolite Profiling-Based Approach

“…7 Therefore, Piper species can be considered an excellent source of antifungals and, consequently, several of them remain to be explored. 8,9…”

“…7 Therefore, Piper species can be considered an excellent source of antifungals and, consequently, several of them remain to be explored. 8,9 A critical current fungal-related problem concerns Fusarium oxysporum, a phytopathogen that infects and negatively affects above 100 crop plants worldwide and even humans. 10 Therefore, various strategies based on physical, biological, and/or chemical actions have been implemented to control this fungus.…”