Recent trends in prevention of oral cancer

Mangalath, Ummar; Aslam, Sachin; Khadar, Abdul Hafiz Kooliyat Abdul; Francis, Pulikkan George; Mikacha, Muhamed Shaloob Karimbil; Kalathingal, Jubin Hassan

doi:10.4103/2231-0762.149018

Cited by 36 publications

(16 citation statements)

References 10 publications

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“…This is due to the fact that reinforcement of awareness on oral cancer can possibly lead to detection of early clinical presentation and hence early diagnosis. Moreover, oral cancer can be reduced by limiting the risk factors and early detection of signs and symptoms [1, 18]. …”

Section: Introductionmentioning

confidence: 99%

Oral Cancer Awareness Among Dental Patients in Omdurman, Sudan: a cross-sectional Study

et al. 2017

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BackgroundOral cancer is a preventable disease. Its occurrence is mostly due to lifestyle. In Sudan, the use of smokeless tobacco (Toombak) has long been linked to oral cancer. Knowledge of the signs and symptoms of oral cancer may well aid in early diagnosis and treatment. This is bound to result in increasing survival rates, as well as reducing the oral cancer burden on the society. This study aimed to assess oral cancer awareness regarding knowledge of signs, symptoms, risk factors and sources of the information. Furthermore, it attempts to evaluate attitudes towards oral cancer screening and any previous experience of screening, amongst dental patients attending University of Science and Technology (UST) Dental Teaching Hospital. Omdurman, Sudan.MethodsA hospital based cross-sectional study, interviewer-administered questionnaire was conducted amongst 500 adult patients attending the UST Dental Hospital during 2015.ResultsA total of 57.7% (286) of the individuals demonstrated good knowledge of signs and symptoms, whereas 49% (139) expressed good knowledge of risk factors of oral cancer. For the majority of the individuals 66.1% (290), the most common source of information about oral cancer was from the media, while 33.9% individuals (149), obtained knowledge from direct contact of health workers. The overwhelming majority, 93.2% (466) never screened for oral cancer despite their positive attitude towards it 66.4% (332). Knowledge of risk factors associated significantly with those reported positive attitude towards oral cancer screening and those reported direct contact with health workers as a source of information, (p ≤ 0.001). Moreover, females and those living in urban districts scores higher than their counterpart in knowledge of risk factor of oral cancer. In addition, those employed 58.6% (280) and 62.8% (164) with correct believes about oral cancer showed significant association with positive knowledge of signs and symptoms (p ≤ 0.05).ConclusionsAwareness levels, knowledge of risk factors and identifying early signs and symptoms of oral cancer necessitate the need for more structured preventive programs using media. Dentists and health workers should do more because they have a pivotal role in early diagnosis by performing oral cancer screening, raising levels of knowledge and in rectifying misconceptions about oral cancer. This would entail a reduction in high rates of morbidity and mortality associated with oral cancer.Electronic supplementary materialThe online version of this article (doi:10.1186/s12903-017-0351-z) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Oral Cancer Awareness Among Dental Patients in Omdurman, Sudan: a cross-sectional Study

et al. 2017

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“…Half of these cases comprise of squamous cell carcinoma within the oral cavity or on the lip [1]. The progress of oral cancer is associated with multistep biological events, and the key threats to its association with the advancement of OSCC are alcohol consumption, tobacco [2], genetic mutation, tobacco-free products, and human papilloma virus (HPV) infections [3][4][5]. Global scenario shows that every year around 600,000 peoples are affected by head and neck cancer.…”

Section: Introductionmentioning

confidence: 99%

Identification of RAB2A and PRDX1 as the potential biomarkers for oral squamous cell carcinoma using mass spectrometry-based comparative proteomic approach

et al. 2015

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Despite the recent advances in diagnostic and therapeutic strategies, oral squamous cell carcinoma (OSCC) remains a major health burden. Protein biomarker discovery for early detection will help to improve patient survival rate in OSCC. Mass spectrometry-based proteomics has emerged as an excellent approach for detection of protein biomarkers in various types of cancers. In the current study, we have used 4-Plex isobaric tags for relative and absolute quantitation (iTRAQ)-based shotgun quantitative proteomic approach to identify proteins that are differentially expressed in cancerous tissues compared to normal tissues. The high-resolution mass spectrometric analysis resulted in identifying 2,074 proteins, among which 288 proteins were differentially expressed. Further, it was noticed that 162 proteins were upregulated, while 125 proteins were downregulated in OSCC-derived cancer tissue samples as compared to the adjacent normal tissues. We identified some of the known molecules which were reported earlier in OSCC such as MMP-9 (8.4-fold), ZNF142 (5.6-fold), and S100A7 (3.5-fold). Apart from this, we have also identified some novel signature proteins which have not been reported earlier in OSCC including ras-related protein Rab-2A isoform, RAB2A (4.6-fold), and peroxiredoxin-1, PRDX1 (2.2-fold). The immunohistochemistry-based validation using tissue microarray slides in OSCC revealed overexpression of the RAB2A and PRDX1 gene in 80 and 68 % of the tested clinical cases, respectively. This study will not only serve as a resource of candidate biomarkers but will contribute towards the existing knowledge on the role of the candidate molecules towards disease progression and therapeutic potential.

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“…Although the variable smoking status was not contemplated in the present study, smoking was associated with a greater number of decayed teeth in blacks and MexicanAmericans, [26] nevertheless, Colombia has one of the lowest prevalence of smoking in Latin America [30,31] and this fact could not affect the frequency on SRDC in the present study. Besides, smoking is more associated with oral cancer, periodontitis and worst wound healing [32,33].…”

Section: Discussionmentioning

confidence: 99%

A Multilevel Approach on Self-Reported Dental Caries in Subjects of Minority Ethnic Groups: A Cross-Sectional Study of 6440 Adults

Medina

Posada-López

Agudelo‐Suárez

2015

J Immigrant Minority Health

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Regional contextual factors and dental caries using multilevel modeling related to adults in minority ethnic groups have been scantily explored. The influence of the socioeconomic context on self-reported dental caries (SRDC) in individuals of minority ethnic groups (IEG) in Colombia was studied. Data from the 2007 National Public Health Survey were collected in 34,843 participants of the population. The influence of different factors on SRDC in IEG was investigated with logistic and multilevel regression analyses. A total of 6440 individuals belonged to an ethnic group. Multilevel analysis showed a significant variance in SRDC that was smaller in IEG level than between states. Multilevel multivariate analysis also associated SRDC with increasing age, lower education level, last dental visit >1 year, unmet dental need and low Gross Domestic Product (GDP). Minority ethnic groups were at risk to report higher dental caries, where low GDP was an important variable to be considered.

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Recent trends in prevention of oral cancer

Cited by 36 publications

References 10 publications

Oral Cancer Awareness Among Dental Patients in Omdurman, Sudan: a cross-sectional Study

Oral Cancer Awareness Among Dental Patients in Omdurman, Sudan: a cross-sectional Study

Identification of RAB2A and PRDX1 as the potential biomarkers for oral squamous cell carcinoma using mass spectrometry-based comparative proteomic approach

A Multilevel Approach on Self-Reported Dental Caries in Subjects of Minority Ethnic Groups: A Cross-Sectional Study of 6440 Adults

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