Recent trends in the chemistry of 2-aminobenzothiazoles

Synthesis and anti-oomycete activity of novel quinazolin- and benzothiazol-6-yloxyacetamides: Potent aza-analogs and five-ring analogs of quinoline fungicides

“…This standard 2-aminobenzothiazole synthesis proceeds via an ortho-thiocyanato-aniline intermediate, which undergoes ring closure by reaction with bromine. [16][17][18] For the following deamination we applied Chedekel's conditions 19,20 with sodium nitrite and phosphinic acid. The ether cleavage of the resulting methoxy-substituted benzothiazole 25 delivered the desired 4-chloro-6-hydroxybenzothiazole 26.…”

Synthesis and antimicrobial activity of pyrazolinones and pyrazoles having benzothiazole moiety

“…Benzothiazole moiety is of great importance to chemists as well as biologists as it is found in a large variety of naturally occurring compounds and it is also chemically useful molecule having diverse biological properties (Bondock et al, 2009). A large range of benzothiazole derivatives were reported having anticancer (Brantley et al, 2006), anticonvulsant (Rana et al, 2008), antiinflammatory (Naik et al, 1996), and antimicrobial activities (Amir et al, 2009;Bondock et al, 2010;Franchini et al, 2009;Soni et al, 2010;Ebara et al, 2005) (Fig.…”

Behavior of 2-cyano-3-(dimethylamino)-N-(4-phenylthiazol-2-yl)acrylamide towards some nitrogen nucleophiles

“…[15][16][17][18][19] These compounds were found to be associated with a wide range of chemotherapeutic activities. 20 In continuation of our interest in the synthesis of heterocycles containing a thiazole moiety [21][22][23][24][25][26][27][28] , we report herein the results of our study of the reactions of an enaminonitrile 2 with several nitrogen nucleophiles. The aim of the present paper is to present an efficient synthesis of novel 2-heteroaryl-thiazoles, which have not been reported hitherto.…”