Recent trends in the design and delivery strategies of ruthenium complexes for breast cancer therapy

Das, Utpal; Basu, Uttara; Paira, Priyankar

doi:10.1039/d4dt01482k

Dalton Trans.

2024

DOI: 10.1039/d4dt01482k

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Recent trends in the design and delivery strategies of ruthenium complexes for breast cancer therapy

Utpal Das,

Uttara Basu,

Priyankar Paira

Abstract: As the most frequent and deadly type of cancer in women, breast cancer has a high propensity to spread to the brain, bones, lymph nodes, and lungs. The discovery...

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2024

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Dinuclear Ru(II) Complexes Containing Tetrapyrido[3,2‐a : 2,3‐c : 3,2‐h : 2′′′,3′′′‐j]Phenazine Ligand for Biomedical Applications

Kushwaha,

Banerjee

2024

ChemBioChem

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Ruthenium complexes are among the most extensively studied and developed luminescent transition‐metal complexes for anticancer applications. Dinuclear Ru(II) complexes have caught significant interest for larger size, higher charge, and variable complex shapes. In this concept, we explore past and recent works on the possible biological applications of versatile tetrapyrido[3,2‐a:2,3‐c:3,2‐h:2‴,3‴‐j]phenazine (tppz)‐based dinuclear Ru(II) complexes with a focus on their use as quadruplex DNA probes, organelle imaging, and phototherapeutic agents. This concept also points out that a particular type of dinuclear Ru(II) complexes can act as multitargeting and multifunctional anticancer agents ‐making this an exciting area in which an array of further applications will likely emerge.

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Dinuclear Ru(II) Complexes Containing Tetrapyrido[3,2‐a : 2,3‐c : 3,2‐h : 2′′′,3′′′‐j]Phenazine Ligand for Biomedical Applications

Kushwaha,

Banerjee

2024

ChemBioChem

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show abstract

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Recent trends in the design and delivery strategies of ruthenium complexes for breast cancer therapy

Abstract: As the most frequent and deadly type of cancer in women, breast cancer has a high propensity to spread to the brain, bones, lymph nodes, and lungs. The discovery...

Cited by 1 publication

References 164 publications

Dinuclear Ru(II) Complexes Containing Tetrapyrido[3,2‐a : 2,3‐c : 3,2‐h : 2′′′,3′′′‐j]Phenazine Ligand for Biomedical Applications

Dinuclear Ru(II) Complexes Containing Tetrapyrido[3,2‐a : 2,3‐c : 3,2‐h : 2′′′,3′′′‐j]Phenazine Ligand for Biomedical Applications

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