Recent trends in the epidemiology of inflammatory bowel diseases: Up or down

Abstract

Inflammatory bowel disease (IBD) is traditionally considered to be common in the Western world, and its incidence has sharply increased since the early 1950s. In contrast, until the last decade, low prevalence and incidence rates have been reported from other parts of the world including Eastern Europe, South America, Asia and the Pacific region. Recent trends indicate a change in the epidemiology of IBD with previously low incidence areas now reporting a progressive rise in the incidence, while in West European and North American countries the figures have stabilized or slightly increased, with decreasing incidence rates for ulcerative colitis. Some of these changes may represent differences in diagnostic practices and increasing awareness of the disease. The quality of studies is also variable. Additional epidemiologic studies are needed to better define the burden of illness, explore the mechanism of association with environmental factors, and identify new risk factors.

A novel shift in estrogen receptor expression occurs as estradiol suppresses inflammation-associated colon tumor formation

“…It demonstrates that E 2 is protective against inflammationassociated colon tumor formation, which is important because it is estimated that up to 396/100 000 people worldwide suffer from IBD, increasing their risk of developing colon cancer (Lakatos 2006). Additionally, E 2 protected against the development of tumors even when introduced into the system following the initiation of inflammation and DNA damage to the colonic tissues.…”

"Role of Psychosocial Factors on the Course of Inflammatory Bowel Disease and Associated Psychotherapeutic Approaches. A Fresh Perspective and Review"

“…Likewise, IBD patients have a lower health related quality of life (HRQoL) than the general population, which is influenced by extreme fatigue, and the early age of onset and chronic course of IBD [2,3,15,16]. The worldwide incidence of UC lies between 0.5-24.5/100 000 persons, while that of CD falls between 0.1-16/100 000 persons [17]. The prevalence of IBD is estimated to be 396/100 000 persons and increases until 50-59 years with females being slightly higher represented [10,17].…”

“…The worldwide incidence of UC lies between 0.5-24.5/100 000 persons, while that of CD falls between 0.1-16/100 000 persons [17]. The prevalence of IBD is estimated to be 396/100 000 persons and increases until 50-59 years with females being slightly higher represented [10,17]. Nearly 1.4 million people in the United States and 2.2 million in Europe suffer from IBD [18].…”

Decision Tree Construction and Cost-Effectiveness Analysis of Treatment of Ulcerative Colitis With Pentasa®mesalazine 2 G Sachet

“…Its incidence varies widely around the world (between 0.5 and 24.5/10 5 inhabitants in the world), and it is more common in developed and industrialized countries. Its peak incidence is between 10 and 40 years old (5,19,21) . National data on the epidemiology of UURC are rare, but a study conducted in the Midwestern region of the state of São Paulo with 533,508 inhabitants showed incidence of 4.48/10 5 inhabitants and prevalence of 14.81/10 5 inhabitants (29) .…”