Recent Trends in the Sociodemographic, Clinical Profile and Psychiatric Comorbidity Associated with Posttraumatic Stress Disorder: A Study from Kashmir, India

Shoib, Sheikh; Mushtaq, Raheel; Jeelani, Snowber; Ahmad, Javeed; Dar, Mohammad Maqbool; Shah, Tabindah

doi:10.7860/jcdr/2014/7885.4282

Cited by 8 publications

(13 citation statements)

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“…The period of insurgency during this era of turmoil affected education and employment sector, which have negative consequences on youth. The population living in this region presented with somatic features like headache and pain initially, which were then subsequently diagnosed as psychiatric disorder on follow ups [16,17]. This may account for higher psychiatric disorders in headache patients.…”

Section: Discussionmentioning

confidence: 99%

Recognizing Risk of Psychiatric Comorbidity in Headache: Looking for Symptoms of Anxiety and Depression in Headache: A Study from General Hospital in Kashmir (India)

Shoib¹,

Mushtaq²,

Sofi³

et al. 2014

J Depress Anxiety

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Background: Headache is one of the most common neurological symptom that we come across, but very few well-planned studies have been conducted to know its psychiatric aspects .The aim of the study was to investigate the socio demographic profile, clinical types and psychiatric comorbidity in patients with various types of headache. Methods: We conducted a cross-sectional study for a period of one and a half years in Shri Maharaja Hari Singh hospital of Government medical college. The study was conducted in patients attending the medical outpatient department (OPD) for headache. The diagnosis of various types of headache was established by adopting the International Headache Society criteria (2004). A total of 200 patients were screened. Psychopathology was measured using MINI International Neuropsychiatric Interview Schedule PLUS (MINI PLUS). Descriptive statistics was used to report the socio-demographic characteristics of the patients. Chi-square was used to assess association between categorical variables and a p-value of significance was set at p ≤ 0.05. Results: Among 200 patients, there were 83 (41.5%) males and 117 (58.5%) females. Their ages ranged between 18 years to 78.5 years, with mean (± SD) of 35.85 (± 9.45) years. Psychiatric morbidity in headache was 47%. The psychiatric morbidity was more in females (53%) than males (38.6%) (P-value=0.044). It was also more in urban (58.3%) than rural areas (42.1%) (p-value= 0.036). Tension-type headache (48%) was the most predominate type of headache. Conclusion: Patients with headache had higher psychiatric morbidity. Screening patients with headache for psychiatric disorders and timely psychiatric intervention can go a long way in improving the quality of life of headache with comorbid psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Recognizing Risk of Psychiatric Comorbidity in Headache: Looking for Symptoms of Anxiety and Depression in Headache: A Study from General Hospital in Kashmir (India)

Shoib¹,

Mushtaq²,

Sofi³

et al. 2014

J Depress Anxiety

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“…These results provide further evidence for the remarkably high prevalence of PTSD and distress in female cancer patients. One explanation could be that women are more likely to perceive and articulate symptoms of emotional stress, and thus, it can be hypothesized that male patients underreport symptoms of psychological distress, resulting in underdiagnosis and undertreatment of psychiatric comorbidities . This potential lack of diagnosis and treatment might contribute to a lower quality of life and a worse outcome in female and male cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Screening for post‐traumatic stress disorders in 1017 cancer patients and correlation with anxiety, depression, and distress

et al. 2019

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ObjectivePost‐traumatic stress disorder (PTSD) is a severe psychiatric disorder, which might develop after a traumatic event, like cancer diagnosis, and threatens the patient's psychological and/or physiological integrity. Anxiety, depression, and mental distress are known to be common in cancer patients; however, the frequency of PTSD was not investigated thoroughly in this patient group so far. Here, we aim to screen cancer patients for PTSD symptoms and determine a possible correlation with anxiety, depression, and distress.MethodsThe study was performed at the Divisions of Hematology and Oncology of the Medical University of Vienna from 2010 to 2018. Following written consent, patients were asked to fill out the validated self‐assessment questionnaire for PTSS‐10 and HADS. The study was approved by the institutional ethics committee of the Medical University of Vienna (EC Nr: 2255/2016).ResultsA total of 1017 adult cancer patients (513 male, 504 female) were included in a cross‐sectional single‐center study. Mean age was 57.6 years (SD 14.4 years); 31.7%, 14.6%, 13.2%, and 27.4% of patients outscored the predefined thresholds for self‐assessed cases of PTSD, anxiety, depression, and distress, respectively. Compared with men, women showed a higher prevalence of symptoms for PTSD (38.9% vs 24.5%; P < .001) and anxiety (20.4% vs 8.6%; P < .001). The scores of HADS‐A, HADS‐D, and the combined HADS score (distress) were significantly correlated with PTSS‐10 scores (P < .01). No differences in age were observed among the different score groups.ConclusionThe study shows a significant prevalence as well as a correlation of PTSD symptoms with anxiety, depression, and distress among cancer patients. Findings underscore the necessity of a serious screening for psychiatric disorders, especially in female patients. In order to enable multidisciplinary care for cancer patients and to reduce the burden for psychiatric disorders, interdisciplinary screening and treatment concepts, which take into account gender aspects, are urged.

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“…There have been around 20,000 deaths and 4,000 disappearances in Kashmir (India) over the last 20 years. The lifetime prevalence of any trauma in Kashmir in 2006 was 59.50 percent for males and 57.39 percent for females [ 16 , 17 ]. The increase of depressive disorders in Kashmir (India) is primarily due to continual conflict, elevated stress in daily life and genetic factors.…”

Section: Discussionmentioning

confidence: 99%

Is there a link between Depressive Disorders and Tryptophan Hydroxylase 1 (TPH1) Gene Polymorphism? - Study from a Distressed Area, Kashmir (India)

Mushtaq

Tarfarosh

Dar

et al. 2016

Cureus

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BackgroundThe progress that man has made in all domains of life, during all these years of reign over the earth, is utterly remarkable. However, it always came at a price. Each epoch of progress has seen human beings inflicted with trauma and cynical consequences. During the last two decades, Kashmiri (Indian) people have experienced continuous violence, a reign of terror, and political turmoil. Each of these disastrous events has contributed to the increase in psychiatric disorders in this part of the world, especially major depressive disorders. We can observe that besides the environmental influences, gene polymorphism also plays a crucial role in the development of depressive disorders. The role of Tryptophan Hydroxylase 1 (TPH1) gene is implicated in various psychiatric disorders, including depression. However, no study has investigated TPH1 A779C gene polymorphism in depressive disorders in a distressed society like Kashmir (India).AimsTo study TPH1 A779C single nucleotide polymorphism in depressive disorders in Kashmiri (Indian) population.Materials and MethodsTwo hundred and forty patients diagnosed with depressive disorder, and 160 unrelated healthy volunteers (control), were studied in a case-control study design. Polymorphism was determined using polymerase chain reaction (PCR) and agarose gel electrophoresis, after digestion with HAP II enzyme. Genotypes and allele frequencies were compared using Chi-square tests, Fisher’s exact test, odds ratio, 95% confidence interval (C.I.) and a p-value of <0.05 was considered to be statistically significant.ResultsThe mean age ± standard deviation (SD) of depression and control group was 32.02±10.99 and 31.75±9.93, respectively (p= 0.512). It was found that the patients from depression group had AA genotype (51.7%) in comparison to control group (17.5%) and these results were statistically significant (p≤0.0001). Calculation of allelic frequency revealed a stronger association of A allele with depression group (70.83%) than with the control group (41.25%), and it was also found to be statistically significant (p≤0.0001) with C.I. of 3.459 (1.909-6.266).ConclusionTPH1 A779C A gene was found to be associated with a major depressive disorder (MDD) in Kashmiri (Indian) population. There were high HAM-A as well as HAM-D scores in depressive patients of Kashmir (India).

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Recent Trends in the Sociodemographic, Clinical Profile and Psychiatric Comorbidity Associated with Posttraumatic Stress Disorder: A Study from Kashmir, India

Cited by 8 publications

References 0 publications

Recognizing Risk of Psychiatric Comorbidity in Headache: Looking for Symptoms of Anxiety and Depression in Headache: A Study from General Hospital in Kashmir (India)

Recognizing Risk of Psychiatric Comorbidity in Headache: Looking for Symptoms of Anxiety and Depression in Headache: A Study from General Hospital in Kashmir (India)

Screening for post‐traumatic stress disorders in 1017 cancer patients and correlation with anxiety, depression, and distress

Is there a link between Depressive Disorders and Tryptophan Hydroxylase 1 (TPH1) Gene Polymorphism? - Study from a Distressed Area, Kashmir (India)

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