Recent update of autism spectrum disorders

Kim, Sung Koo

doi:10.3345/kjp.2015.58.1.8

Cited by 28 publications

(21 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Autism spectrum disorder is a neurodevelopment and cognitive disorder that is characterized by intellectual impairments in the acquisition of some of the most important life skills, including deficiencies in interpersonal and communication skills, impaired social interactions, and constrained and repetitive behaviors. 15,16 Autism spectrum disorder is approximately four times more prevalent in males than females, but it is more severe in females. Onset generally occurs during the first three years of life.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of primary dentition occlusion among preschool children with autism spectrum disorder

Aljubour

Al-Sehaibany

2018

JDHODT

View full text Add to dashboard Cite

Objective:To determine the characteristics of primary dentition occlusion among Saudi preschool children with autism spectrum disorder (ASD) and compare it with Saudi preschool children without ASD. Methods:This study was conducted on a randomly selected sample of 3-6 year old Saudi preschool children in Riyadh, Saudi Arabia. The sample consisted of a study group (SG) of 150 children with ASD and a control group (CG) of age-and gender-matched 150 children without ASD. Clinical examinations to determine primary molar relationship, primary canine relationship, overbite, overjet, posterior crossbite and scissors bite were performed at ASD centers and kindergartens.Results: Significant differences were found in the occlusal characteristics of the primary dentition between the SG and CG (p<0.05). Most children in the SG exhibited a distal step molar relationship (51.3%), a class II canine relationship (56.7%), and increased overjet and overbite. Most of the CG children exhibited a flush terminal molar relationship (83.3%), a class I canine relationship (77.3%), normal overbite and overjet. The prevalence of posterior crossbite was significantly higher in the SG than the CG (p=0.012). Conclusion:The data revealed that the prevalence of malocclusion was higher in Saudi preschool children with ASD than in non-ASD preschool children.Citation: Aljubour AA, Al-Sehaibany FS. Characteristics of primary dentition occlusion among preschool children with autism spectrum disorder.Citation: Aljubour AA, Al-Sehaibany FS. Characteristics of primary dentition occlusion among preschool children with autism spectrum disorder.

show abstract

Section: Introductionmentioning

confidence: 99%

Characteristics of primary dentition occlusion among preschool children with autism spectrum disorder

Aljubour

Al-Sehaibany

2018

JDHODT

View full text Add to dashboard Cite

show abstract

“…Cognitive deficits associated with ASD, as assessed by intelligence quotient tests, can range from intellectual disability to the superior range (Kim, 2015). In the past few years, there have been impressive advances in understanding the pathogenesis of these disorders.…”

Section: Introductionmentioning

confidence: 99%

Altered expression of circadian rhythm and extracellular matrix genes in the medial prefrontal cortex of a valproic acid rat model of autism

Loohuis¹,

Martens²,

Bokhoven³

et al. 2017

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

Autism spectrum disorders (ASD) are a highly heterogeneous group of neurodevelopmental disorders caused by complex interplay between various genes and environmental factors during embryonic development. Changes at the molecular, cellular and neuroanatomical levels are especially evident in the medial prefrontal cortex (mPFC) of ASD patients and are particularly contributing to social impairments. In the present study we tested the hypothesis that altered neuronal development and plasticity, as seen in the mPFC of ASD individuals, may result from aberrant expression of functionally connected genes. Toward this end, we combined transcriptome sequencing and computational gene ontology analysis to identify the molecular networks impaired in the mPFC of a valproic acid (VPA) rat model of autism. This investigation identified two subsets of genes differentially expressed in the mPFC of VPA rats: one group of genes being functionally involved in the regulation of the circadian rhythm, while the second group encompasses a set of differentially expressed collagen genes acting within the extracellular matrix. Ultimately, our integrated transcriptome analysis identified a distinct subset of altered gene networks in the mPFC of VPA rats, contributing to our understanding of autism at the molecular level, thus providing novel insight into the genetic alterations associated with this neurodevelopmental disorder.

show abstract

“…11 Studies recommended that among the developmental disorders, developmental language disorder was the second most common and in ASD it is an important part. 12 With this huge magnitude of disease burden of ASD children, their language problem is still under attended.…”

Section: Discussionmentioning

confidence: 99%

Language Problem in Bangladeshi Children with Autism spectrum disorder : Observation through a Neurolinguistics Approach

Ferdous

Yasmeen²,

Alam³

et al. 2018

Northern Int. Med. Coll. J.

View full text Add to dashboard Cite

Background : Autism spectrum disorder (ASD) covers a set of developmental disabilities that can cause significant social, communication, and behavioral challenges.Objective : It was aimed to find out the language problem in Bangladeshi children with Autism spectrum disorder following the neurolinguistics approach.Methodology : A descriptive observational study conducted during the period of April 2014 to December 2014 in the department of Linguistics, University of Dhaka, Bangladesh among the Bangladeshi children aged between 3–12 years. A total of 10 children with normal hearing ability who were diagnosed as ASD according to the diagnostic criteria (DSM- 5 or ICD 10) were enrolled in the study purposively from two tertiary care hospitals of Dhaka city.Results : In this study total 10 children were included and their age range was 3 to 12 years. Male was predominant (90%).Consanguinity of parents was not present in most (90%) cases,60% had positive family history of mental illness, 70% had history of delivery by lower uterine section, 80% of them were term baby. 100% children had delayed speech development, 90% was unable to indicate with index finger, 90% was unable to use noun and pronoun, 90% had repetitive words, 100% had inability to take part in rhymes, 90% was unable to play with symbols, 70% had no eye to eye contact, and 90% had no reciprocal social smile.Conclusion : Language problem in the children with ASD is an under attended problem in Bangladesh. To the authors’ best knowledge this is the first neurolinguistics approach to ASD children in Bangladesh. Further large scale extensive studies would be necessary for better visualization of the extent of the issue.Northern International Medical College Journal Vol.9(2) Jan 2018: 295-299

show abstract

Recent update of autism spectrum disorders

Cited by 28 publications

References 50 publications

Characteristics of primary dentition occlusion among preschool children with autism spectrum disorder

Characteristics of primary dentition occlusion among preschool children with autism spectrum disorder

Altered expression of circadian rhythm and extracellular matrix genes in the medial prefrontal cortex of a valproic acid rat model of autism

Language Problem in Bangladeshi Children with Autism spectrum disorder : Observation through a Neurolinguistics Approach

Contact Info

Product

Resources

About