Recent Update on Nanoemulgel as Topical Drug Delivery System

Choudhury, Hira; Gorain, Bapi; Pandey, Manisha; Chatterjee, Lipika; Sengupta, Pinaki; Das, Arindam; Molugulu, Nagashekhara; Kesharwani, Prashant

doi:10.1016/j.xphs.2017.03.042

Cited by 139 publications

(71 citation statements)

References 96 publications

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“…Herbal medicine, sometimes known as phytomedicine or botanical medicine, utilizes different parts of the plants, including its flowers, fruits, seeds, leaves, berries, bark and roots intended for medicinal purposes. 1 The use and delivery of herbal medicine as dosage form in treating and preventing of diseases has a long history started with use in Mesopotamia in 2600 B.C., 2 although the oldest record on practice of medicinal plants for drug preparation was engraved on a Sumerian clay slab, created over 5,000 years ago. 3 The use of medicinal plants are still continuing in this modern era, and it has been estimated that approximately one fourth of prescription medicines worldwide are derived from plants.…”

Section: Introductionmentioning

confidence: 99%

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

Choudhury

Pandey

Hua

et al. 2018

Journal of Traditional and Complementary Medicine

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358

192

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Herbal medicine, phytomedicine or botanical medicine are synonymous, utilizes plants intended for medicinal purposes. Medicinal use of herbal medicine in the treatment and prevention of diseases including diabetes has a long history compared to conventional medicine. Diabetes is one of the major public health concerns over the world. Diabetes or hyperglycemia is considered to be one of the common public health hazard; optimal control of which is still not possible. Persistent hyperglycemia or uncontrolled diabetes has the potential to cause serious complications such as kidney disease, vision loss, cardiovascular disease, and lower-limb amputations which contributed towards morbidity and mortality in diabetes. There are various approaches to treat and prevent diabetes as well as its secondary complications, one of it is herbal medicines. However, the selection of herbs might depends on several factors, which include the stage of progression of diabetes, types of comorbidities that the patients are having, availability, affordability as well as the safety profile of the herbs. This review focuses on the herbal and natural remedies that play the role in the treatment or prevention of this morbid disorder – diabetes, including their underlying mechanisms for the blood glucose-lowering property and the herbal products already been marketed for the remedial action of diabetes.

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Section: Introductionmentioning

confidence: 99%

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

Choudhury

Pandey

Hua

et al. 2018

Journal of Traditional and Complementary Medicine

Self Cite

358

192

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“…Delivering hydrophobic components using this NE platform makes this nanoformulation a widely explored tool, where the dispersed droplets of 10–200 nm promotes penetration of the drugs for therapeutic responses [ 22 , 23 ]. Incorporation of chitosan in the formulation is aimed towards overcoming its limitations in topical application, which will allow the formed gel to persist at the site of application for longer durations [ 24 ]. Thus, the NE formulation was developed using Capryol 90, Tween 20 and Transcutol P using a low-energy emulsification method.…”

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

et al. 2020

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The potential role of naringenin (NAR), a natural flavonoid, in the treatment of chronic wound has prompted the present research to deliver the drug in nanoemulsion (NE) form, where synergistic role of chitosan was achieved through development of chitosan-coated NAR NE (CNNE). The NE consisted of Capryol 90, Tween 20 and Transcutol P, which was fabricated by low-energy emulsification method to encapsulate NAR within the oil core. The optimization of the formulated NEs was performed using Box–Behnken statistical design to obtain crucial variable parameters that influence globule size, size distribution and surface charge. Finally, the optimized formulation was coated with different concentrations of chitosan and subsequently characterized in vitro. The size of the CNNE was found to be increased when the drug-loaded formulation was coated with chitosan. Controlled release characteristics depicted 67–81% release of NAR from the CNNE, compared to 89% from the NE formulation. Cytotoxicity study of the formulation was performed in vitro using fibroblast cell line (NIH-3T3), where no inhibition in proliferation of the cells was observed with CNNE. Finally, the wound healing potential of the CNNE was evaluated in an abrasion-created wound model in experimental animals where the animals were treated and compared histologically at 0 and 14 days. Significant improvement in construction of the abrasion wound was observed when the animals were treated with formulated CNNE, whereas stimulation of skin regeneration was depicted in the histological examination. Therefore, it could be summarized that the chitosan coating of the developed NAR NE is a potential platform to accelerate healing of wounds.

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“…As per the report, nanoemulsion has more solubilization ability than emulsion and suspension with long-time shelf life, recent improvement of delivery to transdermal skin formulation such as transparent gel and emulgel with havening better patient acceptance and increased effectiveness 3 . Even though it has better application, the topical formulation is restricted because of low spreadability and low viscosity hence the researcher solved this problem by transformation of nanoemulsion into nanoemulgel 4 . Nanoemulgel is the modified form of nanoemulsion either with oil in water or water in oil type incorporated with the gelling agent with better improved characteristic features with the nanoemulsion such as less irritation of the skin, enhanced permeability 5 .…”

Section: Ijpsr (2020) Volume 11 Issue 4 (Review Article)mentioning

confidence: 99%

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2020

IJPSR

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Nanoemulsion system is a promising vehicle due to the powerful ability to deliver the drug through the skin. Researchers have been conducted to prove its potential for the delivery of the drugs used in many skin disorders. Skin is the largest organ and acts as the first line of defense of our body. After a certain period of time, our skin loses tone and elasticity which is called aging. It is the result of programmed senescence and prolonged environmental injury to the skin. The aim of this review article is to provide information regarding the control of skin aging by the nanoemulsion drug delivery system. Novel carrier systems have a lot of advantages when compared to conventional formulations. There are various approaches to preventing skin aging. The most widely used age combating substances in cosmeceuticals are kinetin, Retinoids, sun filters, herbal ingredients (such as resveratrol, turmeric, and green tea), and antioxidants (such as alpha-tocopherol, ascorbic acid, coenzyme Q10 and lipoic acid). In recent years, these molecules have been formulated as nanosized carriers such as vesicular systems, Therefore, nanocarrier such as liposomes, noisome, microemulsions and nanoparticles have been widely investigated as delivery systems for antioxidants to improve their beneficial effects in the treatment of skin aging. In this review, an overview of cosmetic, product-oriented solutions for skin aging is given and different approaches to combat aging are summarized. This review discusses the role of oxidative events of tissue degeneration and aging in general, and for the skin in particular. The mechanisms involved in intrinsic and extrinsic (photo-) aging are described. To prevent or treat skin aging, topical supplementation with antioxidants is regarded as one of the most promising strategies. Overall review says that antioxidants are most commonly used in anti-aging cosmetic products will be reviewed along with the nanocarrier designed to improve their safety and effectiveness. INTRODUCTION: Nanoemulsion is a type of emulsion which is very fine and metastable in nature, the size of the droplets is smaller than the 100 nanometres. Based on the process used for the preparation of nanoemulsion their structure is identified.

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Recent Update on Nanoemulgel as Topical Drug Delivery System

Cited by 139 publications

References 96 publications

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

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