Recent Updates on Anticancer Activity of Betulin and Betulinic Acid Hybrids (A Review)

Exploring the Antimelanoma Potential of Betulinic Acid Esters and Their Liposomal Nanoformulations

“…Betulinic which can be found in many tree and plant species, shows a wide range of bi activities [30] including selective anticancer effects against numerous types of cance [31]; its ability to directly target mitochondria and trigger cancer death provid possibility of alternative anticancer treatment when conventional therapy fails Despite its promising anticarcinogenic effects, BA's low bioavailability has impelled researchers to synthesize new analogues that exhibit improved pharmacokineti pharmacodynamic profiles [33]. The chemical modulation of betulinic acid may le the synthesis of hybrid molecules that occupy a special place in the developm effective anticancer agents, since they provide the possibility to enhance and enlar biological effects of the parent molecule while circumventing drug resistance [34]. researchers reported that the biological activities of several pentacyclic triterpenes su amyrin, oleanolic acid, lupeol and ursolic acid might be improved through esterifi with fatty acids [19,35].…”

“…Despite its promising anticarcinogenic effects, BA's low bioavailability has impelled many researchers to synthesize new analogues that exhibit improved pharmacokinetic and pharmacodynamic profiles [33]. The chemical modulation of betulinic acid may lead to the synthesis of hybrid molecules that occupy a special place in the development of effective anticancer agents, since they provide the possibility to enhance and enlarge the biological effects of the parent molecule while circumventing drug resistance [34]. Some researchers reported that the biological activities of several pentacyclic triterpenes such as amyrin, oleanolic acid, lupeol and ursolic acid might be improved through esterification with fatty acids [19,35].…”