Recent updates on ocular disease management with ophthalmic ointments

Bisen, Amol Chhatrapati; Dubey, Ayush; Agrawal, Sristi; Biswas, Arpon; Rawat, Kundan Singh; Srivastava, Saurabh; Bhatta, Rabi Sankar

doi:10.1080/20415990.2024.2346047

Cited by 2 publications

(2 citation statements)

References 117 publications

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“…226 As of now, due to ease of administration, eye drops are the most accepted and widely used dosage form among other conventional dosage forms (suspension, gel, emulsions, and ointment) for treating a broad range of eye disorders. 226,227 Some key factors should be considered while preparing the formulation, including the appropriate selection of the drug and its salt, solvent solubility, ocular toxicity, and the effect of the pH on the formulation. 228−232 Other than this, the solution should be isotonic and should not be highly viscous, within the ocular buffering capacity, free from the interaction between the drug and selected excipients, choice of appropriate preservatives, ocular safety, and dosing administration.…”

Section: Limitations Of Current Therapymentioning

confidence: 99%

“…The solutions, suspensions, emulsions, and gels are still used in visual disease treatment . As of now, due to ease of administration, eye drops are the most accepted and widely used dosage form among other conventional dosage forms (suspension, gel, emulsions, and ointment) for treating a broad range of eye disorders. , Some key factors should be considered while preparing the formulation, including the appropriate selection of the drug and its salt, solvent solubility, ocular toxicity, and the effect of the pH on the formulation. − Other than this, the solution should be isotonic and should not be highly viscous, within the ocular buffering capacity, free from the interaction between the drug and selected excipients, choice of appropriate preservatives, ocular safety, and dosing administration. However, they have a few drawbacks, such as low bioavailability because of their physical attributes, such as irritable macroparticles, low penetration ability, less residence time at the ocular surface, lack of drug delivery to the posterior segment, and most drug wash-off because of tear dilution and turnover tend to frequent administration, which reduces patient compliance.…”

Section: Limitations Of Current Therapymentioning

confidence: 99%

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Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Bisen,

Sanap,

Agrawal

et al. 2024

ACS Infect. Dis.

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Fungal keratitis (FK) is a severe ocular condition resulting from corneal infection that is prevalent in tropical countries, particularly in developing regions of Asia and Africa. Factors like corneal lens misuse, inappropriate steroid use, and diagnostic challenges have provoked the epidemic. FK causes significant vision impairment, scarring, and ocular deformities. Accurate pathological diagnosis is crucial for effective therapeutic intervention. Topical antifungal therapy with surface healing medications proves effective in preventing fungal-borne ulcers. Managing FK requires a comprehensive understanding of fungal pathogenesis, guiding formulation strategies and preventive measures to curb global ocular blindness. This review provides in-depth insights into FK, covering etiology, epidemiology, pathogenesis, therapeutic interventions, antifungal resistance, limitations, prevention, and future perspectives on ocular surface disease management.

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Section: Limitations Of Current Therapymentioning

confidence: 99%

Section: Limitations Of Current Therapymentioning

confidence: 99%

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Bisen,

Sanap,

Agrawal

et al. 2024

ACS Infect. Dis.

Self Cite

View full text Add to dashboard Cite

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Pharmacokinetic Analysis of Gatifloxacin and Dexamethasone in Rabbit Ocular Biofluid Using a Sensitive and Selective LC–MS/MS Method

Biswas,

Choudhury,

Mishra

et al. 2024

J Mass Spectrom

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Bacterial keratitis (BK) is an infection that causes inflammation of the cornea and, if severe, can result in blindness. Topical fluoroquinolones combined with corticosteroids have been shown to be useful in the treatment of BK. A rapid, selective, and sensitive bioanalytical method for simultaneous quantification of Gatifloxacin (GAT) and Dexamethasone (DEX) has been developed and validated using tandem mass spectrometry (LC–MS/MS). Optimal separation was accomplished in under 5 min using an Agilent Zorbax C18 column (100 mm × 4.6 mm, 3.5 μm). The mobile phase was composed of a blend of 0.2% formic acid in triple distilled water and methanol with a flow rate of 0.65 mL/min in isocratic mode. GAT and DEX were detected in positive electrospray ionization multiple reaction monitoring mode (MRM), and the retention time was found to be at 1.64 and 2.93 min, respectively. The linearity of GAT and DEX was found to be in the range of 1.56–400 ng mL−1 with good precision and accuracy. The method was validated according to USFDA regulatory guidelines. The validated method was effectively utilized for preclinical pharmacokinetic analysis of GAT and DEX in rabbit tear fluid following the topical application of a commercial formulation.

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Recent updates on ocular disease management with ophthalmic ointments

Cited by 2 publications

References 117 publications

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Pharmacokinetic Analysis of Gatifloxacin and Dexamethasone in Rabbit Ocular Biofluid Using a Sensitive and Selective LC–MS/MS Method

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