Recent Updates on the Role of the MicroRNA-10 Family in Gynecological Malignancies

Abstract

The ever-increasing morbidity associated with gynecological malignancies constantly endangers the physical and psychological health of women. Since a long time, there has been an urgent need for a deeper understanding of the tumorigenesis and the development of gynecological cancer to identify new molecular markers for early diagnosis and metastatic disease prognosis and for the development of therapeutic targets. MicroRNAs are crucial cellular regulators. The microRNA-10 (miR-10) family has been found to play an integral role in the evolution of numerous cancer types. A comprehensive understanding of current studies on miR-10 could provide better insights into future research and clinical applications in related fields. This article reviews the latest research on the role of the miR-10 family in gynecological malignancies and the relevant molecular mechanism, mainly focusing on endometrial, cervical, and ovarian cancers.

Sustained Effectiveness and Safety of Therapeutic miR-10a/b in Alleviating Diabetes and Gastrointestinal Dysmotility without Inducing Cancer or Inflammation in Murine Liver and Colon

“…Notably, although overexpression of miR-10a/b-5p has been linked to cancer in various contexts [18][19][20], our study indicates that the five monthly doses of 500 ng/g of miR-10a/b mimics subcutaneously injected in diabetic mice are safe as they did not reach the excessive oncogenic levels of miR-10a/b-5p. miR-10a/b-5p are bifunctional in cancer as they function as both tumor suppressors and oncogenes, inhibiting or promoting cancer development and progression depending on the cellular contexts and the genes they target [25,26]. Overexpression of miR-10a/b-5p is associated with various types of cancers, contributing to enhanced cell proliferation and migration [18][19][20].…”

“…However, it is also well-documented that miR-10a/b-5p are downregulated in certain cancers and inhibit tumorigenicity [27][28][29][30]. miR-10a/b-5p have both oncogenic and tumor-suppressive roles in gastric cancer [26], colorectal cancer [31], breast cancer [32], and gynecological malignancies [25]. The dual function of miR-10a/b-5p is dependent on their target genes.…”