Recent use of medical infrared thermography in skin neoplasms

Magalhães, Cíntia Lopes de Brito; Vardasca, Ricardo; Mendes, Joaquim

doi:10.1111/srt.12469

Cited by 39 publications

(31 citation statements)

References 28 publications

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“…Because the method measures the temperature in a contactless manner over the surface, it has an advantage over contact measurement techniques like temperature sensors that have to be in contact with the observed material or media and can measure the temperature only at one point. Therefore, thermography also found practical use in medicine for various applications like breast cancer diagnostics, diagnosis of vascular disorder, fever screening, dental diagnostics, dermatological applications and blood pressure monitoring [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Numerical modelling of skin tumour tissue with temperature-dependent properties for dynamic thermography

Iljaž

Wrobel

Hriberšek

et al. 2019

Computers in Biology and Medicine

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Dynamic thermography has been clinically proven to be a valuable diagnostic technique for skin tumor detection as well as for other medical applications, and shows many advantages over static thermography. Numerical modelling of heat transfer phenomena in biological tissue during dynamic thermography can aid the technique by improving process parameters or by estimating unknown tissue parameters based on measurement data. This paper presents a new non-linear numerical model of multilayer skin tissue containing a skin tumour together with thermoregulation response of the tissue during the cooling-rewarming process of dynamic thermography. The thermoregulation response is modelled by temperature-dependent blood perfusion rate and metabolic heat generation. The aim is to describe bioheat transfer more realistically. The model is based on the Pennes bioheat equation and solved numerically using a subdomain BEM approach treating the problem as axisymmetrical. The paper includes computational tests for Clark II and Clark IV tumours, comparing the models using constant and temperature-dependent properties which showed noticeable differences and highlighted the importance of using a local thermoregulation model. Results also show the advantage of using dynamic thermography for skin tumour screening and detection at an early stage. One of the contributions of this paper is a complete sensitivity analysis of 56 model parameters based on the gradient of the surface temperature difference between tumour and healthy skin. The analysis shows that size of the tumour, blood perfusion rate, thermoregulation coefficient of the tumour, body core temperature and density and specific heat of the skin layers in which the tumour is embedded are important for modelling the problem, and so have to be determined more accurately to reflect realistic skin response of the investigated tissue, while metabolic heat generation and its thermoregulation are not.

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Section: Introductionmentioning

confidence: 99%

Numerical modelling of skin tumour tissue with temperature-dependent properties for dynamic thermography

Iljaž

Wrobel

Hriberšek

et al. 2019

Computers in Biology and Medicine

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show abstract

“…The use infrared thermography (IRT) is growing in popularity as a diagnostic tool for applied medicine or as outcome measure for clinical trials [5–8]. IRT allows imagining of the body surface temperature in real time with high sensitivity (up to 0.025°C) and accuracy up to 1% without physical contact [9–11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the temperature of posterior lower limbs skin during the whole body vibration measured by infrared thermography: Cross-sectional study analysis using linear mixed effect model

et al. 2019

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BackgroundWhole body vibration exercise (WBVE) has been shown to improve muscular strength and power, and increase peripheral blood flow. The aim of this study was to evaluate the behavior of the skin temperature (Tsk) on regions of the lower limbs from an acute bout of WBVE.Methods and findingsCross-sectional study approved by local ethics committee (Certificado de Apresentação para Apreciação Ética—CAAE—19826413.8.0000.5259) and Trial registration (Registro Brasileiro de Ensaios Clínicos—REBEC—RBR-738wng). Using Infrared thermography (IRT), Tsk and thermal symmetry of the posterior lower extremities (thigh, knee, calf and heel) were examined in 19 healthy participants. IRT was assessed during 60-second WBVE exposures of 0, 30 and 50 Hz. From the adjusted linear mixed effects model, vibration frequency, time and regions of the lower extremity were significant (p<0.001). However, the variable laterality was not significant (p = 0.067) and was excluded from the adjusted statistical model. The adjusted model was significant (p<0.00001) and all variables in the model were significant (p<0.01) indicating that Tsk decreases with time, independently of the vibration frequency. The value of the Pseudo-R-Squared for the model was 0.8376. The presented mathematical model of the current study may be useful to justify the patterns observed for all vibration frequencies between and 0 and 50 Hz. The main limitations of the study were the reduced time of the intervention and not having evaluated other regions of the body.ConclusionsThe acute exposure of 60-second mechanical vibration has effect on the behavior of Tsk of the posterior region of the lower limbs, which is likely to be associated with a decrease on the blood flow due to WBVE. It is speculated that during WBVE a greater supply of blood is required where the body responds by shunting blood flow from the skin to working muscle in the first seconds of exercise. Further investigative work is required to verify this hypothesis.

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“…Other forms of near‐infrared red radiation, including water filtered NIR, have been used to induce hyperthermia in management of other cancerous lesions, without causing discomfort 20 . IR thermal imaging has even been applied to characterize lesions as benign or malignant, and differentiate skin cancers 21 . The objective of this pilot study was to determine if the vasculature of normal skin and NMSC skin appears differently following heating with NIR light, and therefore, if this has applications on a larger scale for margin delineation.…”

Section: Introductionmentioning

confidence: 99%

Near‐infrared heating of skin to delineate non‐melanoma skin cancer lesions: A pilot study

Pianosi

Jordan

Moore

2020

Skin Research and Technology

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Background Surgical excision is a mainstay of treatment for non‐melanoma skin cancer (NMSC); improving margin delineation can reduce the need for further monitoring/treatment. The objective of this pilot study was to determine if near‐infrared radiation (NIR) application to skin causes visible changes in normal and NMSC skin, to help delineate margins. Materials/Methods Eleven biopsy‐proven NMSC lesions were included. The skin was then heated under a 175W NIR heating bulb; margins were traced onto acetate film before and after heating. Lesions were then randomly assigned to excision based on pre‐ or post‐heating margins. Composite images were generated by overlaying the heat and no‐heat lesion contours. All specimens were sent for histopathology. Results The range of closest margins in the control group was 2.0‐3.0 mm with a median of 2.0 mm; the range in the intervention group was 4.0‐9.0 mm with a median of 5.0 mm. Composite images showed larger heat contours when the initial lesion was larger. There was a statistically significant difference between the two groups. Overall, NIR light caused visible hyperaemia to skin, and more intense erythema to malignant skin lesions. Conclusion Near‐infrared light may have use in an outpatient setting for skin cancer delineation, possibly reducing the rate of positive margins.

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Recent use of medical infrared thermography in skin neoplasms

Abstract: Trends and future challenges have been established to improve the application of IRT in this field, disclosing that dynamic thermography is a promising tool for early identification of oncological skin conditions.

Cited by 39 publications

References 28 publications

Numerical modelling of skin tumour tissue with temperature-dependent properties for dynamic thermography

Numerical modelling of skin tumour tissue with temperature-dependent properties for dynamic thermography

Evaluation of the temperature of posterior lower limbs skin during the whole body vibration measured by infrared thermography: Cross-sectional study analysis using linear mixed effect model

Near‐infrared heating of skin to delineate non‐melanoma skin cancer lesions: A pilot study

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