Recently Developed New, Sensitive, Time-Effective and Cost-Effective Diagnostic Tests of Malaria

Kumar, Sushil; Kumari, Renu

doi:10.16943/ptinsa/2015/v81i2/48100

Cited by 4 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On exposing intact blood cells to a powerful magnetic field, the paramagnetic Fe 3+ ions in hemozoin distract the synchronizing hydrogen atoms. The more the hemozoin crystals inside the RBC’s, the more rapidly the hydrogen atoms are disrupted reflecting the ‘parasite load’ in blood ( Kumar & Renu, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

Malaria: biochemical, physiological, diagnostic, and therapeutic updates

El Saftawy,

Farag,

Gebreil

et al. 2024

PeerJ

View full text Add to dashboard Cite

Background Malaria has been appraised as a significant vector-borne parasitic disease with grave morbidity and high-rate mortality. Several challenges have been confronting the efficient diagnosis and treatment of malaria. Method Google Scholar, PubMed, Web of Science, and the Egyptian Knowledge Bank (EKB) were all used to gather articles. Results Diverse biochemical and physiological indices can mirror complicated malaria e.g., hypoglycemia, dyslipidemia, elevated renal and hepatic functions in addition to the lower antioxidant capacity that does not only destroy the parasite but also induces endothelial damage. Multiple trials have been conducted to improve recent points of care in malaria involving biosensors, lap on-chip, and microdevices technology. Regarding recent therapeutic trials, chemical falcipain inhibitors and plant extracts with anti-plasmodial activities are presented. Moreover, antimalaria nano-medicine and the emergence of nanocarrier (either active or passive) in drug transportation are promising. The combination therapeutic trials e.g., amodiaquine + artemether + lumefantrine are presented to safely counterbalance the emerging drug resistance in addition to the Tafenoquine as a new anti-relapse therapy. Conclusion Recognizing the pathophysiology indices potentiate diagnosis of malaria. The new points of care can smartly manipulate the biochemical and hematological alterations for a more sensitive and specific diagnosis of malaria. Nano-medicine appeared promising. Chemical and plant extracts remain points of research.

show abstract

Section: Resultsmentioning

confidence: 99%

Malaria: biochemical, physiological, diagnostic, and therapeutic updates

El Saftawy,

Farag,

Gebreil

et al. 2024

PeerJ

View full text Add to dashboard Cite

show abstract

“…Serology does not detect current infection but rather measures past exposure [6]. Newly developed rolling circle-enhanced enzyme activity detection (REEAD) and micromagnetic resonance reflaxometric (MMR) test are amenable to deployment in field conditions and are highly accurate and cost-and time-effective [92].…”

Section: Diagnosis Of Malariamentioning

confidence: 99%

Old and Recent Advances in Life Cycle, Pathogenesis, Diagnosis, Prevention, and Treatment of Malaria Including Perspectives in Ethiopia

Nureye

Assefa

2020

The Scientific World Journal

View full text Add to dashboard Cite

Malaria, caused by apicomplexan parasite, is an old disease and continues to be a major public health threat in many countries. This article aims to present different aspects of malaria including causes, pathogenesis, prevention, and treatment in an articulate and comprehensive manner. Six Plasmodium species are recognized as the etiology of human malaria, of which Plasmodium falciparum is popular in East and Southern Africa. Malaria is transmitted mainly through Anopheles gambiae and Anopheles funestus, the two most effective malaria vectors in the world. Half of the world’s population is at risk for malaria infection. Globally, the morbidity and mortality rates of malaria have become decreased even though few reports in Ethiopia showed high prevalence of malaria. The malaria parasite has a complex life cycle that takes place both inside the mosquito and human beings. Generally, diagnosis of malaria is classified into clinical and parasitological diagnoses. Lack of clear understanding on the overall biology of Plasmodium has created a challenge in an effort to develop new drugs, vaccines, and preventive methods against malaria. However, three types of vaccines and a lot of novel compounds are under perclinical and clinical studies that are triggered by the occurrence of resistance among commonly used drugs and insecticides. Antiadhesion adjunctive therapies are also under investigation in the laboratory. In addition to previously known targets for diagnostic tool, vaccine and drug discovery scientists from all corner of the world are in search of new targets and chemical entities.

show abstract

“…The current diagnostic methods used for identification of Plasmodium species from blood samples are light/ fluorescence microscopy (gold standard method), immuno-chromatographic lateral flow assays (RDTs-rapid diagnostic tests), serology tests, and nucleic acid amplification techniques including PCR (polymerase chain reaction) and isothermal amplification [25]. Rolling circle enhanced enzyme activity detection (REEAD) and micromagnetic resonance reflaxometric (MMR) tests are recently developed parasitological methods appropraite for utilization in field detection of malaria infected individuals for population screenings [26].…”

Section: Introductionmentioning

confidence: 99%

Malaria: Introductory Concepts, Resistance Issues and Current Medicines

Nureye¹

2021

Plasmodium Species and Drug Resistance

View full text Add to dashboard Cite

Malaria continues to be the main community health problem in numerous nations. Six species of Plasmodium are documented as the cause of human malaria infection. Among others, Plasmodium falciparum and Plasmodium vivax parasites produce an immense challenge in the public health. Anopheles funestus and Anopheles gambiae are the major transimmiter of the disease (malaria) from one person to another. The disease parasite has a complicated cycle of life that occurs in human and mosquitoes. In general, malaria diagnosis is divided into parasitological and clinical diagnosis. Internationally, the death rate of malaria becomes reduced although few records from Ethiopia describe the presence of raised prevalence of malaria in certain areas. Apart from reduction in incidence and prevalence, transmission of malaria is continued throughout the globe. Hence, its control needs a combined approach comprising treatment with effective antimalarial agents. A lot of novel compounds are under pre-clinical and clinical studies that are triggered by the occurrence of resistance among commonly used antimalarial drugs. In addition to the already known new compounds and targets for drug discovery, scientists from all corner of the world are in search of novel targets and chemical entities.

show abstract

Recently Developed New, Sensitive, Time-Effective and Cost-Effective Diagnostic Tests of Malaria

Cited by 4 publications

References 9 publications

Malaria: biochemical, physiological, diagnostic, and therapeutic updates

Malaria: biochemical, physiological, diagnostic, and therapeutic updates

Old and Recent Advances in Life Cycle, Pathogenesis, Diagnosis, Prevention, and Treatment of Malaria Including Perspectives in Ethiopia

Malaria: Introductory Concepts, Resistance Issues and Current Medicines

Contact Info

Product

Resources

About