Recepteur d'origine nantais contributes to the development of endometriosis via promoting epithelial‐mesenchymal transition of a endometrial epithelial cells

Qin, Yu; Wang, Jianzhang; Li, Tiantian; Guo, Xinyue; Ding, Shaojie; Che, Xuan; Zhu, Libo; Peng, Yangying; Xu, Xinxin; Zou, Gen; Zhang, Xinmei

doi:10.1111/jcmm.16261

Cited by 8 publications

(4 citation statements)

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“…Common transcription factors include ZEB family, Snail family, or Twist family [ 34 , 35 ]. In HEC-1B cells, we found that the transcription factor affected by RON was ZEB2, which was consistent with previous results obtained using MSP to stimulate endometrial epithelial cells with MSP (the agonist of RON) [ 36 ]. Increased expression of ZEB2 resulted in decreased expression of E-cadherin.…”

Section: Discussionsupporting

confidence: 92%

RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma

Qin

Wang

et al. 2021

BioMed Research International

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Endometrial adenocarcinoma is one of the most prevalent female reproductive tract cancers in the world, and the development of effective treatment is still the main goal of its current research. Epithelial-mesenchymal transition (EMT) plays a significant part in the occurrence and development of epithelial carcinoma, including endometrial adenocarcinoma. Recepteur d’origine nantais (RON) induces EMT and promotes proliferation, migration, and invasion in various epithelial-derived cancers, but its role in endometrial adenocarcinoma is still poorly studied. The purpose of this study is to verify the overexpression of RON in endometrial adenocarcinoma and to explore its specific roles. RON expression in tumor lesions was verified by immunohistochemical staining, HEC-1B cells were used to construct stable cell lines with RON overexpression or knockdown to investigate the effects of RON on the function of endometrial adenocarcinoma cells, and xenotransplantation experiment was carried out in nude mice to explore the effect of RON on the growth of endometrial adenocarcinoma in vivo. This study revealed that RON could promote the proliferation, migration, and invasion of HEC-1B cells and induce EMT, and these effects were regulated through the Smad pathway. RON overexpression could promote growth of endometrial adenocarcinoma cells in nude mice, while its inhibitor BMS777607 could restrict this role. RON played an important role in endometrial adenocarcinoma and had a potential to become a new therapeutic target for endometrial adenocarcinoma.

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Section: Discussionsupporting

confidence: 92%

RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma

Qin

Wang

et al. 2021

BioMed Research International

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“…Chen et al revealed a significant decrease in E-cadherin expression and a significant increase in C-X-C motif chemokine 12 in the endometrial tissue of EM patients (Chen et al, 2020). Another finding presented by Yu et al (2021) showed strong staining of N-cadherin and E-cadherin in endometriotic lesions and control endometria, respectively. These observations show that EMT participates in the development of EM, and is a workable indicator in tracing the aetiology of the disease.…”

Section: Discussionmentioning

confidence: 88%

Endometriosis: Pathogenesis, Diagnosis and Treatment, volume II

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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“…Chen et al revealed a significant decrease in E-cadherin expression and a significant increase in C-X-C motif chemokine 12 in the endometrial tissue of EM patients ( Chen et al, 2020 ). Another finding presented by Yu et al (2021) showed strong staining of N-cadherin and E-cadherin in endometriotic lesions and control endometria, respectively. These observations show that EMT participates in the development of EM, and is a workable indicator in tracing the aetiology of the disease.…”

Section: Introductionmentioning

confidence: 88%

Oestrogen-induced epithelial-mesenchymal transition (EMT) in endometriosis: Aetiology of vaginal agenesis in Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome

et al. 2022

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Endometriosis occurs when endometrial-like tissue forms and grows outside the uterus due to oestrogen-induced epithelial-mesenchymal transition in the female reproductive tract. Factors that suppress this event could become potential therapeutic agents against disease occurrence and progression. However, an overview of these studies is still lacking. This review assessed the impact of a number factors on oestrogen-mediated epithelial-mesenchymal transition in the emergence of several diseases in the female reproductive tract, primarily endometriosis. The association between epithelial-mesenchymal transition and Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome was also investigated. Oestrogen, Wnt4 and epithelial-mesenchymal transition were chosen as keywords in Scopus, PubMed, and Web of Science searches performed on 28th June 2021. Study selection was refined to cancer-irrelevant, English, original articles published between years 2011–2021. The full-text assessment was carried out for topic-related articles after title and abstract screening. Included studies were summarised and assessed for their risk of bias using the Office of Health Assessment and Translation tool. In this review, 10 articles investigating oestrogen and epithelial-mesenchymal transition in the female reproductive tract were summarised and classified into two groups: seven studies under ‘factor’-modulated epithelial-mesenchymal transition and three studies under ‘factor’-manipulated oestrogen-induced epithelial-mesenchymal transition. The current evidence proposes that epithelial-mesenchymal transition is one of the prime causes of reproductive-related disease. This event could be mediated by distinct stimuli, specifically oestrogen and Wnt4 aberration. The results of this review suggest that oestrogen and Wnt4 participate in epithelial-mesenchymal transition in vaginal epithelial cells in MRKH syndrome, adopting from the theories of endometriosis development, which could therefore serve as a foundation for novel target treatment, specifically related to vaginal epithelialisation, to ensure better surgical outcomes.

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Recepteur d'origine nantais contributes to the development of endometriosis via promoting epithelial‐mesenchymal transition of a endometrial epithelial cells

Cited by 8 publications

References 54 publications

RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma

RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma

Endometriosis: Pathogenesis, Diagnosis and Treatment, volume II

Oestrogen-induced epithelial-mesenchymal transition (EMT) in endometriosis: Aetiology of vaginal agenesis in Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome

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