The term "schizophrenia" has been associated with stigma since its appearance in 1911. Several destigmatization programs in occidental countries have had favorable results. In Japan, schizophrenia has been renamed as a kind of integration disorder. A debate is ongoing about whether to replace the term schizophrenia with "salience syndrome", a term that implies a disorder of stimulus-reaction control. Increased dopamine, a mediator between a stimulus and the affective reaction, is the supposed neurobiological correlate. Reducing the disease entity schizophrenia to a syndromal level might mean that accessory symptoms, which could be important for predicting the course and outcome of the illness, are neglected. A mere syndromal description with a new term will not improve destigmatization. It will, however, blur physicians' perception and impair patients' acceptance of the disorder. Furthermore, ethnic and cultural aspects are not reflected by nosological changes.bs_bs_banner Offi cial journal of the Pacifi c Rim College of Psychiatrists